Microorganisms,
Год журнала:
2021,
Номер
9(5), С. 957 - 957
Опубликована: Апрель 29, 2021
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
the
most
common
chronic
disease.
Its
worldwide
prevalence
rapidly
increasing
and
currently
estimated
at
24%.
NAFLD
highly
associated
with
many
features
of
metabolic
syndrome,
including
obesity,
insulin
resistance,
hyperlipidaemia,
hypertension.
The
pathogenesis
complex
not
fully
understood,
but
there
evidence
that
gut
microbiota
strongly
implicated
in
development
NAFLD.
In
this
review,
we
discuss
major
factors
induce
dysbiosis
disrupt
intestinal
permeability,
as
well
possible
mechanisms
leading
to
We
also
consistent
NAFLD-associated
signatures
immunological
involved
maintaining
barrier
tolerance
gut-derived
factors.
Gut-derived
factors,
microbial,
dietary,
host-derived
pathogenesis,
are
discussed
detail.
Finally,
review
available
diagnostic
prognostic
methods,
summarise
latest
knowledge
on
promising
microbiota-based
biomarkers,
therapeutic
strategies
manipulate
microbiota,
faecal
transplantation,
probiotics
prebiotics,
deletions
individual
strains
bacteriophages,
blocking
production
harmful
metabolites.
Frontiers in Nutrition,
Год журнала:
2021,
Номер
8
Опубликована: Авг. 26, 2021
An
increased
intestinal
permeability
has
been
described
in
various
gastrointestinal
and
non-gastrointestinal
disorders.
Nevertheless,
the
concept
definition
of
is
relatively
broad
includes
not
only
an
altered
paracellular
route,
regulated
by
tight
junction
proteins,
but
also
transcellular
route
involving
membrane
transporters
channels,
endocytic
mechanisms.
Paracellular
can
be
assessed
vivo
using
different
molecules
(e.g.,
sugars,
polyethylene
glycols,
51
Cr-EDTA)
ex
Ussing
chambers
combining
electrophysiology
probes
molecular
sizes.
The
latter
still
gold
standard
technique
for
assessing
epithelial
barrier
function,
whereas
techniques,
including
putative
blood
biomarkers
such
as
fatty
acid-binding
protein
zonulin,
are
broadly
used
despite
limitations.
In
second
part
review,
current
evidence
role
impaired
function
pathophysiology
selected
liver
diseases
discussed.
Celiac
disease
one
conditions
with
best
playing
a
crucial
zonulin
its
proposed
regulator.
Increased
clearly
present
inflammatory
bowel
disease,
question
whether
this
primary
event
or
consequence
inflammation
remains
unsolved.
gut-liver
axis
increasingly
recognized
chronic
alcoholic
metabolic
disease.
Finally,
does
support
important
bile
acid
diarrhea.
Nutrients,
Год журнала:
2021,
Номер
13(5), С. 1442 - 1442
Опубликована: Апрель 24, 2021
NAFLD
is
the
world's
most
common
chronic
liver
disease,
and
its
increasing
prevalence
parallels
global
rise
in
diabetes
obesity.
It
characterised
by
fat
accumulation
evolving
to
non-alcoholic
steatohepatitis
(NASH),
an
inflammatory
subtype
that
can
lead
fibrosis
cirrhosis.
Currently,
there
no
effective
pharmacotherapeutic
treatment
for
NAFLD.
Treatment
therefore
based
on
lifestyle
modifications
including
changes
diet
exercise,
although
it
unclear
what
form
of
intervention
is.
The
aim
this
review,
then,
discuss
role
specific
nutrients
effects
different
dietary
interventions
well
established
unhealthy
rich
calories,
sugars,
saturated
fats
low
polyunsaturated
fatty
acids,
fibre,
micronutrients
plays
a
critical
development
progression
disease.
However,
few
clinical
trials
have
evaluated
nutrition
We,
therefore,
summarise
currently
known
about
macronutrients,
foods,
patterns
prevention
treatment.
Most
current
guidelines
recommend
low-calorie,
plant-based
diets,
such
as
Mediterranean
diet,
pattern
treat
More
are
required,
however,
identify
best
evidence-based
approach.
Microorganisms,
Год журнала:
2021,
Номер
9(5), С. 957 - 957
Опубликована: Апрель 29, 2021
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
the
most
common
chronic
disease.
Its
worldwide
prevalence
rapidly
increasing
and
currently
estimated
at
24%.
NAFLD
highly
associated
with
many
features
of
metabolic
syndrome,
including
obesity,
insulin
resistance,
hyperlipidaemia,
hypertension.
The
pathogenesis
complex
not
fully
understood,
but
there
evidence
that
gut
microbiota
strongly
implicated
in
development
NAFLD.
In
this
review,
we
discuss
major
factors
induce
dysbiosis
disrupt
intestinal
permeability,
as
well
possible
mechanisms
leading
to
We
also
consistent
NAFLD-associated
signatures
immunological
involved
maintaining
barrier
tolerance
gut-derived
factors.
Gut-derived
factors,
microbial,
dietary,
host-derived
pathogenesis,
are
discussed
detail.
Finally,
review
available
diagnostic
prognostic
methods,
summarise
latest
knowledge
on
promising
microbiota-based
biomarkers,
therapeutic
strategies
manipulate
microbiota,
faecal
transplantation,
probiotics
prebiotics,
deletions
individual
strains
bacteriophages,
blocking
production
harmful
metabolites.
