Beta-blockers in the era of precision medicine in patients with cirrhosis

Journal of Hepatology, Год журнала: 2022, Номер 78(4), С. 866 - 872

Опубликована: Дек. 15, 2022

Язык: Английский

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Liver cirrhosis and immune dysfunction

International Immunology, Год журнала: 2022, Номер 34(9), С. 455 - 466

Опубликована: Июль 6, 2022

Abstract Cirrhosis is end-stage liver disease resulting from various etiologies and a common cause of death worldwide. The progression compensated to decompensated cirrhosis acute-on-chronic failure (ACLF) due multiple factors, including continuation alcohol use or continued exposure other toxins, an imbalance the gut microbiota (dysbiosis), increased permeability disrupted immune response. This response also named cirrhosis-associated dysfunction, which characterized by worsening systemic inflammation with concomitant paralysis, as deteriorates. review highlights central immunologic events during exacerbation characterizes different cell populations involved therein.

Язык: Английский

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The gut–liver axis in immune remodeling of hepatic cirrhosis

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Авг. 8, 2022

In healthy settings, the gut–liver axis allows host–microbiota communications and mediates immune homeostasis through bidirectional regulation. Meanwhile, in diseases, gut dysbiosis, combined with an impaired intestinal barrier, introduces pathogens their toxic metabolites into system, causing massive alternations liver other extrahepatic organs. Accumulating evidence suggests that these changes are associated progression of many especially hepatic cirrhosis. Pathogen-associated molecular patterns originated from microbes directly stimulate hepatocytes cells different pattern recognition receptors, a process further facilitated by damage-associated released injured hepatocytes. Hepatic stellate cells, along contribute to this proinflammatory profibrogenic transformation. Moreover, cirrhosis-associated dysfunction, imbalanced status characterized systemic inflammation deficiency, is linked dysbiosis. Though hypothesis starts link dysbiosis decompensated cirrhosis clinical perspective, clearer demonstration still needed for role gut–liver–immune progression. This review discusses states both cirrhotic settings and, more importantly, summarizes current about how microbiota-derived remodeling contributes via axis.

Язык: Английский

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Role of inflammasomes and cytokines in immune dysfunction of liver cirrhosis

Cytokine, Год журнала: 2023, Номер 170, С. 156347 - 156347

Опубликована: Авг. 26, 2023

Язык: Английский

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Intensive care management of acute-on-chronic liver failure

Intensive Care Medicine, Год журнала: 2023, Номер 49(8), С. 903 - 921

Опубликована: Авг. 1, 2023

Язык: Английский

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