The Journal of Experimental Medicine,
Год журнала:
2022,
Номер
219(6)
Опубликована: Май 6, 2022
Neutrophils
are
the
first
responders
to
infection
and
inflammation
thus
a
critical
component
of
innate
immune
defense.
Understanding
behavior
neutrophils
as
they
act
within
various
inflammatory
contexts
has
provided
insights
into
their
role
in
sterile
infectious
diseases;
however,
field
cancer
is
comparatively
young.
Here,
we
summarize
key
concepts
current
knowledge
gaps
related
diverse
roles
throughout
progression.
We
discuss
sources
neutrophil
heterogeneity
provide
recommendations
on
nomenclature
for
states
that
distinct
maturation
activation.
address
discrepancies
literature
highlight
need
technical
standards
ought
be
considered
between
laboratories.
Finally,
review
emerging
questions
biology
immunity
cancer.
Overall,
emphasize
more
population
than
previously
appreciated
may
present
novel
unexplored
opportunities
treat
Nature reviews. Immunology,
Год журнала:
2020,
Номер
20(10), С. 615 - 632
Опубликована: Сен. 4, 2020
The
coronavirus
disease
2019
(COVID-19)
pandemic
caused
by
severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
is
the
most
formidable
challenge
to
humanity
in
a
century.
It
widely
believed
that
prepandemic
normalcy
will
never
return
until
safe
and
effective
vaccine
strategy
becomes
available
global
vaccination
programme
implemented
successfully.
Here,
we
discuss
immunological
principles
need
be
taken
into
consideration
development
of
COVID-19
strategies.
On
basis
these
principles,
examine
current
candidates,
their
strengths
potential
shortfalls,
make
inferences
about
chances
success.
Finally,
scientific
practical
challenges
faced
process
developing
successful
ways
which
strategies
may
evolve
over
next
few
years.
This
Review
outlines
guiding
for
design
analyses
landscape
ahead.
Archives of Disease in Childhood,
Год журнала:
2020,
Номер
106(5), С. 429 - 439
Опубликована: Дек. 1, 2020
In
contrast
to
other
respiratory
viruses,
children
have
less
severe
symptoms
when
infected
with
the
novel
acute
syndrome
coronavirus
2
(SARS-CoV-2).
this
review,
we
discuss
proposed
hypotheses
for
age-related
difference
in
severity
of
disease
2019
(COVID-19).
Factors
explain
COVID-19
and
adults
include
those
that
put
at
higher
risk
protect
children.
The
former
include:
(1)
increase
endothelial
damage
changes
clotting
function;
(2)
density,
increased
affinity
different
distribution
angiotensin
converting
enzyme
receptors
transmembrane
serine
protease
2;
(3)
pre-existing
antibodies
(including
antibody-dependent
enhancement)
T
cells;
(4)
immunosenescence
inflammaging,
including
effects
chronic
cytomegalovirus
infection;
(5)
a
prevalence
comorbidities
associated
(6)
lower
levels
vitamin
D.
might
differences
innate
adaptive
immunity;
more
frequent
recurrent
concurrent
infections;
immunity
coronaviruses;
microbiota;
melatonin;
protective
off-target
live
vaccines
(7)
intensity
exposure
SARS-CoV-2.
Cell,
Год журнала:
2020,
Номер
183(3), С. 771 - 785.e12
Опубликована: Окт. 1, 2020
Trained
innate
immunity,
induced
via
modulation
of
mature
myeloid
cells
or
their
bone
marrow
progenitors,
mediates
sustained
increased
responsiveness
to
secondary
challenges.
Here,
we
investigated
whether
anti-tumor
immunity
can
be
enhanced
through
induction
trained
immunity.
Pre-treatment
mice
with
β-glucan,
a
fungal-derived
prototypical
agonist
resulted
in
diminished
tumor
growth.
The
effect
β-glucan-induced
was
associated
transcriptomic
and
epigenetic
rewiring
granulopoiesis
neutrophil
reprogramming
toward
an
phenotype;
this
process
required
type
I
interferon
signaling
irrespective
adaptive
the
host.
Adoptive
transfer
neutrophils
from
β-glucan-trained
naive
recipients
suppressed
growth
latter
ROS-dependent
manner.
Moreover,
transmissible
by
transplantation
recipient
mice.
Our
findings
identify
novel
therapeutically
relevant
facet
involving
appropriate
granulopoiesis.
