Neuron, Год журнала: 2023, Номер 111(17), С. 2709 - 2726.e9
Опубликована: Июнь 21, 2023
Язык: Английский
The Lancet, Год журнала: 2024, Номер 404(10452), С. 572 - 628
Опубликована: Июль 31, 2024
Язык: Английский
Процитировано
559
Neuron, Год журнала: 2022, Номер 110(21), С. 3484 - 3496
Опубликована: Окт. 7, 2022
Persistent neurological and neuropsychiatric symptoms affect a substantial fraction of people after COVID-19 represent major component the post-acute syndrome, also known as long COVID. Here, we review what is understood about pathobiology impact on CNS discuss possible neurobiological underpinnings cognitive affecting survivors. We propose chief mechanisms that may contribute to this emerging health crisis.
Язык: Английский
Процитировано
292
Cell, Год журнала: 2022, Номер 186(1), С. 194 - 208.e18
Опубликована: Дек. 28, 2022
The diversity and complex organization of cells in the brain have hindered systematic characterization age-related changes its cellular molecular architecture, limiting our ability to understand mechanisms underlying functional decline during aging. Here, we generated a high-resolution cell atlas aging within frontal cortex striatum using spatially resolved single-cell transcriptomics quantified gene expression spatial major types these regions over mouse lifespan. We observed substantially more pronounced state, expression, non-neuronal neurons. Our data revealed signatures glial immune activation aging, particularly enriched subcortical white matter, identified both similarities notable differences cell-activation patterns induced by systemic inflammatory challenge. These results provide critical insights into inflammation brain.
Язык: Английский
Процитировано
239
Cell, Год журнала: 2022, Номер 185(5), С. 831 - 846.e14
Опубликована: Фев. 16, 2022
Язык: Английский
Процитировано
211
Genome Medicine, Год журнала: 2023, Номер 15(1)
Опубликована: Янв. 26, 2023
Abstract Alzheimer’s disease (AD) is a genetically complex and heterogeneous disorder with multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary tangles, neuroinflammation. Over the past decade, emerging evidence has implicated both beneficial pathological roles for innate immune genes cells, peripheral cells such as T which can infiltrate brain either ameliorate or exacerbate AD neuropathogenesis. These findings support neuroimmune axis of AD, in interplay adaptive systems inside outside critically impacts etiology pathogenesis AD. In this review, we discuss complexities neuropathology at levels genetics cellular physiology, highlighting signaling pathways associated risk interactions among brain. We emphasize role mechanisms by monocytes, influence neuropathology, microglial clearance amyloid-β peptide, key component plaque cores, pro-inflammatory cytotoxic activity microglia, astrogliosis, their vasculature. Finally, review challenges outlook establishing immune-based therapies treating preventing
Язык: Английский
Процитировано
170
Nature, Год журнала: 2023, Номер 618(7965), С. 467 - 479
Опубликована: Июнь 14, 2023
Язык: Английский
Процитировано
127
International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(14), С. 7491 - 7491
Опубликована: Июль 13, 2021
The glymphatic system is a fluid-transport that accesses all regions of the brain. It facilitates exchange cerebrospinal fluid and interstitial clears waste from metabolically active Astrocytic endfeet their dense expression aquaporin-4 water channels promote between perivascular spaces neuropil. Cerebrospinal fluids are together transported back to vascular compartment by meningeal cervical lymphatic vessels. Multiple lines work show neurological diseases in general impair transport. Insofar as plays pseudo-lymphatic role central nervous system, it poised play neuroinflammation. In this review, we discuss how association with vessel calls for renewal established concepts on CNS an immune-privileged site. We also potential approaches target combat
Язык: Английский
Процитировано
123
Nature, Год журнала: 2022, Номер 612(7940), С. 417 - 429
Опубликована: Дек. 14, 2022
Язык: Английский
Процитировано
121
ACS Biomaterials Science & Engineering, Год журнала: 2022, Номер 8(6), С. 2321 - 2335
Опубликована: Май 31, 2022
Large-sized bone defects are a great challenge in clinics and considerably impair the quality of patients' daily life. Tissue engineering strategies using cells, scaffolds, bioactive molecules to regulate microenvironment regeneration is promising approach. Zinc, magnesium, iron ions natural elements tissue participate many physiological processes metabolism therefore have potential for regeneration. In this review, we performed systematic analysis on effects zinc, engineering. We focus role these properties scaffolds (mechanical strength, degradation, osteogenesis, antibacterial properties, etc.). hope that our summary current research achievements notifications improve repair will find new inspiration breakthroughs inspire future research.
Язык: Английский
Процитировано
95
Annual Review of Neuroscience, Год журнала: 2022, Номер 45(1), С. 425 - 445
Опубликована: Апрель 18, 2022
Mounting evidence indicates that microglia, which are the resident immune cells of brain, play critical roles in a diverse array neurodevelopmental processes required for proper brain maturation and function. This has ultimately led to growing speculation microglial dysfunction may role disorder (NDD) pathoetiology. In this review, we first provide an overview how microglia mechanistically contribute sculpting developing neuronal circuits. To example disruption biology impacts NDD development, also highlight emerging linked dysregulation autism spectrum pathogenesis. recent years, there been increasing interest gut microbiome shapes biology. last section put spotlight on burgeoning area research discuss microbiota-dependent modulation is currently thought influence progression.
Язык: Английский
Процитировано
88