Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Июнь 29, 2023
At
the
turn
of
century,
researchers
discovered
a
unique
subtype
T
helper
cells
that
secretes
IL-17
and
defined
it
as
Th17.
The
latest
study
found
Th17
play
both
positive
negative
definitive
roles
in
regulation
antitumor
immune
responses.
Although
function
tumor
microenvironment
remains
poorly
understood,
more
studies
have
shown
this
paradoxical
dual
role
is
closely
related
to
plasticity
recent
decades.
Further
understanding
characteristics
could
yield
novel
useful
therapeutic
approaches
treat
cancer.
In
review,
we
further
present
high
Th17-producing
immunity.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Фев. 2, 2023
Abstract
Tumor-specific
T
cells
are
frequently
exhausted
by
chronic
antigenic
stimulation.
We
here
report
on
a
human
antigen-specific
ex
vivo
model
to
explore
new
therapeutic
options
for
cell
immunotherapies.
generated
with
this
resemble
tumor-infiltrating
phenotypic
and
transcriptional
level.
Using
targeted
pooled
CRISPR-Cas9
screen
individual
gene
knockout
validation
experiments,
we
uncover
sorting
nexin-9
(SNX9)
as
mediator
of
exhaustion.
Upon
TCR/CD28
stimulation,
deletion
SNX9
in
CD8
decreases
PLCγ1,
Ca
2+
,
NFATc2-mediated
signaling
reduces
expression
NR4A1/3
TOX.
enhances
memory
differentiation
IFNγ
secretion
adoptively
transferred
results
improved
anti-tumor
efficacy
chimeric
antigen
receptor
vivo.
Our
findings
highlight
that
targeting
is
strategy
prevent
exhaustion
enhance
immunity.
Viruses,
Год журнала:
2024,
Номер
16(2), С. 219 - 219
Опубликована: Янв. 31, 2024
Chronic
Human
Immunodeficiency
Virus
(HIV)
infection
remains
a
significant
challenge
to
global
public
health.
Despite
advances
in
antiretroviral
therapy
(ART),
which
has
transformed
HIV
from
fatal
disease
into
manageable
chronic
condition,
definitive
cure
elusive.
One
of
the
key
features
is
immune
activation
and
inflammation,
are
strongly
associated
with,
predictive
of,
progression,
even
patients
successfully
treated
with
suppressive
ART.
inflammation
characterized
by
persistent
cell
metabolic
dysregulation,
cellular
exhaustion
dysfunction.
This
review
aims
summarize
current
knowledge
interplay
between
metabolism,
T
dysfunction
infection,
also
discusses
use
humanized
mice
models
study
pathogenesis
develop
novel
therapeutic
strategies.
Cancers,
Год журнала:
2025,
Номер
17(1), С. 154 - 154
Опубликована: Янв. 6, 2025
Inflammation
plays
a
crucial
role
in
wound
healing
and
the
host
immune
response
following
pathogenic
invasion.
However,
unresolved
chronic
inflammation
can
result
tissue
fibrosis
genetic
alterations
that
contribute
to
pathogenesis
of
human
diseases
such
as
cancer.
Recent
scientific
advancements
exploring
underlying
mechanisms
malignant
cellular
transformations
cancer
progression
have
exposed
significant
disparities
between
pediatric
adult-onset
cancers.
For
instance,
cancers
tend
lower
mutational
burdens
arise
actively
developing
tissues,
where
cell-cycle
dysregulation
leads
gene,
chromosomal,
fusion
gene
development
not
seen
counterparts.
As
such,
findings
adult
cannot
be
directly
applied
cancers,
unique
mutations
inherent
etiologies
remain
poorly
understood.
Here,
we
review
processes
chromosomal
instability,
tumor
microenvironment,
tumorigenesis
transformation
explore
current
therapeutic
interventions
maintain
and/or
restore
inflammatory
homeostasis.
Biomaterials,
Год журнала:
2022,
Номер
289, С. 121757 - 121757
Опубликована: Авг. 24, 2022
The
alternations
in
the
hypoxic
and
immune
microenvironment
are
closely
related
to
therapeutic
effect
prognosis
of
oral
squamous
cell
carcinoma
(OSCC).
Herein,
a
new
nanocomposite,
TiO2@[email
protected]
is
constructed
from
ruthenium-based
photosensitizer
(Ru)
modified-TiO2
nanoparticles
(NPs)
loaded
with
siRNA
hypoxia-inducible
factor-1α
(HIF-1α).
Under
visible
light
irradiation,
can
elicit
both
Type
I
II
photodynamic
effects,
which
causes
lysosomal
damage,
HIF-1α
gene
silencing,
OSCC
elimination
efficiently.
As
consequence
hypoxia
relief
pyroptosis
induction,
reshapes
by
downregulation
key
immunosuppressive
factors,
upregulation
cytokines,
activation
CD4+
CD8+
T
lymphocytes.
Furthermore,
patient-derived
xenograft
(PDX)
rat
experimental
carcinogenesis
models
prove
that
protected]-mediated
therapy
significantly
inhibits
tumor
growth
progression,
markedly
enhances
cancer
immunity.
In
all,
this
study
presents
an
effective
hypoxia-adaptive
photo-immunotherapeutic
nanosystem
great
potential
for
prevention
treatment.
