Pflügers Archiv - European Journal of Physiology, Год журнала: 2024, Номер unknown
Опубликована: Сен. 11, 2024
Язык: Английский
Cell, Год журнала: 2024, Номер 187(19), С. 5171 - 5194
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
16
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Июль 16, 2024
While most of the cancer immunotherapy strategies engage adaptive immunity, especially tumor-associated T cells, small fraction responding patients and types cancers amenable, possibility severe adverse effects limit its usage. More effective general interventions are urgently needed. Recently, a de facto innate immune memory, termed ‘trained immunity’, has become new research focal point, promises to be powerful tool for achieving long-term therapeutic benefits against cancers. Trained immunity-inducing agents such as BCG fungal glucan have been shown able avert suppressive tumor microenvironment (TME), enhance cell responses, eventually lead regression. Here, we review current understating trained immunity induction highlight critical roles emergency granulopoiesis, interferon γ tissue-specific induction. Preclinical clinical studies that exploited inducers summarized, repurposed from other fields proposed. We also outline challenges opportunities in future immunotherapies. envisage more vaccines will combine with therapies.
Язык: Английский
Процитировано
8
Clinical Microbiology Reviews, Год журнала: 2024, Номер 37(4)
Опубликована: Окт. 3, 2024
SUMMARYIn the United Kingdom (UK) in 2022/23, influenza virus infections returned to levels recorded before COVID-19 pandemic, exerting a substantial burden on an already stretched National Health Service (NHS) through increased primary and emergency care visits subsequent hospitalizations. Population groups ≤4 years ≥65 of age, those with underlying health conditions, are at greatest risk influenza-related hospitalization. Recent advances vaccine technologies may help mitigate this burden. This review aims summarize landscape by describing different that currently use UK more widely. The also describes under development, including mRNA, universal vaccines which aim provide broader or protection. is exciting important era for vaccinations, critical protect against disease still exerts across all populations disproportionately impacts most vulnerable, despite it being over 80 since first were deployed.
Язык: Английский
Процитировано
0
Journal of Applied Veterinary Science And Technology, Год журнала: 2024, Номер 5(1), С. 66 - 71
Опубликована: Апрель 30, 2024
Background: Epigallocatechin gallate is the primary polyphenol constituent of green tea. It has ability to inhibit pathological processes caused by oxidants. However, in certain cases, tea diet known exert pro-oxidant effects. In addition, studies have shown that epigallocatechin negatively affects cells. Several on showed increased oxidative stress and decreased intracellular antioxidants. Furthermore, it can stimulate an inflammatory response from innate immune system, which may contribute elimination effects gallate. Purpose: This study aims investigate responses (IL-1, IL-6, TNF-α) mice kidneys due Methods: involved use experimental animals aged between two three months with average body weight 20 grams. The were randomly divided into groups, namely control group treatment group, each consisting 16 samples. dose used this was 750 mg/kg bw. administered for days, after collected. Immunohistochemical staining observe response, including IL-1, IL-6 TNF-α. Subsequently, all data collected statistically analyzed using independent t-test. Results: results analysis a significant difference expression (p = 0.018) TNF-α 0.000), but no IL-1 0.106). Conclusion: conclusion, found induce kidneys.
Язык: Английский
Процитировано
0
Pflügers Archiv - European Journal of Physiology, Год журнала: 2024, Номер unknown
Опубликована: Сен. 11, 2024
Язык: Английский
Процитировано
0