Immune Memory: A New Frontier in Treating Recurrent Inflammatory Skin Diseases

Clinical Reviews in Allergy & Immunology, Год журнала: 2025, Номер 68(1)

Опубликована: Март 18, 2025

Язык: Английский

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Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections

Trends in Immunology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

The devastating impact of respiratory infections demonstrates the critical need for novel prophylactic vaccines. In this opinion article, we advocate bacterial immunotherapies as a complementary tool in our fight against infections. These can activate wide spectrum immunological mechanisms, with trained immunity (TI) being particularly significant. This phenomenon has led to concept immunity-based vaccines (TIbVs), which represent approach vaccinology. We discuss examples TIbVs, including tuberculosis vaccine Bacille Calmette-Guérin (BCG) and polybacterial immunotherapy MV130. From viewpoint, illustrating mode action clinical evidence supports proposal that TIbVs should be considered next-generation confer protection range

Язык: Английский

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Epigenetic reprogramming of the host immune system during acute HIV

Current Opinion in HIV and AIDS, Год журнала: 2025, Номер 20(3), С. 209 - 217

Опубликована: Апрель 3, 2025

Purpose of review This explores the epigenetic mechanisms driving immune dysregulation during acute HIV, focusing on how early HIV exploits host machinery to establish viral persistence and evade clearance. Recent findings Epigenetic reprogramming plays a pivotal role in shaping responses, establishing reservoirs, persistent dysfunction. studies leveraging genome-wide DNA methylation profiling, single-cell transcriptomics, chromatin accessibility assays are elucidating key through which epigenome surveillance promote persistence. Summary is critical determinant Understanding these offers new avenues for therapeutic strategies aimed at modulating disrupt reservoir formation, enhance advance cure efforts.

Язык: Английский

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Hematopoietic stem cell state and fate in trained immunity

Cell Communication and Signaling, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 14, 2025

Язык: Английский

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