Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

Chemical Society Reviews, Год журнала: 2022, Номер 51(12), С. 4996 - 5041

Опубликована: Янв. 1, 2022

This review systematically summarizes the research status, challenges, prospects, and potential bench-to-bedside translation of minimally invasive nanomedicines.

Язык: Английский

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Near-infrared luminescence high-contrast in vivo biomedical imaging

Nature Reviews Bioengineering, Год журнала: 2023, Номер 1(1), С. 60 - 78

Опубликована: Янв. 19, 2023

Язык: Английский

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Hemicyanine‐Based Near‐Infrared Activatable Probes for Imaging and Diagnosis of Diseases

Angewandte Chemie International Edition, Год журнала: 2021, Номер 60(51), С. 26454 - 26475

Опубликована: Июль 15, 2021

Molecular activatable probes with near-infrared (NIR) fluorescence play a critical role in vivo imaging of biomarkers for drug screening and disease diagnosis. With structural diversity high quantum yields, hemicyanine dyes have emerged as versatile scaffold the construction optical probes. This Review presents survey hemicyanine-based NIR (HNAPs) early diagnosis diseases. The molecular design principles HNAPs towards signaling against various are discussed focus on their broad applications detection diseases including inflammation, acute organ failure, skin diseases, intestinal cancer. progress not only proves unique value preclinical research but also highlights translational potential clinical

Язык: Английский

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Carbon Dots in Bioimaging, Biosensing and Therapeutics: A Comprehensive Review

Small Science, Год журнала: 2022, Номер 2(6)

Опубликована: Май 8, 2022

Carbon dots (CDs), comprising crystalline graphitized carbon cores and polymer surface groups, are currently attracting a lot of interest in biological fields owing to their fluorescent properties, high photostability, biocompatibility low toxicity. In addition, the easy preparation functionalization CDs stimulate development CDs‐based composite materials with specific functions. Presently, applications growing at remarkable speed, justifying need for up‐to‐date review articles that capture recent progress this blossoming field. review, breakthroughs synthesis, modification, optical toxicology biocatalytic platforms described. Further, research related bioimaging, biosensing, drug delivery, antibacterial, anticancer (photothermal therapy, photodynamic therapy synergistic therapy) antiviral therapies involving discussed detail. Finally, perspective on prospects challenges biomedicine biotechnology is provided.

Язык: Английский

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Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance

ACS Nano, Год журнала: 2023, Номер 17(21), С. 20825 - 20849

Опубликована: Ноя. 3, 2023

Understanding the in vivo transport of nanoparticles provides guidelines for designing nanomedicines with higher efficacy and fewer side effects. Among many factors, size plays a key role controlling their behaviors due to existence various physiological thresholds within body size-dependent nano-bio interactions. Encouraged by evolving discoveries nanoparticle-size-dependent biological effects, we believe that it is necessary systematically summarize size-scaling laws nanoparticle vivo. In this review, summarized effect on along journey body: begin administration via different delivery routes, followed targeting intended tissues including tumors other organs, eventually clearance through liver or kidneys. We outlined tools investigating as well. Finally, discussed how may leverage tackle some challenges nanomedicine translation also raised important size-related questions remain be answered future.

Язык: Английский

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The Chemistry of Organic Contrast Agents in the NIR‐II Window

Angewandte Chemie International Edition, Год журнала: 2021, Номер 61(14)

Опубликована: Дек. 7, 2021

Abstract Optical imaging, especially fluorescence and photoacoustic is a non‐invasive imaging approach with high spatial temporal resolution sensitivity, compared to positron emission tomography (PET) or magnetic resonance (MRI). Due the merits of using second near‐infrared (NIR‐II) window, like deeper penetration depth, signal‐to‐noise ratio, resolution, low tissue damage, researchers have devoted great effort developing contrast agents NIR‐II absorption emission. In this Review, we summarize recently developed organic luminescent materials, ranging from small molecules conjugated polymers. Then, systematically introduce engineering strategies describe performance classified by skeleton cores. Finally, elucidate challenges prospects these dyes for potential clinical applications. We expect our summary can inspire expand spectrum diverse bioapplications.

Язык: Английский

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Chemical Design of Activatable Photoacoustic Probes for Precise Biomedical Applications

Chemical Reviews, Год журнала: 2022, Номер 122(6), С. 6850 - 6918

Опубликована: Март 2, 2022

Photoacoustic (PA) imaging technology, a three-dimensional hybrid modality that integrates the advantage of optical and acoustic imaging, has great application prospects in molecular due to its high depth resolution. To endow PA with ability for real-time visualization precise biomedical diagnosis, numerous activatable probes which can specifically alter their intensities upon reacting targets or biological events interest have been developed. This review highlights recent developments applications including detection biotargets events. First, generation mechanism signals will be given, followed by brief introduction contrast agents used probe design. Then we particularly summarize general design principles alteration strategies developing probes. Furthermore, give detailed discussion living systems. At last, current challenges outlooks future discussed. We hope this stimulate new ideas explore potentials future.

Язык: Английский

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Stimuli-activatable nanomedicine meets cancer theranostics

Theranostics, Год журнала: 2023, Номер 13(15), С. 5386 - 5417

Опубликована: Янв. 1, 2023

Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.Upon exposure to endogenous/exogenous stimuli, stimuli-activatable could be self-assembled, disassembled, or functionally activated improve its biosafety and diagnostic/therapeutic potency.A myriad tumor-specific features, including a low pH, high redox level, overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, radiation) have been considered nano-medicinal products.Recently, novel stimuli explored elegant designs emerged nanomedicine.In addition, multi-functional theranostic has employed imaging-guided image-assisted antitumor therapy.In this review, we rationalize development clinical pressing needs.Stimuli-activatable self-assembly, disassembly functional activation approaches developing realize better efficacy are elaborated state-of-the-art advances their structural detailed.A reflection, status, future perspectives provided.

Язык: Английский

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Recent Advances in Contrast-Enhanced Photoacoustic Imaging: Overcoming the Physical and Practical Challenges

Chemical Reviews, Год журнала: 2023, Номер 123(11), С. 7379 - 7419

Опубликована: Янв. 16, 2023

For decades now, photoacoustic imaging (PAI) has been investigated to realize its potential as a niche biomedical modality. Despite highly desirable optical contrast and ultrasonic spatiotemporal resolution, PAI is challenged by such physical limitations low signal-to-noise ratio (SNR), diminished image due strong attenuation, lower-bound on spatial resolution in deep tissue. In addition, contrast-enhanced faced practical insufficient cell-specific targeting delivery efficiency difficulties developing clinically translatable agents. Identifying these essential the continuing expansion of field, substantial advances contrast-enhancing agents, complemented high-performance acquisition systems, have synergistically dealt with challenges conventional PAI. This review covers past four years research pushing terms SNR/contrast, targeted delivery, clinical application. Promising strategies for dealing each challenge are reviewed detail, future directions next generation discussed.

Язык: Английский

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A Dual‐Locked Activatable Phototheranostic Probe for Biomarker‐Regulated Photodynamic and Photothermal Cancer Therapy

Angewandte Chemie International Edition, Год журнала: 2022, Номер 61(26)

Опубликована: Апрель 9, 2022

Activatable phototheranostics holds promise for precision cancer treatment owing to the "turn-on" signals and therapeutic effects. However, most activatable phototheranostic probes only possess photodynamic therapy (PDT) or photothermal (PTT), which suffer from poor efficacy due deficient cellular oxygen complex tumor microenvironment. We herein report a dual-locked probe that activates near-infrared fluorescence (NIRF) in tumor, triggers PDT response tumor-periphery biomarker, switches PTT upon detecting tumor-core-hypoxia biomarker. This PDT-PTT auto-regulated exhibits complete ablation under photoirradiation of single laser source by producing cytotoxic singlet at periphery generating hyperthermia tumor-core where is too hypoxic PDT. represents promising molecular design approach toward precise phototheranostics.

Язык: Английский

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