Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases

Nature Medicine, Год журнала: 2022, Номер 28(9), С. 1913 - 1923

Опубликована: Сен. 1, 2022

Fecal microbiota transplantation (FMT) is highly effective against recurrent Clostridioides difficile infection and considered a promising treatment for other microbiome-related disorders, but comprehensive understanding of microbial engraftment dynamics lacking, which prevents informed applications this therapeutic approach. Here, we performed an integrated shotgun metagenomic systematic meta-analysis new publicly available stool microbiomes collected from 226 triads donors, pre-FMT recipients post-FMT across eight different disease types. By leveraging improved strain-profiling to infer strain sharing, found that with higher donor were more likely experience clinical success after FMT (P = 0.017) when evaluated studies. Considering all cohorts, increased was noted in individuals receiving multiple routes (for example, both via capsules colonoscopy during the same treatment) as well antibiotic-treated infectious diseases compared antibiotic-naïve patients noncommunicable diseases. Bacteroidetes Actinobacteria species (including Bifidobacteria) displayed than Firmicutes except six under-characterized species. Cross-dataset machine learning predicted presence or absence recipient at 0.77 average AUROC leave-one-dataset-out evaluation, highlighted relevance abundance, prevalence taxonomy presence. exploring microbiome their association variables, our study uncovered species-specific patterns presented models able predict donors might optimize specific characteristics disease-targeted protocols.

Язык: Английский

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Gut bacterial profiles in Parkinson's disease: A systematic review

CNS Neuroscience & Therapeutics, Год журнала: 2022, Номер 29(1), С. 140 - 157

Опубликована: Окт. 25, 2022

Abstract Introduction Recent advances have highlighted the relationships between gut dysbiosis and Parkinson's disease (PD). Microbiota transplantation from PD patients to mice can induce increased alpha‐synuclein‐mediated motor deficits. Human studies identified differences in microbiota of compared healthy controls. We undertook a systematic review evaluate available evidence for involvement bacteria etiology PD. Methods The PubMed databank, China National Knowledge Infrastructure Wanfang Data were searched inception until June 2021 identify human case–control that investigated quantified feces. evaluated resulting focusing on bacterial taxa different Results Twenty‐six found which 53 microbial families 98 genera exhibited with by more than two as Bifidobacterium , Alistipes Christensenella Enterococcus Oscillospira Bilophila Desulfovibrio Escherichia/Shigella Akkermansia while Prevotella Blautia Faecalibacterium Fusicatenibacter Haemophilus had three or reports being lower patients. More one report demonstrated Bacteroides Odoribacter Parabacteroides Butyricicoccus Butyrivibrio Clostridium Coprococcus Lachnospira Lactobacillus Megasphaera Phascolarctobacterium Roseburia Ruminococcus Streptococcus Klebsiella altered both directions. Conclusion Our shows microbiome may involve alterations short‐chain fatty acids (SCFAs)‐producing an increase putative pathobionts. SCFAs‐producing vary above below “optimal range,” causing imbalances. Considering are beneficial health, be associated medications, especially COMT inhibitors, high level aging.

Язык: Английский

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Prevotella: A Key Player in Ruminal Metabolism

Microorganisms, Год журнала: 2022, Номер 11(1), С. 1 - 1

Опубликована: Дек. 20, 2022

Ruminants are foregut fermenters that have the remarkable ability of converting plant polymers indigestible to humans into assimilable comestibles like meat and milk, which cornerstones human nutrition. establish a symbiotic relationship with their microbiome, latter is workhorse carbohydrate fermentation. On other hand, during fermentation, synthesis propionate sequesters H, thus reducing its availability for ultimate production methane (CH4) by methanogenic archaea. Biochemically, simplest alkane represents downturn in energetic efficiency ruminants; environmentally, it constitutes potent greenhouse gas negatively affects climate change. Prevotella very versatile microbe capable processing wide range proteins polysaccharides, one fermentation products propionate, trait appears conspicuous P. ruminicola strain 23. Since but not acetate or butyrate, an H sink, propionate-producing microbes potential reduce production. Accordingly, numerous studies suggest members genus divert hydrogen flow glycolysis away from methanogenesis favor propionic acid Intended broad audience microbiology, our review summarizes biochemistry subsequently discusses evidence supporting essential role lignocellulose association reduced emissions. We hope this article will serve as introduction novice researchers update others more conversant topic.

Язык: Английский

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Oral Prevotella Species and Their Connection to Events of Clinical Relevance in Gastrointestinal and Respiratory Tracts

Frontiers in Microbiology, Год журнала: 2022, Номер 12

Опубликована: Янв. 6, 2022

Prevotella is recognized as one of the core anaerobic genera in oral microbiome. In addition, members this genus belong to microbial communities gastrointestinal and respiratory tracts. Several novel species, most them origin, have been described, but limited knowledge still available their clinical relevance. melaninogenica among commensals on mucosae from early months life onward, other colonizing species cavity include nigrescens pallens . Oral get constant access tract via saliva swallowing lower airways microaspiration. At these extra-oral sites, they play a role also potentially harmful agents mucosal surfaces. The aim narrative review give an updated overview involvement health disease.

Язык: Английский

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Prevotella species as oral residents and infectious agents with potential impact on systemic conditions

Journal of Oral Microbiology, Год журнала: 2022, Номер 14(1)

Опубликована: Май 26, 2022

Oral Prevotella are known as anaerobic commensals on oral mucosae and in dental plaques from early life onwards, including pigmented P. melaninogenica, nigrescens, pallens non-pigmented species. Many species contribute to inflammatory processes, being frequent findings dysbiotic biofilms of periodontal diseases (P. intermedia, nigrescens), cariotic lesions denticola, Alloprevotella (formerly Prevotella) tannerae), endodontic infections baroniae, oris, multisaccharivorax), other clinically relevant conditions. Over the years, several novel have been recovered cavity without knowledge their clinical relevance. Within this wide genus, virulence properties characteristics like biofilm formation seemingly vary a species- strain-dependent manner, shown for intermedia group organisms aurantiaca, pallens). identified various non-oral chronic pathological Here, we updated genus role residents infectious agents cavity, well detection infections, but also gathered information potential link cancers head neck, systemic disorders.

Язык: Английский

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Cardiometabolic health, diet and the gut microbiome: a meta-omics perspective

Nature Medicine, Год журнала: 2023, Номер 29(3), С. 551 - 561

Опубликована: Март 1, 2023

Язык: Английский

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Genomic repertoires linked with pathogenic potency of arthritogenicPrevotella copriisolated from the gut of patients with rheumatoid arthritis

Annals of the Rheumatic Diseases, Год журнала: 2023, Номер 82(5), С. 621 - 629

Опубликована: Янв. 10, 2023

Objectives Prevotella copri is considered to be a contributing factor in rheumatoid arthritis (RA). However, some non-Westernised countries, healthy individuals also harbour an abundance of P. the intestine. This study investigated pathogenicity RA patient-derived ( ) compared with control-derived HC ). Methods We obtained 13 P . strains from faeces patients and controls. Following whole genome sequencing, sequences were compared. To analyse arthritis-inducing ability , we examined two models (1) collagen-induced model harbouring under specific-pathogen-free conditions (2) SKG mouse -monocolonised conditions. Finally, evaluate activate innate immune cells, performed vitro stimulation bone marrow-derived dendritic cells (BMDCs) by Results Comparative genomic analysis revealed no apparent differences core gene contents between but pangenome high plasticity identified -specific region as conjugative transposon. In both models, -induced more severe than BMDC experiments upregulation IL-17 Th17-related cytokines (IL-6, IL-23) Conclusion Our findings reveal genetic diversity signatures associated strong contributes towards elucidation complex pathogenesis RA.

Язык: Английский

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Mycotoxin deoxynivalenol-induced intestinal flora disorders, dysfunction and organ damage in broilers and pigs

Journal of Hazardous Materials, Год журнала: 2023, Номер 451, С. 131172 - 131172

Опубликована: Март 7, 2023

Язык: Английский

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Fermented foods, their microbiome and its potential in boosting human health

Microbial Biotechnology, Год журнала: 2024, Номер 17(2)

Опубликована: Фев. 1, 2024

Fermented foods (FFs) are part of the cultural heritage several populations, and their production dates back 8000 years. Over last ~150 years, microbial consortia many most widespread FFs have been characterised, leading in some instances to standardisation production. Nevertheless, limited knowledge exists about communities local traditional possible effects on human health. Recent findings suggest they might be a valuable source novel probiotic strains, enriched nutrients highly sustainable for environment. Despite increasing number observational studies randomised controlled trials, it still remains unclear whether how regular FF consumption is linked with health outcomes enrichment gut microbiome health-associated species. This review aims sum up associated microbiomes, outlining role fermentation respect boosting nutritional profiles attempting establish link between health-beneficial outcomes.

Язык: Английский

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Diet-Induced Gut Dysbiosis and Leaky Gut Syndrome

Journal of Microbiology and Biotechnology, Год журнала: 2024, Номер 34(4), С. 747 - 756

Опубликована: Фев. 1, 2024

Язык: Английский

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