Environmental Science & Technology,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 16, 2024
The
occurrence
of
biofouling
restricts
the
widespread
application
membrane
bioreactors
(MBRs)
in
wastewater
treatment.
Regulation
quorum
sensing
(QS)
is
a
promising
approach
to
control
MBRs,
yet
underlying
mechanisms
are
complex
and
remain
be
illustrated.
A
fundamental
understanding
relationship
between
QS
MBRs
lacking,
which
hampers
development
quenching
(QQ)
techniques
(QQMBRs).
While
many
QQ
microorganisms
have
been
isolated
thus
far,
critical
criteria
for
selecting
desirable
still
missing.
Furthermore,
there
inconsistent
results
regarding
lifecycle
effects
on
physicochemical
characteristics
microbial
communities
mixed
liquor
assemblages
QQMBRs,
might
result
unreliable
inefficient
applications.
This
review
aims
comprehensively
summarize
timely
research
highlight
important
often
ignored
perspectives
MBRs.
We
consider
what
this
"information"
can
cannot
tell
us
explore
its
values
addressing
specific
questions
QQMBRs.
Herein,
we
first
examine
current
analytical
methods
signals
discuss
roles
fouling-forming
cornerstones
technologies.
To
achieve
targeting
strategies
propose
substrate
specificity
degradation
capability
surface
area
pore
structures
media
as
select
functional
microbes
media,
respectively.
validate
retardation
efficiency,
further
specify
properties,
community
composition,
succession
Finally,
provide
scale-up
considerations
QQMBRs
terms
debated
lifecycle,
practical
synergistic
strategies,
potential
cost
savings
presents
limitations
classic
QS/QQ
hypotheses
advances
role
development/retardation
builds
bridge
understandings
applications
technology.
Infection and Drug Resistance,
Год журнала:
2023,
Номер
Volume 16, С. 7515 - 7545
Опубликована: Дек. 1, 2023
Abstract:
Antimicrobial
resistance,
referring
to
microorganisms'
capability
subsist
and
proliferate
even
when
there
are
antimicrobials
is
a
foremost
threat
public
health
globally.
The
appearance
of
antimicrobial
resistance
can
be
ascribed
anthropological,
animal,
environmental
factors.
Human-related
causes
include
overuse
misuse
in
medicine,
antibiotic-containing
cosmetics
biocides
utilization,
inadequate
sanitation
hygiene
settings.
Prophylactic
therapeutic
overuse,
using
as
feed
additives,
microbes
resistant
antibiotics
genes
animal
excreta,
residue
found
animal-origin
food
excreta
animals
related
contributive
factors
for
the
antibiotic
emergence
spread.
Environmental
including
naturally
existing
genes,
improper
disposal
unused
antimicrobials,
contamination
from
waste
settings,
farms,
pharmaceutical
industries,
use
agricultural
chemicals
facilitatet
its
Wildlife
has
plausible
role
Adopting
one-health
approach
involving
properly
humans,
improving
spaces
implementing
coordinated
governmental
regulations
crucial
combating
resistance.
Collaborative
cooperative
involvement
stakeholders
public,
veterinary
ecological
sectors
circumvent
problem
effectively.
Keywords:
one
health,
gene,
environment,
wildlife
Cell Reports,
Год журнала:
2023,
Номер
42(7), С. 112672 - 112672
Опубликована: Июнь 21, 2023
Prokaryotic
adaptation
is
strongly
influenced
by
the
horizontal
acquisition
of
beneficial
traits
via
mobile
genetic
elements
(MGEs),
such
as
viruses/bacteriophages
and
plasmids.
However,
MGEs
can
also
impose
a
fitness
cost
due
to
their
often
parasitic
nature
differing
evolutionary
trajectories.
In
response,
prokaryotes
have
evolved
diverse
immune
mechanisms
against
MGEs.
Recently,
our
understanding
abundance
diversity
prokaryotic
systems
has
greatly
expanded.
These
defense
degrade
invading
material,
inhibit
genome
replication,
or
trigger
abortive
infection,
leading
population
protection.
this
review,
we
highlight
these
strategies,
focusing
on
most
recent
discoveries.
The
study
defenses
not
only
sheds
light
microbial
evolution
but
uncovers
novel
enzymatic
activities
with
promising
biotechnological
applications.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 31, 2024
Drug-resistant
Staphylococcus
aureus
stands
as
a
prominent
pathogen
in
nosocomial
and
community-acquired
infections,
capable
of
inciting
various
infections
at
different
sites
patients.
This
includes
bacteremia
(SaB),
which
exhibits
severe
infection
frequently
associated
with
significant
mortality
rate
approximately
25%.
In
the
absence
better
alternative
therapies,
antibiotics
is
still
main
approach
for
treating
infections.
However,
excessive
use
has,
turn,
led
to
an
increase
antimicrobial
resistance.
Hence,
it
imperative
that
new
strategies
are
developed
control
drug-resistant
S.
Bacteriophages
viruses
ability
infect
bacteria.
Bacteriophages,
were
used
treat
bacterial
before
advent
antibiotics,
but
subsequently
replaced
by
due
limited
theoretical
understanding
inefficient
preparation
processes
time.
Recently,
phages
have
attracted
attention
many
researchers
again
because
serious
problem
antibiotic
article
provides
comprehensive
overview
phage
biology,
animal
models,
diverse
clinical
case
treatments,
trials
context
therapy.
It
also
assesses
strengths
limitations
therapy
outlines
future
prospects
research
directions.
review
expected
offer
valuable
insights
engaged
phage-based
treatments
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Май 29, 2024
Abstract
Bacterial
pathogens
carrying
multidrug
resistance
(MDR)
plasmids
are
a
major
threat
to
human
health.
The
acquisition
of
antibiotic
genes
(ARGs)
in
is
often
facilitated
by
mobile
genetic
elements
that
copy
or
translocate
ARGs
between
DNA
molecules.
agglomeration
generates
islands
comprising
multiple
ARGs.
However,
whether
the
emergence
restricted
specific
MDR
plasmid
lineages
remains
understudied.
Here
we
show
biased
towards
large
lineages.
Analyzing
6784
2441
Escherichia
,
Salmonella
and
Klebsiella
isolates,
quantify
84%
found
islands.
We
furthermore
observe
rapid
evolution
ARG
combinations
Most
regions
identified
as
shared
among
closely
related
but
rarely
distantly
plasmids.
Our
results
suggest
presence
barriers
for
dissemination
lineages,
which
properties,
host
range
evolutionary
history.
attributed
workings
operate
within
framework
existing
