Molecular Cell, Год журнала: 2023, Номер 84(1), С. 34 - 54
Опубликована: Ноя. 13, 2023
Язык: Английский
Mutation Research/Reviews in Mutation Research, Год журнала: 2021, Номер 787, С. 108365 - 108365
Опубликована: Янв. 1, 2021
Язык: Английский
Процитировано
389
Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)
Опубликована: Май 13, 2023
Abstract Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms are linked to innate adaptive immune dysfunction that accompanies aging (known as immunosenescence). During aging, organisms tend develop a characteristic inflammatory state expresses high levels of pro-inflammatory markers, termed inflammaging. This chronic inflammation is typical phenomenon immunosenescence it considered the major risk factor for diseases. Thymic involution, naïve/memory cell ratio imbalance, dysregulated metabolism, epigenetic alterations striking features immunosenescence. Disturbed T-cell pools antigen stimulation mediate premature senescence cells, senescent cells proinflammatory senescence-associated secretory phenotype exacerbates Although underlying molecular mechanisms remain be addressed, well documented T inflammaging might driving forces in Potential counteractive measures will discussed, including intervention cellular metabolic-epigenetic axes mitigate In recent years, has attracted increasing attention its role tumor development. As result limited participation elderly patients, impact on cancer immunotherapy unclear. Despite some surprising results from clinical trials drugs, necessary investigate other
Язык: Английский
Процитировано
314
Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)
Опубликована: Ноя. 7, 2022
Abstract Aging is accompanied by the decline of organismal functions and a series prominent hallmarks, including genetic epigenetic alterations. These aging-associated changes include DNA methylation, histone modification, chromatin remodeling, non-coding RNA (ncRNA) regulation, all which participate in regulation aging process, hence contribute to aging-related diseases. Therefore, understanding mechanisms will provide new avenues develop strategies delay aging. Indeed, interventions based on manipulating have led alleviation or extension lifespan animal models. Small molecule-based therapies reprogramming that enable rejuvenation been developed for ameliorating reversing conditions. In addition, adopting health-promoting activities, such as caloric restriction, exercise, calibrating circadian rhythm, has demonstrated Furthermore, various clinical trials intervention are ongoing, providing more evidence safety efficacy these therapies. Here, we review recent work outline advances age-associated A better critical roles epigenetics process lead prevention human therapy
Язык: Английский
Процитировано
299
eLife, Год журнала: 2021, Номер 10
Опубликована: Май 13, 2021
Aging is a complex biological process characterized by hallmark features accumulating over the life course, shaping individual's aging trajectory and subsequent disease risks. There substantial individual variability in between men women. In general, women live longer than men, consistent with lower ages as assessed molecular biomarkers, but there paradox. Women are frailer have worse health at end of life, while still perform better physical function examinations. Moreover, many age-related diseases show sex-specific patterns. this review, we aim to summarize current knowledge on sexual dimorphism human studies, support from animal research, illnesses. We also attempt place it context theories aging, well discuss explanations for sex differences, example, sex-chromosome linked mechanisms hormonally driven differences.
Язык: Английский
Процитировано
295
Cell, Год журнала: 2020, Номер 180(5), С. 984 - 1001.e22
Опубликована: Фев. 27, 2020
Язык: Английский
Процитировано
274
Nature Neuroscience, Год журнала: 2021, Номер 24(3), С. 331 - 342
Опубликована: Фев. 22, 2021
Язык: Английский
Процитировано
271
Science China Life Sciences, Год журнала: 2022, Номер 65(12), С. 2354 - 2454
Опубликована: Сен. 2, 2022
Язык: Английский
Процитировано
239
Signal Transduction and Targeted Therapy, Год журнала: 2021, Номер 6(1)
Опубликована: Июнь 28, 2021
Remarkable progress in ageing research has been achieved over the past decades. General perceptions and experimental evidence pinpoint that decline of physical function often initiates by cell senescence organ ageing. Epigenetic dynamics immunometabolic reprogramming link to alterations cellular response intrinsic extrinsic stimuli, representing current hotspots as they not only (re-)shape individual identity, but also involve fate decision. This review focuses on present findings emerging concepts epigenetic, inflammatory, metabolic regulations consequences process. Potential therapeutic interventions targeting regulatory mechanisms, using state-of-the-art techniques are discussed.
Язык: Английский
Процитировано
227
Nucleic Acids Research, Год журнала: 2020, Номер 49(D1), С. D825 - D830
Опубликована: Сен. 30, 2020
Organismal aging is driven by interconnected molecular changes encompassing internal and extracellular factors. Combinational analysis of high-throughput 'multi-omics' datasets (gathering information from genomics, epigenomics, transcriptomics, proteomics, metabolomics pharmacogenomics), at either populational or single-cell levels, can provide a multi-dimensional, integrated profile the heterogeneous process with unprecedented throughput detail. These new strategies allow for exploration regulatory status gene expression during aging, in turn, facilitate development interventions. With continually growing volume valuable aging-related data, it necessary to establish an open database support wide spectrum research. The Aging Atlas aims range life science researchers resources that access large-scale regulation created various omics technologies. current implementation includes five modules: transcriptomics (RNA-seq), (scRNA-seq), epigenomics (ChIP-seq), proteomics (protein-protein interaction), pharmacogenomics (geroprotective compounds). provides user-friendly functionalities explore age-related expression, as well raw data download services. freely available https://bigd.big.ac.cn/aging/index.
Язык: Английский
Процитировано
216
Cell, Год журнала: 2023, Номер 186(2), С. 287 - 304.e26
Опубликована: Янв. 1, 2023
Whether and how certain transposable elements with viral origins, such as endogenous retroviruses (ERVs) dormant in our genomes, can become awakened contribute to the aging process is largely unknown. In human senescent cells, we found that HERVK (HML-2), most recently integrated ERVs, are unlocked transcribe genes produce retrovirus-like particles (RVLPs). These RVLPs constitute a transmissible message elicit senescence phenotypes young which be blocked by neutralizing antibodies. The activation of ERVs was also observed organs aged primates mice well tissues serum from elderly. Their repression alleviates cellular tissue degeneration and, some extent, organismal aging. findings indicate resurrection hallmark driving force
Язык: Английский
Процитировано
207