Atherosclerosis: Recent developments

Cell, Год журнала: 2022, Номер 185(10), С. 1630 - 1645

Опубликована: Май 1, 2022

Atherosclerosis is an inflammatory disease of the large arteries that major cause cardiovascular (CVD) and stroke. Here, we review current understanding molecular, cellular, genetic, environmental contributions to atherosclerosis, from both individual pathway systems perspectives. We place emphasis on recent developments, some which have yielded unexpected biology, including previously unknown heterogeneity smooth muscle cells in atherosclerotic lesions, roles for senescence clonal hematopoiesis, links gut microbiome.

Язык: Английский

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Modulation of cellular processes by histone and non-histone protein acetylation

Nature Reviews Molecular Cell Biology, Год журнала: 2022, Номер 23(5), С. 329 - 349

Опубликована: Янв. 18, 2022

Язык: Английский

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Molecular mechanisms of dietary restriction promoting health and longevity

Nature Reviews Molecular Cell Biology, Год журнала: 2021, Номер 23(1), С. 56 - 73

Опубликована: Сен. 13, 2021

Язык: Английский

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The metabolic roots of senescence: mechanisms and opportunities for intervention

Nature Metabolism, Год журнала: 2021, Номер 3(10), С. 1290 - 1301

Опубликована: Окт. 18, 2021

Язык: Английский

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The diverse functionality of NQO1 and its roles in redox control

Redox Biology, Год журнала: 2021, Номер 41, С. 101950 - 101950

Опубликована: Март 21, 2021

In this review, we summarize the multiple functions of NQO1, its established roles in redox processes and potential control that are currently emerging. NQO1 has attracted interest due to cell defense marked inducibility during cellular stress. Exogenous substrates for include many xenobiotic quinones. Since is highly expressed solid tumors, including via upregulation Nrf2, design compounds activated by NQO1-targeted drug delivery have been active areas research. Endogenous also proposed relevance stress ubiquinone vitamin E quinone, components plasma membrane system. Established a superoxide reductase activity, NAD+ generation, interaction with proteins their stabilization against proteasomal degradation, binding regulation mRNA translation microtubules mitotic spindles. We glucose insulin metabolism diabetes metabolic syndrome, Alzheimer's disease aging. The conformation molecular interactions can be modulated changes pyridine nucleotide balance suggesting may function as redox-dependent switch.

Язык: Английский

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SARS-CoV-2, COVID-19 and the aging immune system

Nature Aging, Год журнала: 2021, Номер 1(9), С. 769 - 782

Опубликована: Сен. 14, 2021

Язык: Английский

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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Фев. 16, 2024

Abstract The human gastrointestinal tract is populated with a diverse microbial community. vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect biology, including health maintenance, development, aging, disease. advent new sequencing technologies culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations shed light on microbiome–host interactions. Evidence unveiled bidirectional communication between central nervous system, referred as “microbiota–gut–brain axis”. microbiota–gut–brain axis represents an important regulator glial functions, making it actionable target ameliorate development progression neurodegenerative diseases. In this review, we discuss mechanisms As provides essential cues microglia, astrocytes, oligodendrocytes, examine communications microbiota these cells during healthy states Subsequently, diseases using metabolite-centric approach, while also examining role microbiota-related neurotransmitters hormones. Next, targeting intestinal barrier, blood–brain meninges, peripheral immune system counteract dysfunction neurodegeneration. Finally, conclude by assessing pre-clinical clinical evidence probiotics, prebiotics, fecal transplantation A thorough comprehension will foster effective therapeutic interventions for management

Язык: Английский

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The landscape of aging

Science China Life Sciences, Год журнала: 2022, Номер 65(12), С. 2354 - 2454

Опубликована: Сен. 2, 2022

Язык: Английский

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New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary

Aging, Год журнала: 2022, Номер 14(16), С. 6829 - 6839

Опубликована: Авг. 29, 2022

Aging | doi:10.18632/aging.204248. Tomas Schmauck-Medina, Adrian Molière, Sofie Lautrup, Jianying Zhang, Stefan Chlopicki, Helena Borland Madsen, Shuqin Cao, Casper Soendenbroe, Els Mansell, Mark Bitsch Vestergaard, Zhiquan Li, Yosef Shiloh, Patricia L. Opresko, Jean-Marc Egly, Thomas Kirkwood, Eric Verdin, Vilhelm A. Bohr, Lynne S. Cox, Tinna Stevnsner, Lene Juel Rasmussen, Evandro F. Fang

Язык: Английский

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Ageing and rejuvenation of tissue stem cells and their niches

Nature Reviews Molecular Cell Biology, Год журнала: 2022, Номер 24(1), С. 45 - 62

Опубликована: Июль 20, 2022

Язык: Английский

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