Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Апрель 22, 2022
Targeting
ferroptosis,
a
unique
cell
death
modality
triggered
by
unrestricted
lipid
peroxidation,
in
cancer
therapy
is
hindered
our
incomplete
understanding
of
ferroptosis
mechanisms
under
specific
genetic
contexts.
KEAP1
(kelch-like
ECH
associated
protein
1)
frequently
mutated
or
inactivated
lung
cancers,
and
mutant
cancers
are
refractory
to
most
therapies,
including
radiotherapy.
In
this
study,
we
identify
suppressor
1
(FSP1,
also
known
as
AIFM2)
transcriptional
target
nuclear
factor
erythroid
2-related
2
(NRF2)
reveal
that
the
ubiquinone
(CoQ)-FSP1
axis
mediates
ferroptosis-
radiation-
resistance
deficient
cells.
We
further
show
pharmacological
inhibition
CoQ-FSP1
sensitizes
cells
patient-derived
xenograft
tumors
radiation
through
inducing
ferroptosis.
Together,
study
identifies
key
downstream
effector
KEAP1-NRF2
pathway
potential
therapeutic
for
treating
cancers.
Cell,
Год журнала:
2022,
Номер
185(14), С. 2401 - 2421
Опубликована: Июль 1, 2022
Ferroptosis,
a
form
of
cell
death
driven
by
iron-dependent
lipid
peroxidation,
was
identified
as
distinct
phenomenon
and
named
decade
ago.
Ferroptosis
has
been
implicated
in
broad
set
biological
contexts,
from
development
to
aging,
immunity,
cancer.
This
review
describes
key
regulators
this
within
framework
metabolism,
ROS
biology,
iron
biology.
Key
concepts
major
unanswered
questions
the
ferroptosis
field
are
highlighted.
The
next
promises
yield
further
breakthroughs
mechanisms
governing
additional
ways
harnessing
for
therapeutic
benefit.
The Journal of Experimental Medicine,
Год журнала:
2021,
Номер
218(6)
Опубликована: Май 12, 2021
Ferroptosis
is
a
type
of
regulated
necrosis
that
triggered
by
combination
iron
toxicity,
lipid
peroxidation,
and
plasma
membrane
damage.
The
upstream
inducers
ferroptosis
can
be
divided
into
two
categories
(biological
versus
chemical)
activate
major
pathways
(the
extrinsic/transporter
the
intrinsic/enzymatic
pathways).
Excessive
or
deficient
ferroptotic
cell
death
implicated
in
growing
list
physiological
pathophysiological
processes,
coupled
to
dysregulated
immune
response.
This
review
focuses
on
new
discoveries
related
how
cells
their
spilled
contents
shape
innate
adaptive
immunity
health
disease.
Understanding
immunological
characteristics
activity
not
only
illuminates
an
intersection
between
but
may
also
lead
development
novel
treatment
approaches
for
immunopathological
diseases.
