Nature Reviews Genetics, Год журнала: 2024, Номер unknown
Опубликована: Авг. 13, 2024
Язык: Английский
Nature Reviews Molecular Cell Biology, Год журнала: 2024, Номер 25(5), С. 396 - 415
Опубликована: Янв. 19, 2024
Язык: Английский
Процитировано
97
Cell, Год журнала: 2022, Номер 185(21), С. 3913 - 3930.e19
Опубликована: Окт. 1, 2022
Язык: Английский
Процитировано
85
Nucleus, Год журнала: 2022, Номер 13(1), С. 238 - 278
Опубликована: Ноя. 20, 2022
Access to DNA is a prerequisite the execution of essential cellular processes that include transcription, replication, chromosomal segregation, and repair. How proteins regulate these function in context chromatin its dynamic architectures an intensive field study. Over past decade, genome-wide assays new imaging approaches have enabled greater understanding how access genome regulated by nucleosomes associated proteins. Additional mechanisms may control accessibility vivo compaction phase separation – are beginning be understood. Here, we review ongoing development measurements, summarize different molecular structural shape landscape, detail many important biological functions linked accessibility.
Язык: Английский
Процитировано
74
Cell stem cell, Год журнала: 2023, Номер 30(12), С. 1569 - 1584
Опубликована: Окт. 18, 2023
Studies of mammalian development have advanced our understanding the genetic, epigenetic, and cellular processes that orchestrate embryogenesis uncovered new insights into unique aspects human embryogenesis. Recent studies now produced first epigenetic maps early embryogenesis, stimulating ideas about reprogramming, cell fate control, potential mechanisms underpinning developmental plasticity in embryos. In this review, we discuss these regulation importance for safeguarding development. We also highlight unanswered questions key challenges remain to be addressed.
Язык: Английский
Процитировано
45
Nature Reviews Genetics, Год журнала: 2024, Номер unknown
Опубликована: Авг. 12, 2024
The DNA methylation field has matured from a phase of discovery and genomic characterization to one seeking deeper functional understanding how this modification contributes development, ageing disease. In particular, the past decade seen many exciting mechanistic discoveries that have substantially expanded our appreciation for generic, evolutionarily ancient can be incorporated into robust epigenetic codes. Here, we summarize current distinct landscapes emerge over mammalian lifespan discuss they interact with other regulatory layers support diverse functions. We then review rising interest in alternative patterns found during senescence somatic transition cancer. Alongside advancements single-cell long-read sequencing technologies, collective insights made across these fields offer new opportunities connect biochemical genetic features cell physiology, developmental potential phenotype. Review, Smith et al. describe development within key disease states, as well different methyltransferases interface histone modifications proteins create maintain them.
Язык: Английский
Процитировано
37
Science Advances, Год журнала: 2024, Номер 10(18)
Опубликована: Май 3, 2024
In mammals, males and females show marked differences in immune responses. Males are globally more sensitive to infectious diseases, while susceptible systemic autoimmunity. X-chromosome inactivation (XCI), the epigenetic mechanism ensuring silencing of one X females, may participate these sex biases. We perturbed expression trigger XCI, noncoding RNA Xist , female mice. This resulted reactivation genes on inactive X, including members Toll-like receptor 7 (TLR7) signaling pathway, monocyte/macrophages dendritic B cells. Consequently, mice spontaneously developed inflammatory signs typical lupus, anti–nucleic acid autoantibodies, increased frequencies age-associated germinal center cells, expansion Mechanistically, TLR7 is dysregulated macrophages, leading sustained target upon stimulation. These findings provide a direct link between maintenance XCI female-biased autoimmune manifestations highlight altered as cause
Язык: Английский
Процитировано
30
Science Advances, Год журнала: 2025, Номер 11(10)
Опубликована: Март 5, 2025
Women live longer than men and exhibit less cognitive aging. The X chromosome contributes to sex differences, as females harbor an inactive (Xi) active (Xa), in contrast males with only Xa. Thus, reactivation of silent Xi genes may contribute differences. We use allele-specific, single-nucleus RNA sequencing show that aging remodels transcription the Xa across hippocampal cell types. Aging preferentially changed gene expression on X's relative autosomes. Select underwent activation, new escape cells including dentate gyrus, critical learning memory. Expression escapee Plp1, a myelin component, was increased hippocampus female mice parahippocampus women. AAV-mediated Plp1 elevation gyrus male improved cognition. Understanding how confer advantage could lead novel targets counter brain disease both sexes.
Язык: Английский
Процитировано
8
Trends in Genetics, Год журнала: 2022, Номер 39(2), С. 125 - 139
Опубликована: Сен. 19, 2022
Mitochondria, organelles that harbor their own circular genomes, are critical for energy production and homeostasis maintenance in eukaryotic cells. Recent studies discovered hundreds of mitochondria-encoded noncoding RNAs (mt-ncRNAs), including novel subtypes (mecciRNAs) double-stranded (mt-dsRNAs). Here, we discuss the emerging field mt-ncRNAs by reviewing expression patterns, biogenesis, metabolism, regulatory roles, functional mechanisms. Many have roles cellular physiology, some associated with, or even act as, causal factors human diseases. We also highlight developments technologies methodologies further insights into future perspectives challenges studying these RNAs, as well potential biomedical applications.
Язык: Английский
Процитировано
47
Journal of Autoimmunity, Год журнала: 2023, Номер 137, С. 102992 - 102992
Опубликована: Янв. 12, 2023
Язык: Английский
Процитировано
30
Molecular Cancer, Год журнала: 2023, Номер 22(1)
Опубликована: Фев. 7, 2023
Abstract Eukaryotic genomes are prevalently transcribed into many types of RNAs that translate proteins or execute gene regulatory functions. Many associate with chromatin directly indirectly and called chromatin-associated (caRNAs). To date, caRNAs have been found to be involved in transcriptional regulation through multiple mechanisms important roles different cancers. In this review, we first present categories the modes interaction between chromatin. We then detail nascent RNAs, noncoding emerging m 6 A on transcription regulation. Finally, discuss cancer as well epigenetic epitranscriptomic contributing cancer, which could provide insights relationship tumor treatment intervention.
Язык: Английский
Процитировано
30