Molecular Biology Reports,
Год журнала:
2025,
Номер
52(1)
Опубликована: Янв. 16, 2025
Cell
communication
and
competition
pathways
are
malleable
to
Myocardial
Infarction
(MI).
Key
signals,
transcriptive
regulators,
metabolites
associated
with
apoptotic
responses
such
as
Myc,
mTOR,
p53
important
players
in
the
myocardium.
The
individual
state
of
cardiomyocytes,
fibroblasts,
macrophages
heart
tissue
adaptable
times
stress.
overlapping
Wnt/β-catenin,
Notch,
c-Kit
exhibit
involvement
factors
cell
Depending
on
effects
these
genetic
expression
signal
amplification,
proliferative
capacities
previously
stated
cells
that
make
up
myocardium,
amplify
or
diminish.
This
creates
a
distinct
classification
"fit"
"unfit"
cells.
Beyond
straightforward
traits,
intricate
metabolite
interactions
between
neighboring
unveil
complex
battle.
Strategic
manipulation
holds
translational
promise
for
rapid
cardiac
recovery
post-trauma.
Theranostics,
Год журнала:
2023,
Номер
13(5), С. 1607 - 1631
Опубликована: Янв. 1, 2023
Nasopharyngeal
carcinoma
(NPC)
is
a
particular
entity
of
head
neck
cancer
that
generally
regarded
as
genetic
disease
with
diverse
intertumor
and
intratumor
heterogeneity.
This
perspective
review
mainly
outlines
the
up-to-date
knowledge
ecology
NPC
progression,
presents
number
conceptual
stepping-stones.
At
beginning,
I
explicitly
advocate
nature
(cancer)
not
but
an
ecological
disease:
multidimensional
spatiotemporal
"unity
evolution"
pathological
ecosystem.
The
hallmarks
proposed
to
act
factors
population
fitness.
Subsequently,
cells
are
described
invasive
species
its
metastasis
multidirectional
dispersal.
foundational
principles
include
intraspecific
relationship
(e.g.
communication)
interspecific
competition,
predation,
parasitism
mutualism)
interpreted
understand
progression.
"Mulberry-fish-ponds"
model
can
well
illustrate
dynamic
reciprocity
Tumor-host
interface
transition
zone
cancer,
tumor
buddings
should
be
recognized
islands
separated
from
mainland.
It
noted
tumor-host
has
significantly
molecular
functional
edge
effect
because
curvature
irregularity.
Selection
driving
therapy
including
hyperthermia
for
patients,
future
perspectives
in
such
field
"ecological
pathology",
"multidimensional
tumoriecology"
also
discussed.
advance
"nothing
evolution
or
makes
sense
except
light
other".
tree
constructed
comprehensively
point
out
research
direction.
Taken
together,
establishment
theory
might
provide
novel
framework
paradigm
our
understanding
complex
causal
process
potential
preventive
therapeutic
applications
patients.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Июнь 18, 2024
Abstract
Tumorigenesis
is
a
multistep
process,
with
oncogenic
mutations
in
normal
cell
conferring
clonal
advantage
as
the
initial
event.
However,
despite
pervasive
somatic
and
expansion
tissues,
their
transformation
into
cancer
remains
rare
event,
indicating
presence
of
additional
driver
events
for
progression
to
an
irreversible,
highly
heterogeneous,
invasive
lesion.
Recently,
researchers
are
emphasizing
mechanisms
environmental
tumor
risk
factors
epigenetic
alterations
that
profoundly
influencing
early
malignant
evolution,
independently
inducing
mutations.
Additionally,
evolution
tumorigenesis
reflects
multifaceted
interplay
between
cell-intrinsic
identities
various
cell-extrinsic
exert
selective
pressures
either
restrain
uncontrolled
proliferation
or
allow
specific
clones
progress
tumors.
by
which
induce
both
intrinsic
cellular
competency
remodel
stress
facilitate
not
fully
understood.
In
this
review,
we
summarize
genetic,
epigenetic,
external
events,
effects
on
co-evolution
transformed
cells
ecosystem
during
initiation
evolution.
A
deeper
understanding
earliest
molecular
holds
promise
translational
applications,
predicting
individuals
at
high-risk
developing
strategies
intercept
transformation.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Дек. 13, 2023
Abstract
Metabolic
reprogramming
in
cancer
and
immune
cells
occurs
to
support
their
increasing
energy
needs
biological
tissues.
Here
we
propose
Single
Cell
Spatially
resolved
(scSpaMet)
framework
for
joint
protein-metabolite
profiling
of
single
male
human
tissues
by
incorporating
untargeted
spatial
metabolomics
targeted
multiplexed
protein
imaging
a
pipeline.
We
utilized
the
scSpaMet
profile
cell
types
metabolomic
maps
19507,
31156,
8215
lung
cancer,
tonsil,
endometrium
tissues,
respectively.
The
analysis
revealed
type-dependent
metabolite
profiles
local
competition
neighboring
Deep
learning-based
embedding
unique
states
within
types.
Trajectory
inference
showed
metabolic
patterns
along
differentiation
paths.
show
scSpaMet’s
ability
quantify
visualize
cell-type
specific
spatially
metabolic-protein
mapping
as
an
emerging
tool
systems-level
understanding
tissue
biology.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Март 27, 2024
Abstract
Hyperactivation
of
YAP/TAZ,
the
Hippo
pathway
downstream
effectors,
is
common
in
human
cancer.
The
requirement
YAP/TAZ
for
cancer
cell
survival
preclinical
models,
prompted
development
pharmacological
inhibitors
that
suppress
their
transcriptional
activity.
However,
systemic
inhibition
may
sometimes
have
unpredictable
patient
outcomes,
with
limited
or
even
adverse
effects
because
action
not
simply
tumor
promoting
but
also
suppressive
some
types.
Here,
we
review
role
distinct
populations,
discuss
impact
inhibiting
output
on
growth,
and
examine
current
developments
inhibitors.
Biomarker Research,
Год журнала:
2025,
Номер
13(1)
Опубликована: Янв. 23, 2025
The
tumor
microenvironment
functions
as
a
dynamic
and
intricate
ecosystem,
comprising
diverse
array
of
cellular
non-cellular
components
that
precisely
orchestrate
pivotal
behaviors,
including
invasion,
metastasis,
drug
resistance.
While
unraveling
the
interplay
between
behaviors
represents
tremendous
challenge,
recent
research
illuminates
crucial
biological
phenomenon
known
mechanotransduction.
Within
microenvironment,
mechanical
cues
like
tensile
stress,
shear
stiffness
play
role
by
activating
mechanosensitive
effectors
such
PIEZO
proteins,
integrins,
Yes-associated
protein.
This
activation
initiates
cascades
intrinsic
signaling
pathways,
effectively
linking
physical
properties
tissues
to
their
physiological
pathophysiological
processes
morphogenesis,
regeneration,
immunity.
mechanistic
insight
offers
novel
perspective
on
how
within
impact
behaviors.
intricacies
are
yet
be
fully
elucidated,
it
exhibits
distinct
attributes
from
non-malignant
tissues,
elevated
solid
stresses,
interstitial
hypertension,
augmented
matrix
stiffness,
enhanced
viscoelasticity.
These
traits
exert
notable
influences
progression
treatment
responses,
enriching
our
comprehension
multifaceted
nature
microenvironment.
Through
this
innovative
review,
we
aim
provide
new
lens
decipher
contexts,
broadening
knowledge
these
factors
promote
or
inhibit
thus
offering
valuable
insights
identify
potential
targets
for
anti-tumor
strategies.
Communications Biology,
Год журнала:
2023,
Номер
6(1)
Опубликована: Окт. 7, 2023
Lung
cancer,
a
major
contributor
to
cancer-related
fatalities
worldwide,
involves
complex
pathogenesis.
Cathepsins,
lysosomal
cysteine
proteases,
play
roles
in
various
physiological
and
pathological
processes,
including
tumorigenesis.
Observational
studies
have
suggested
an
association
between
cathepsins
lung
cancer.
However,
the
causal
link
cathepsin
family
cancer
remains
undetermined.
This
study
employed
Mendelian
randomization
analyses
investigate
this
association.
The
univariable
analysis
results
indicate
that
elevated
H
levels
increase
overall
risk
of
adenocarcinoma,
among
smokers.
Conversely,
reverse
suggest
squamous
carcinoma
may
lead
increased
B
levels.
A
multivariable
using
nine
as
covariates
reveals
In
conclusion,
serve
marker
for
potentially
inspiring
directions
diagnosis
treatment.
