Exosome-hybridized hydrogel acts as a foamy protective coat for the liver DOI

Y. Liang,

Shilun Li,

Yixiao Pan

и другие.

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 110841 - 110841

Опубликована: Янв. 1, 2025

Язык: Английский

Vasopressin drives aberrant myeloid differentiation of hematopoietic stem cells, contributing to depression in mice DOI

Rong Mou,

Junkai Ma,

Xuan Ju

и другие.

Cell stem cell, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

3
TERT prevents obesity-induced metabolic disorders by promoting adipose stem cell expansion and differentiation DOI Open Access
Laura Braud,

Manuel Bernabé,

Julien Vernerey

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 6, 2025

Abstract Obesity is linked to limited adipose tissue (AT) remodeling capacity, leading hypertrophic adipocytes, senescence, and inflammation. We used a mouse model expressing mTert (p21 +/Tert ) from the Cdkn1a locus investigate role of mTERT in obesity-induced metabolic disorders. Conditional expression reduces disorders associated with obesity. In AT, this accompanied by decrease number senescent p21-positive cells, very short telomeres, oxidative DNA damage. Single nucleus RNA-seq data reveal TERT attenuates senescence induced HFD particular stem progenitor cells (ASPC). show that ASPC expansion differentiation are promoted p21 obese mice, thereby reducing further report remodels landscape macrophages AT mice. Strikingly, inactivation catalytic activity +/TertCi mice suppresses promotion adipocyte formation, but neither affects attenuation nor macrophage remodeling. These results highlight mTERT’s canonical non-canonical functions obesity-associated thus appears as potential therapeutic option for

Язык: Английский

Процитировано

0
Histological Indicators of Aging at the Cellular Level: Cellular Senescence, Fibrosis, and Regenerative Capacity DOI Creative Commons

Eman Ali Elkordy

Journal of Microscopy and Ultrastructure, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Язык: Английский

Процитировано

0
Transcription factor networks in cellular quiescence DOI
Mithun Mitra, Sandra Batista, Hilary A. Coller

и другие.

Nature Cell Biology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Язык: Английский

Процитировано

0
Exosome-hybridized hydrogel acts as a foamy protective coat for the liver DOI

Y. Liang,

Shilun Li,

Yixiao Pan

и другие.

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 110841 - 110841

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0