Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 325 - 325
Опубликована: Фев. 26, 2025
The
emergence
of
nanotechnology
in
medicine,
particularly
using
iron
oxide
nanoparticles
(IONPs),
may
impact
cancer
treatment
strategies.
IONPs
exhibit
unique
properties,
such
as
superparamagnetism,
biocompatibility,
and
ease
surface
modification,
making
them
ideal
candidates
for
imaging,
therapeutic
interventions.
Their
application
targeted
drug
delivery,
especially
with
traditional
chemotherapeutic
agents
like
cisplatin,
has
shown
potential
overcoming
limitations
low
bioavailability
systemic
toxicity
chemotherapies.
Moreover,
IONPs,
by
releasing
ions,
can
induce
ferroptosis,
a
form
iron-dependent
cell
death,
which
offers
promising
pathway
to
reverse
radio-
chemoresistance
therapy.
In
particular,
demonstrate
significant
radiosensitisers,
enhancing
the
effects
radiotherapy
promoting
reactive
oxygen
species
(ROS)
generation,
lipid
peroxidation,
modulating
tumour
microenvironment
stimulate
antitumour
immune
responses.
This
review
explores
multifunctional
roles
radiosensitisation
through
ferroptosis
induction,
highlighting
their
promise
advancing
head
neck
cancers.
Additional
research
is
crucial
fully
addressing
clinical
settings,
offering
novel
approach
personalised
treatment.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Июль 1, 2024
The
applications
of
hydrogels
have
expanded
significantly
due
to
their
versatile,
highly
tunable
properties
and
breakthroughs
in
biomaterial
technologies.
In
this
review,
we
cover
the
major
achievements
potential
therapeutic
applications,
focusing
primarily
on
two
areas:
emerging
cell-based
therapies
promising
non-cell
modalities.
Within
context
cell
therapy,
discuss
capacity
overcome
existing
translational
challenges
faced
by
mainstream
therapy
paradigms,
provide
a
detailed
discussion
advantages
principal
design
considerations
for
boosting
efficacy
as
well
list
specific
examples
different
disease
scenarios.
We
then
explore
drug
delivery,
physical
intervention
therapies,
other
areas
(e.g.,
bioadhesives,
artificial
tissues,
biosensors),
emphasizing
utility
beyond
mere
delivery
vehicles.
Additionally,
complement
our
latest
progress
clinical
application
outline
future
research
directions,
particularly
terms
integration
with
advanced
biomanufacturing
This
review
aims
present
comprehensive
view
critical
insights
into
selection
both
tailored
meet
requirements
diverse
diseases
situations.
Cell Death and Disease,
Год журнала:
2024,
Номер
15(8)
Опубликована: Авг. 1, 2024
Abstract
Reactive
oxygen
species
(ROS)
are
highly
reactive
oxygen-containing
molecules
generated
as
natural
byproducts
during
cellular
processes,
including
metabolism.
Under
normal
conditions,
ROS
play
crucial
roles
in
diverse
functions,
cell
signaling
and
immune
responses.
However,
a
disturbance
the
balance
between
production
antioxidant
defenses
can
lead
to
an
excessive
buildup,
causing
oxidative
stress.
This
stress
damages
essential
components,
lipids,
proteins,
DNA,
potentially
culminating
death.
form
of
death
take
various
forms,
such
ferroptosis,
apoptosis,
necroptosis,
pyroptosis,
paraptosis,
parthanatos,
oxeiptosis,
each
displaying
distinct
genetic,
biochemical,
characteristics.
The
investigation
holds
promise
for
development
pharmacological
agents
that
used
prevent
tumorigenesis
or
treat
established
cancer.
Specifically,
targeting
key
SLC7A11,
GCLC,
GPX4,
TXN,
TXNRD,
represents
emerging
approach
inducing
cancer
cells.
review
provides
comprehensive
summary
recent
progress,
opportunities,
challenges
therapy.
Journal of Hematology & Oncology,
Год журнала:
2024,
Номер
17(1)
Опубликована: Июнь 6, 2024
Abstract
Ferroptosis,
an
iron-dependent
form
of
cell
death
characterized
by
uncontrolled
lipid
peroxidation,
is
governed
molecular
networks
involving
diverse
molecules
and
organelles.
Since
its
recognition
as
a
non-apoptotic
pathway
in
2012,
ferroptosis
has
emerged
crucial
mechanism
numerous
physiological
pathological
contexts,
leading
to
significant
therapeutic
advancements
across
wide
range
diseases.
This
review
summarizes
the
fundamental
mechanisms
regulatory
pathways
underlying
ferroptosis,
including
both
GPX4-dependent
-independent
antioxidant
mechanisms.
Additionally,
we
examine
involvement
various
conditions,
cancer,
neurodegenerative
diseases,
sepsis,
ischemia–reperfusion
injury,
autoimmune
disorders,
metabolic
disorders.
Specifically,
explore
role
response
chemotherapy,
radiotherapy,
immunotherapy,
nanotherapy,
targeted
therapy.
Furthermore,
discuss
pharmacological
strategies
for
modulating
potential
biomarkers
monitoring
this
process.
Lastly,
elucidate
interplay
between
other
forms
regulated
death.
Such
insights
hold
promise
advancing
our
understanding
context
human
health
disease.
Cell Death Discovery,
Год журнала:
2024,
Номер
10(1)
Опубликована: Апрель 29, 2024
Abstract
Receptor-interacting
protein
kinase
3
(RIPK3),
a
member
of
the
receptor-interacting
(RIPK)
family
with
serine/threonine
activity,
interacts
RIPK1
to
generate
necrosomes,
which
trigger
caspase-independent
programmed
necrosis.
As
vital
component
RIPK3
plays
an
indispensable
role
in
necroptosis,
is
crucial
for
human
life
and
health.
In
addition,
participates
pathological
process
several
infections,
aseptic
inflammatory
diseases,
tumors
(including
tumor-promoting
-suppressive
activities)
by
regulating
autophagy,
cell
proliferation,
metabolism
production
chemokines/cytokines.
This
review
summarizes
recent
research
progress
regulators
signaling
pathway
discusses
potential
RIPK3/necroptosis
aetiopathogenesis
various
diseases.
An
in-depth
understanding
mechanisms
functions
may
facilitate
development
novel
therapeutic
strategies.
Signal Transduction and Targeted Therapy,
Год журнала:
2025,
Номер
10(1)
Опубликована: Фев. 18, 2025
Abstract
Breast
cancer,
characterized
by
unique
epidemiological
patterns
and
significant
heterogeneity,
remains
one
of
the
leading
causes
malignancy-related
deaths
in
women.
The
increasingly
nuanced
molecular
subtypes
breast
cancer
have
enhanced
comprehension
precision
treatment
this
disease.
mechanisms
tumorigenesis
progression
been
central
to
scientific
research,
with
investigations
spanning
various
perspectives
such
as
tumor
stemness,
intra-tumoral
microbiota,
circadian
rhythms.
Technological
advancements,
particularly
those
integrated
artificial
intelligence,
significantly
improved
accuracy
detection
diagnosis.
emergence
novel
therapeutic
concepts
drugs
represents
a
paradigm
shift
towards
personalized
medicine.
Evidence
suggests
that
optimal
diagnosis
models
tailored
individual
patient
risk
expected
are
crucial,
supporting
era
oncology
for
cancer.
Despite
rapid
advancements
increasing
emphasis
on
clinical
comprehensive
update
summary
panoramic
knowledge
related
disease
needed.
In
review,
we
provide
thorough
overview
global
status
including
its
epidemiology,
factors,
pathophysiology,
subtyping.
Additionally,
elaborate
latest
research
into
contributing
progression,
emerging
strategies,
long-term
management.
This
review
offers
valuable
insights
Cancer
Research,
thereby
facilitating
future
progress
both
basic
application.
Chemical Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Ferroptosis,
an
iron-dependent
form
of
regulatory
cell
death,
has
garnered
significant
interest
as
a
therapeutic
target
in
cancer
treatment
due
to
its
distinct
characteristics,
including
lipid
peroxide
generation
and
redox
imbalance.
However,
clinical
application
oncology
is
currently
limited
by
issues
such
suboptimal
efficacy
potential
off-target
effects.
The
advent
nanotechnology
provided
new
way
for
overcoming
these
challenges
through
the
development
activatable
magnetic
nanoparticles
(MNPs).
These
innovative
MNPs
are
designed
improve
specificity
ferroptosis
induction.
This
Review
delves
into
chemical
biological
principles
guiding
design
ferroptosis-based
therapies
imaging-guided
therapies.
It
discusses
mechanisms
attributes
ferroptosis,
composition
MNPs,
their
mechanism
action
inducers,
integration
with
advanced
imaging
techniques
monitoring.
Additionally,
we
examine
convergence
other
strategies,
chemodynamic
therapy,
photothermal
photodynamic
sonodynamic
immunotherapy,
within
context
nanomedicine
strategies
utilizing
MNPs.
highlights
multifunctional
surpass
limitations
conventional
treatments,
envisioning
future
drug-resistance-free,
precision
diagnostics
treating
recalcitrant
cancers.
Redox Biology,
Год журнала:
2024,
Номер
75, С. 103259 - 103259
Опубликована: Июнь 27, 2024
Ferroptosis
is
a
form
of
iron-related
oxidative
cell
death
governed
by
an
integrated
redox
system,
encompassing
pro-oxidative
proteins
and
antioxidative
proteins.
These
undergo
precise
control
through
diverse
post-translational
modifications,
including
ubiquitination,
phosphorylation,
acetylation,
O-GlcNAcylation,
SUMOylation,
methylation,
N-myristoylation,
palmitoylation,
modification.
modifications
play
pivotal
roles
in
regulating
protein
stability,
activity,
localization,
interactions,
ultimately
influencing
both
the
buildup
iron
lipid
peroxidation.
In
mammalian
cells,
regulators
ferroptosis
typically
degradation
via
two
principal
pathways:
ubiquitin-proteasome
which
handles
majority
degradation,
autophagy,
primarily
targeting
long-lived
or
aggregated
This
comprehensive
review
aims
to
summarize
recent
advances
modification
linked
ferroptosis.
It
also
discusses
strategies
for
modulating
systems,
providing
new
insights
into
potential
therapeutic
applications
cancer
non-neoplastic
diseases.
