The establishment of the 3D genome structure during zygotic genome activation
Annals of the New York Academy of Sciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 3, 2025
Abstract
During
zygotic
genome
activation
(ZGA)
and
early
development,
hierarchical
levels
of
chromatin
structure
undergo
remarkable
perturbations:
changes
in
the
nuclear‐to‐cytoplasmic
ratio
various
components;
accessibility;
histone
exchange;
formation
3D
structures
such
as
loops,
topologically
associated
domains,
compartments.
Here,
we
review
peculiarities,
variability,
emergence
structural
features
during
ZGA
different
organisms.
Focusing
on
newly
found
called
fountains
,
describe
prerequisites
for
cohesin
loading
DNA
possible
mechanisms
organization
development.
Fountains
resulting
from
asymmetric
bidirectional
extrusion
spread
cohesin‐loading
points
a
CTCF‐independent
manner.
We
discuss
that
may
not
possess
specific
functions,
unlike
conventional
structures,
could
be
other
biological
processes
where
occurs.
Язык: Английский
Epigenome dynamics in early mammalian embryogenesis
Nature Reviews Genetics,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 3, 2025
Язык: Английский
Genome folding and zygotic genome activation in mammalian preimplantation embryos
Current Opinion in Genetics & Development,
Год журнала:
2024,
Номер
89, С. 102268 - 102268
Опубликована: Окт. 9, 2024
Язык: Английский
Current Status of Synthetic Mammalian Embryo Models
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12862 - 12862
Опубликована: Ноя. 29, 2024
Advances
in
three-dimensional
culture
technologies
have
facilitated
the
development
of
synthetic
embryo
models,
such
as
blastoids,
through
co-culturing
diverse
stem
cell
types.
These
vitro
models
enable
precise
investigation
developmental
processes,
including
gastrulation,
neurulation,
and
lineage
specification,
thereby
advancing
our
understanding
early
embryogenesis.
By
providing
controllable,
ethically
viable
platforms,
they
help
circumvent
limitations
vivo
mammalian
studies
contribute
to
developing
regenerative
medicine
strategies.
Nonetheless,
ethical
challenges,
particularly
regarding
human
applications,
persist.
Comparative
across
various
species—such
mice,
humans,
non-human
primates,
ungulates,
like
pigs
cattle—offer
crucial
insights
into
both
species-specific
conserved
mechanisms.
In
this
review,
we
outline
differences
embryonic
discuss
recent
advancements
models.
Specifically,
focus
on
latest
research
involving
cattle,
provide
a
comprehensive
overview
improvements
technology.
biology,
improve
model
efficiency,
guide
new
Язык: Английский