Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging
Cell,
Год журнала:
2024,
Номер
187(24), С. 7025 - 7044.e34
Опубликована: Ноя. 1, 2024
Язык: Английский
Protocols for the application of human embryonic stem cell-derived neurons for aging modeling and gene manipulation
STAR Protocols,
Год журнала:
2025,
Номер
6(1), С. 103633 - 103633
Опубликована: Фев. 10, 2025
Язык: Английский
Association between oxidative balance score and all-cause mortality in stroke survivors
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 4, 2025
Stroke
is
the
second
leading
cause
of
death
globally.
Oxidative
stress
plays
a
critical
role
in
development
stroke.
The
Balance
Score
(OBS)
tool
used
to
assess
combined
impact
diet
and
lifestyle
on
body's
antioxidant
capacity.
study
included
stroke
survivors
from
National
Health
Nutrition
Examination
Survey
(1999-2018),
with
total
1,781
participants
median
follow-up
duration
6.5
years,
during
which
786
(39.59%)
died.
relationship
between
OBS
all-cause
mortality
was
assessed
using
Cox
proportional
hazards
model.
results
indicated
that
individuals
higher
quartiles
had
lower
rates.
Specifically,
patients
fourth
quartile
41%
reduced
risk
compared
those
first
(HR
=
0.59,
95%
CI
0.42-0.84,
p
0.003).
Restricted
cubic
spline
analysis
revealed
linear
inverse
mortality.
Subgroup
further
demonstrated
association
persisted
across
various
population
subgroups.
Overall,
our
suggests
levels
can
reduce
provides
new
evidence
for
their
lifestyle.
Язык: Английский
Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De‐Repressing LINE1 Via Heterochromatin Erosion at Parturition
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
Aging
of
the
fetal
membranes
participates
in
labor
onset.
However,
underlying
mechanism
is
poorly
understood.
Here,
we
identify
that
classical
secretory
protein
S100
calcium-binding
A9
(S100A9),
upon
de-phosphorylation
at
Thr
113,
translocates
to
nuclei
amnion
fibroblasts
human
membranes,
where
S100A9
causes
heterochromatin
erosion
via
segregation
maintenance
proteins,
resulting
Long
Interspersed
Nuclear
Element-1
(LINE1)
de-repression
parturition.
Increased
LINE1
retrotransposition
further
activates
type
I
interferon
response
cGAS-STING
pathway,
thereby
leading
fibroblast
senescence
with
consequent
increased
secretion
components
associated
senescence-associated
phenotype.
Mouse
studies
show
intra-amniotic
injection
vector
specifically
expressing
nucleus
induces
preterm
birth
along
and
cellular
which
blocked
by
inhibition
reverse-transcription.
Together,
these
findings
highlight
nuclear-translocated
acts
as
a
disruptor
de-repress
subsequently
triggers
Язык: Английский
Loss of vitamin D receptor induces premature ovarian insufficiency through compromising the 7-dehydrocholesterol-dependent anti-aging effects
Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
13
Опубликована: Апрель 10, 2025
Vitamin
D
has
the
potential
to
therapeutically
affect
endocrine
parameters
of
premature
ovarian
insufficiency
(POI)
patients.
Previous
research
indicated
that
serum
vitamin
levels
tend
decline
with
age
and
in
individuals
POI.
However,
precise
impact
deficiency
on
female
fertility,
especially
their
function,
remains
unclear.
receptor
(VDR)
mice
provide
a
model
investigate
possible
effect
reproduction.
In
this
study,
we
observed
abnormal
follicular
development
Vdr
mice.
This
anomaly
is
associated
reduced
expression
anti-Mullerian
hormone
(AMH)
disrupted
aromatase
disrupts
secretion.
Moreover,
our
findings
indicate
disturbs
redox
balance,
resulting
oxidative
stress
ovary,
which
further
suppresses
granulosa
cell
function
accelerates
aging.
Mechanistically,
loss
inhibits
de
novo
cholesterol
synthesis
by
transcriptional
repression
Hmgcr
,
antioxidant
anti-aging
effects
intermediate
product
7-dehydrocholesterol
(7-DHC)
are
also
decreased.
Treatment
7-DHC
effectively
reduces
ROS
alleviates
aging
KGN
cells
deficient
.
conclusion,
results
show
impairs
follicle
maturation
secretion
accelerating
aging,
as
result
7-DHC.
Язык: Английский
The Quest for Eternal Youth: Hallmarks of Aging and Rejuvenating Therapeutic Strategies
Biomedicines,
Год журнала:
2024,
Номер
12(11), С. 2540 - 2540
Опубликована: Ноя. 7, 2024
The
impressive
achievements
made
in
the
last
century
extending
lifespan
have
led
to
a
significant
growth
rate
of
elderly
individuals
populations
across
world
and
an
exponential
increase
incidence
age-related
conditions
such
as
cardiovascular
diseases,
diabetes
mellitus
type
2,
neurodegenerative
diseases.
To
date,
geroscientists
identified
12
hallmarks
aging
(genomic
instability,
telomere
attrition,
epigenetic
alterations,
loss
proteostasis,
impaired
macroautophagy,
mitochondrial
dysfunction,
nutrient
sensing,
cellular
senescence,
stem
cell
exhaustion,
defective
intercellular
communication,
chronic
inflammation,
gut
dysbiosis),
intricately
linked
among
each
other,
which
can
be
targeted
with
senolytic
or
senomorphic
drugs,
well
more
aggressive
approaches
cell-based
therapies.
side
effects
seriously
limit
use
these
drugs.
However,
since
rejuvenation
is
dream
mankind,
future
research
expected
improve
tolerability
available
drugs
highlight
novel
strategies.
In
meantime,
medical
community,
healthcare
providers,
society
should
decide
when
start
treatments
how
tailor
them
individually.
Язык: Английский
Perspectives on biomarkers of reproductive aging for fertility and beyond
Nature Aging,
Год журнала:
2024,
Номер
4(12), С. 1697 - 1710
Опубликована: Дек. 13, 2024
Язык: Английский
Senolytic Vaccines from the Central and Peripheral Tolerance Perspective
Vaccines,
Год журнала:
2024,
Номер
12(12), С. 1389 - 1389
Опубликована: Дек. 10, 2024
Preventive
medicine
has
proven
its
long-term
effectiveness
and
economic
feasibility.
Over
the
last
century,
vaccination
saved
more
lives
than
any
other
medical
technology.
At
present,
preventative
measures
against
most
infectious
diseases
are
successfully
used
worldwide;
in
addition,
platforms
oncological
even
autoimmune
being
actively
developed.
same
time,
development
of
led
to
an
increase
both
life
expectancy
proportion
age-associated
diseases,
which
pose
a
heavy
socio-economic
burden.
In
this
context,
vaccine-based
approaches
for
prevention
or
treatment
age-related
opens
up
broad
prospects
extending
period
active
longevity
high
potential.
It
is
well
known
that
associated
with
accumulation
senescent
cells
various
organs
tissues.
been
demonstrated
elimination
such
leads
restoration
functions,
rejuvenation,
extension
experimental
animals.
However,
vaccines
complicated
by
their
antigenic
heterogeneity
lack
unique
marker.
body’s
own
cells,
may
be
reason
low
immunogenicity.
This
mini-review
discusses
mechanisms
central
peripheral
tolerance
influence
formation
anti-senescent
immune
response
responsible
age.
Язык: Английский