Astrocyte regulation of behavioral outputs: the versatile roles of calcium DOI Creative Commons
Gillian Imrie, Isabella Farhy-Tselnicker

Frontiers in Cellular Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Май 15, 2025

Behavior arises from coordinated brain-wide neural and glial networks, enabling organisms to perceive, interpret, respond stimuli. Astrocytes play an important role in shaping behavioral output, yet the underlying molecular mechanisms are not fully understood. intrinsic extrinsic cues with calcium (Ca 2+ ) fluctuations, which highly heterogeneous across spatio-temporal scales, contexts, brain regions. This heterogeneity allows astrocytes exert dynamic regulatory effects on neuronal function but has made it challenging understand precise pathways linking astrocytic Ca specific outcomes, functional relevance of these signals remains unclear. Here, we review recent literature uncovering roles for signaling a wide array behaviors, including cognitive, homeostatic, affective focusing its physiological roles, potential pathological implications. We specifically highlight how different types linked distinct outcomes discuss limitations unanswered questions that remain be addressed.

Язык: Английский

Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling DOI

Jianghui Chen,

Jing Xiang, Meiyu Zhou

и другие.

Cell Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1
Nutrition, Lifestyle, and Environmental Factors in Lung Homeostasis and Respiratory Health DOI Open Access
Athanasios Pouptsis, Rosa Zaragozá, Elena R. García–Trevijano

и другие.

Nutrients, Год журнала: 2025, Номер 17(6), С. 954 - 954

Опубликована: Март 9, 2025

The lungs play a vital role in maintaining homeostasis by facilitating gas exchange and serving as structural immune barrier. External factors, including nutrition, lifestyle, environmental exposures, profoundly influence normal lung function contribute to the development, progression, prognosis of various respiratory diseases. Deficiencies key micronutrients, such vitamins A, D, C, well omega-3 fatty acids, can impair integrity epithelial lining, compromising lungs’ defense mechanisms increasing susceptibility injury disease. Obesity physical inactivity further disrupt inducing changes chest wall promoting pro-inflammatory state. Environmental pollutants worsen oxidative damage activate inflammatory pathways. Addressing these modifiable factors through interventions dietary optimization, activity programs, strategies reduce exposure offers promising avenues for preserving preventing disease progression. This review examines molecular pathways which influences impact homeostasis.

Язык: Английский

Процитировано

0
Astrocyte regulation of behavioral outputs: the versatile roles of calcium DOI Creative Commons
Gillian Imrie, Isabella Farhy-Tselnicker

Frontiers in Cellular Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Май 15, 2025

Behavior arises from coordinated brain-wide neural and glial networks, enabling organisms to perceive, interpret, respond stimuli. Astrocytes play an important role in shaping behavioral output, yet the underlying molecular mechanisms are not fully understood. intrinsic extrinsic cues with calcium (Ca 2+ ) fluctuations, which highly heterogeneous across spatio-temporal scales, contexts, brain regions. This heterogeneity allows astrocytes exert dynamic regulatory effects on neuronal function but has made it challenging understand precise pathways linking astrocytic Ca specific outcomes, functional relevance of these signals remains unclear. Here, we review recent literature uncovering roles for signaling a wide array behaviors, including cognitive, homeostatic, affective focusing its physiological roles, potential pathological implications. We specifically highlight how different types linked distinct outcomes discuss limitations unanswered questions that remain be addressed.

Язык: Английский

Процитировано

0