Polymer-based responsive structural color materials

Progress in Materials Science, Год журнала: 2023, Номер 135, С. 101091 - 101091

Опубликована: Фев. 10, 2023

Язык: Английский

---

Design aspects and characterization of hydrogel-based bioinks for extrusion-based bioprinting

Bioprinting, Год журнала: 2023, Номер 32, С. e00274 - e00274

Опубликована: Апрель 15, 2023

3D-bioprinting has become a valid technique for tissue and organ regeneration, as the printing of living cells is allowed while hydrogel-based ink material provides them mechanical structural support. Self-healing shear-thinning hydrogel inks can be considered most promising materials extrusion-based bioprinting (EBB), because extruded due to decrease in viscosity under shear, self-healed after removing which ensures safe shape fidelity bioprinting. To achieve best final result, some technique, biological aspects need considered. In addition, versatile characterization pre- post-printing properties helps improve bioprinted constructs. However, despite great advances 3D-bioprinting, related challenges such opposing characteristics, lack controllable micro-environment, or technological increase speed print resolution must resolved. terms characterization, more standardization also needed. computational modeling would help performance construct. Thus, future going towards larger multifunctional tissue/organ constructs with multi-scale vascularization innervation. Multiple techniques are probably combined, but completely new Further, multimaterial enable heterogeneity gradients On other hand, using 4D-bioprinting, dynamic nature complex organs could added By combining microphysiological platforms (tissue- organ-on-a-chip systems) development functional tissues intended implantation go forward. The translation EBB into clinical practice still early stages, potential regenerative medicine challenges, biomimicry, reproducibility up-scaling issues have been overcome. this review, design property requirements ideal bioink, bioinks presented. Also, prospects discussed.

Язык: Английский

---

Bioinspired oral delivery devices

Nature Reviews Bioengineering, Год журнала: 2023, Номер 1(3), С. 208 - 225

Опубликована: Фев. 2, 2023

Oral administration is a widespread and convenient drug delivery approach. However, oral can be affected by the complex digestive tract environment, including irregular tissue morphology, presence of enzymes, mucus mucosal barriers, spatiotemporal variance in physiological parameters. These obstacles prevent many therapeutics. To overcome these challenges, devices designed with bioinspired compositions, structures or functions to make more drugs available for administration. Various have been developed harnessing biological materials living microorganisms, imitating functions. In this Review, we discuss design modification devices, examining engineering strategies target specific tissues applications. We highlight how key bottlenecks addressed through designs, concluding an outlook on remaining challenges towards clinical translation devices. commonly used strategy deliver harsh environment prevents negatively affect efficacy. This Review discusses microorganisms into that associated delivery.

Язык: Английский

---

Glucose metabolism-inspired catalytic patches for NIR-II phototherapy of diabetic wound infection

Acta Biomaterialia, Год журнала: 2022, Номер 157, С. 200 - 209

Опубликована: Дек. 7, 2022

Язык: Английский

---

Kidney-on-a-Chip: Mechanical Stimulation and Sensor Integration

Sensors, Год журнала: 2022, Номер 22(18), С. 6889 - 6889

Опубликована: Сен. 13, 2022

Bioengineered in vitro models of the kidney offer unprecedented opportunities to better mimic vivo microenvironment. Kidney-on-a-chip technology reproduces 2D or 3D features which can replicate tissue architecture, composition, and dynamic mechanical forces experienced by cells vivo. Kidney are exposed stimuli such as substrate stiffness, shear stress, compression, stretch, regulate multiple cellular functions. Incorporating kidney-on-a-chip is critically important for recapitulating physiological pathological This review will explore approaches applying different cell types using how these systems used study physiology, model disease, screen drug toxicity. We further discuss sensor integration into monitoring responses other stimuli. advantages, limitations, challenges associated with incorporating a variety applications. Overall, this aims highlight importance design implementation devices.

Язык: Английский

---

Small tissue chips with big opportunities for space medicine

Life Sciences in Space Research, Год журнала: 2022, Номер 35, С. 150 - 157

Опубликована: Сен. 8, 2022

Язык: Английский

---

In situ biosensing technologies for an organ-on-a-chip

Biofabrication, Год журнала: 2023, Номер 15(4), С. 042002 - 042002

Опубликована: Авг. 17, 2023

Abstract The in vitro simulation of organs resolves the accuracy, ethical, and cost challenges accompanying vivo experiments. Organoids organs-on-chips have been developed to model , real-time biological physiological features organs. Numerous studies deployed these systems assess responses an organ external stimuli. Particularly, can be most efficiently employed pharmaceutical drug development predict before approving such drugs. Furthermore, multi-organ-on-a-chip facilitate close representations environment. In this review, we discuss biosensing technology that facilitates situ measurements as readouts on organ-on-a-chip systems, including multi-organ models. Notably, a human-on-a-chip system integrated with automated multi-sensing will established by further advancing chips, well their assessment techniques.

Язык: Английский

---

Lymph Node-on-Chip Technology: Cutting-Edge Advances in Immune Microenvironment Simulation

Pharmaceutics, Год журнала: 2024, Номер 16(5), С. 666 - 666

Опубликована: Май 16, 2024

Organ-on-a-chip technology is attracting growing interest across various domains as a crucial platform for drug screening and testing set to play significant role in precision medicine research. Lymph nodes, being intricately structured organs essential the body’s adaptive immune responses antigens foreign particles, are pivotal assessing immunotoxicity of novel pharmaceuticals. Significant progress has been made research on structure function lymphatic system. However, there still an urgent need develop prospective tools techniques delve deeper into its diseases’ pathological physiological processes corresponding immunotherapeutic therapies. Organ chips can accurately reproduce specific functional areas lymph nodes better simulate complex microstructure interactions between different cells, which convenient studying biological processes. This paper reviews existing node their design approaches. It discusses applications above systems modeling cell motility, cell–cell interactions, vaccine responses, testing, cancer Finally, we summarize challenges that current faces terms structure, source, extracellular matrix simulation provide outlook future direction integrated system chips.

Язык: Английский

---

Co-axial printing of convoluted proximal tubule for kidney disease modeling

Biofabrication, Год журнала: 2022, Номер 14(4), С. 044102 - 044102

Опубликована: Июнь 14, 2022

Abstract Despite the increasing incidence of kidney-related diseases, we are still far from understanding underlying mechanisms these diseases and their progression. This lack is partly because a poor replication in vitro, limited to planar culture. Advancing towards three-dimensional models, hereby propose coaxial printing obtain microfibers containing helical hollow microchannel. These recapitulate architecture proximal tubule (PT), an important nephron segment often affected kidney disorders. A stable gelatin/alginate-based ink was formulated allow printability while maintaining structural properties. Fine-tuning composition, temperature extrusion rate allowed for optimal viscosity that led coiling microfiber’s inner channel. The printed exhibited prolonged stability (42 days) cytocompatibility Healthy conditionally immortalized PT epithelial cells knockout cell model cystinosis ( CTNS -/- ) were seeded mimic two genotypes PT. Upon culturing 14 days, engineered showed homogenous cytoskeleton organization as indicated by staining filamentous actin, barrier-formation polarization with apical marker α -tubulin basolateral Na + /K -ATPase. Cell viability slightly decreased upon which more pronounced microfibers. Finally, reduced transport activity compared healthy when looking at breast cancer resistance protein multidrug resistance-associated 4. Engineered incorporated custom-designed microfluidic chip assess leak-tightness epithelium, appeared less tight PT, agreement its vivo phenotype. While on verge patient-oriented medicine, this system holds great promise further research establishing advanced vitro disease models.

Язык: Английский

---

Integrative lymph node-mimicking models created with biomaterials and computational tools to study the immune system

Materials Today Bio, Год журнала: 2022, Номер 14, С. 100269 - 100269

Опубликована: Март 1, 2022

The lymph node (LN) is a vital organ of the lymphatic and immune system that enables timely detection, response, clearance harmful substances from body. Each LN comprises distinct substructures, which host plethora cell types working in tandem to coordinate complex innate adaptive responses. An improved understanding biology could facilitate treatment LN-associated pathologies immunotherapeutic interventions, yet at present, animal models, often have poor physiological relevance, are most popular experimental platforms. Emerging biomaterial engineering offers powerful alternatives, with potential circumvent limitations for in-depth characterization system. In addition, mathematical computational approaches, particularly current age big data research, reliable tools verify complement works. this review, we first discuss importance immunity protection followed by recent advances using biomaterials create vitro/vivo LN-mimicking models recreate lymphoid tissue microstructure microenvironment, as well describe related immuno-functionality biological investigation. We also explore great serve silico supports. Furthermore, suggest how both approaches can be integrated strengthen basic patho-biological translational drug screening clinical personalized therapies. hope review will promote synergistic collaborations accelerate progress systems enhance immuno-complexity.

Язык: Английский

---