Systematic evaluation of fMRI data-processing pipelines for consistent functional connectomics

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июнь 4, 2024

Abstract Functional interactions between brain regions can be viewed as a network, enabling neuroscientists to investigate function through network science. Here, we systematically evaluate 768 data-processing pipelines for reconstruction from resting-state functional MRI, evaluating the effect of parcellation, connectivity definition, and global signal regression. Our criteria seek that minimise motion confounds spurious test-retest discrepancies topology, while being sensitive both inter-subject differences experimental effects interest. We reveal vast systematic variability across pipelines’ suitability connectomics. Inappropriate choice pipeline produce results are not only misleading, but so, with majority failing at least one criterion. However, set optimal consistently satisfy all different datasets, spanning minutes, weeks, months. provide full breakdown each pipeline’s performance inform future best practices in

Язык: Английский

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Targeting mitophagy in neurodegenerative diseases

Nature Reviews Drug Discovery, Год журнала: 2025, Номер unknown

Опубликована: Янв. 14, 2025

Язык: Английский

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Engineering brain-on-a-chip platforms

Nature Reviews Bioengineering, Год журнала: 2024, Номер 2(8), С. 691 - 709

Опубликована: Июнь 5, 2024

Язык: Английский

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Acetyl-DL-leucine in two individuals with REM sleep behavior disorder improves symptoms, reverses loss of striatal dopamine-transporter binding and stabilizes pathological metabolic brain pattern—case reports

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Сен. 2, 2024

Abstract Isolated REM Sleep Behavior Disorder (iRBD) is considered a prodrome of Parkinson’s disease (PD). We investigate whether the potentially disease-modifying compound acetyl- DL -leucine (ADLL; 5 g/d) has an effect on prodromal PD progression in 2 iRBD-patients. Outcome parameters are RBD-severity sum-score (RBD-SS-3), dopamine-transporter single-photon emission computerized tomography (DAT-SPECT) and metabolic “Parkinson-Disease-related-Pattern (PDRP)”-z-score 18 F-fluorodeoxyglucose positron (FDG-PET). After 3 weeks ADLL-treatment, RBD-SS-3 drops markedly both patients remains reduced for >18 months ADLL-treatment. In patient 1 (female), DAT-SPECT putaminal binding ratio (PBR) decreases years pretreatment from normal (1.88) to pathological (1.22) patient’s FDG-PET-PDRP-z-score rises 1.72 3.28 (pathological). 22 DAT-SPECT-PBR increases 1.67 stabilizes at 3.18. Similar results seen (male): his value 1.42 (close normal) 1.02 0.30 after These support exploration ADLL may have properties PD.

Язык: Английский

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Functional connectome through the human life span

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Сен. 13, 2023

The lifespan growth of the functional connectome remains unknown. Here, we assemble task-free and structural magnetic resonance imaging data from 33,250 individuals aged 32 postmenstrual weeks to 80 years 132 global sites. We report critical inflection points in nonlinear curves mean variance connectome, peaking late fourth third decades life, respectively. After constructing a fine-grained, lifespan-wide suite system-level brain atlases, show distinct maturation timelines for segregation within different systems. Lifespan regional connectivity is organized along primary-to-association cortical axis. These connectome-based normative models reveal substantial individual heterogeneities networks patients with autism spectrum disorder, major depressive Alzheimer's disease. findings elucidate evolution can serve as reference quantifying variation development, aging, neuropsychiatric disorders.

Язык: Английский

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Toward interpretability of machine learning methods for the classification of patients with major depressive disorder based on functional network measures

Chaos An Interdisciplinary Journal of Nonlinear Science, Год журнала: 2023, Номер 33(6)

Опубликована: Июнь 1, 2023

We address the interpretability of machine learning algorithm in context relevant problem discriminating between patients with major depressive disorder (MDD) and healthy controls using functional networks derived from resting-state magnetic resonance imaging data. applied linear discriminant analysis (LDA) to data 35 MDD 50 discriminate two groups utilizing networks' global measures as features. proposed combined approach for feature selection based on statistical methods wrapper-type algorithm. This revealed that are indistinguishable univariate space but become distinguishable a three-dimensional formed by identified most important features: mean node strength, clustering coefficient, number edges. LDA achieves highest accuracy when considering network all connections or only strongest ones. Our allowed us analyze separability classes multidimensional space, which is critical interpreting results models. demonstrated parametric planes control rotate increasing thresholding parameter their intersection increases approaching threshold 0.45, classification minimal. Overall, provides an effective interpretable scenario connectivity networks. can be other tasks achieve high while ensuring results.

Язык: Английский

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Positive relation between dopamine neuron degeneration and metabolic connectivity disruption in the MPTP plus probenecid mouse model of Parkinson's disease

Experimental Neurology, Год журнала: 2024, Номер 374, С. 114704 - 114704

Опубликована: Янв. 26, 2024

The clinical manifestation of Parkinson's disease (PD) appears when neurodegeneration is already advanced, compromising the efficacy disease-modifying treatment approaches. Biomarkers to identify early stages PD are therefore paramount importance for advancement therapy PD. In present study, by using a mouse model obtained subchronic with neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and clearance inhibitor probenecid (MPTPp), we identified prodromal markers combining in vivo positron emission tomography (PET) imaging ex immunohistochemistry. Longitudinal PET dopamine transporter (DAT) [18F]-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane ([18F]-FP-CIT), brain glucose metabolism 2-deoxy-2-[18F]-fluoroglucose ([18F]-FDG) were performed before MPTPp after 1, 3, 10 administrations, order assess relation between neuron integrity connectivity. results show that [18F]-FP-CIT dorsal striatum was not modified first administration MPTPp, tended decrease 3 significantly decreased administrations. Post-mortem immunohistochemical analyses DAT tyrosine hydroxylase (TH) showed positive correlation [18F]-FP-CIT, confirming validity repeated MPTPp-treated mice as can reproduce progressive pathological changes phases Analysis [18F]-FDG uptake several areas connected metabolic connectivity progressively disrupted, starting from administration, significant connections cortical subcortical regions lost suggesting an association degeneration disruption this model. study provide relevant model, where new drugs alleviate could be evaluated preclinically.

Язык: Английский

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Structure–function coupling reveals the brain hierarchical structure dysfunction in Alzheimer's disease: A multicenter study

Alzheimer s & Dementia, Год журнала: 2024, Номер 20(9), С. 6305 - 6315

Опубликована: Июль 28, 2024

Abstract BACKGROUND Alzheimer's disease (AD) is a neurodegenerative condition characterized by cognitive decline. To date, the specific dysfunction in brain's hierarchical structure AD remains unclear. METHODS We introduced structural decoupling index (SDI), based on multi‐site data set comprising functional and diffusion‐weighted magnetic resonance imaging from 793 subjects, to assess their brain hierarchy. RESULTS Compared normal controls (NCs), individuals with exhibited increased SDI within posterior superior temporal sulcus, insular gyrus, precuneus, hippocampus, amygdala, postcentral cingulate gyrus; meanwhile, patients demonstrated decreased frontal lobe. The those regions also showed significant correlation ability. Moreover, was robust neuroimaging biomarker capable of accurately distinguishing diagnostic status (area under curve [AUC] = 0.86). DISCUSSION Our findings revealed AD. Furthermore, could serve as promising for Highlights This study utilized multi‐center, multi‐modal East Asian populations. found an spatial gradient (SDI) sensory–motor higher‐order regions. Changes are associated energy metabolism mitochondria. can identify further uncover mechanisms

Язык: Английский

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Development of a non-invasive novel individual marmoset holder for evaluation by awake functional magnetic resonance brain imaging

Journal of Neuroscience Methods, Год журнала: 2025, Номер unknown, С. 110390 - 110390

Опубликована: Фев. 1, 2025

Язык: Английский

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Reduced Modulation of Theta and Beta Oscillations Mediates Empathy Impairment in Parkinson's Disease

Brain and Behavior, Год журнала: 2025, Номер 15(2)

Опубликована: Фев. 1, 2025

ABSTRACT Background Empathy is an inaccessible part of advanced social cognitive functions in humans. Impairment empathy greatly affects the quality life patients with Parkinson's disease (PD) but underlying neurophysiologic mechanisms have not been established. Objectives The dynamic process brain oscillations PD pain was explored and mechanism damage studied. Methods A total 27 13 healthy controls were recruited to undergo a judgment task, event‐related potentials recorded. This study compared changes theta beta among two groups after presentation painful neutral stimuli. Results Time–frequency analysis results revealed that exhibited oscillation synchronization desynchronization during empathy. Compared controls, reduced magnitude response stimuli attenuated induced by There are abnormal power differences between stimuli, while no found PD. Moreover, positive correlation existed degree associated accuracy judgments. Conclusion Pain deficits modulation oscillations.

Язык: Английский

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