Achieving tissue-level softness on stretchable electronics through a generalizable soft interlayer design

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Июль 26, 2023

Abstract Soft and stretchable electronics have emerged as highly promising tools for biomedical diagnosis biological studies, they interface intimately with the human body other systems. Most electronic materials devices, however, still Young’s moduli orders of magnitude higher than soft bio-tissues, which limit their conformability long-term biocompatibility. Here, we present a design strategy interlayer allowing use existing relatively high to versatilely realize devices ultralow tissue-level moduli. We demonstrated transistor arrays active-matrix circuits below 10 kPa—over two lower current state art. Benefiting from increased irregular dynamic surfaces, ultrasoft device created realizes electrophysiological recording on an isolated heart adaptability, spatial stability, minimal influence ventricle pressure. In vivo biocompatibility tests also demonstrate benefit suppressing foreign-body responses implantation. With its general applicability diverse this soft-interlayer overcomes material-level limitation imparting softness variety bioelectronic devices.

Язык: Английский

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High-density single-unit human cortical recordings using the Neuropixels probe

Neuron, Год журнала: 2022, Номер 110(15), С. 2409 - 2421.e3

Опубликована: Июнь 8, 2022

Язык: Английский

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Insights into Hierarchical Structure–Property–Application Relationships of Advanced Bacterial Cellulose Materials

Advanced Functional Materials, Год журнала: 2023, Номер 33(12)

Опубликована: Янв. 19, 2023

Abstract Bacterial cellulose (BC) is an environmentally friendly biomaterial that widely investigated because it possesses a unique hierarchical nanofiber network structure as well extraordinary performance. In this review, the formation of BC from perspective biosynthesis illustrated based on its basic chemical and crystal structure. Moreover, design processing BC‐based advanced materials through biosynthesis, physical, and/or modification are also reviewed. The intrinsic characteristics BC, derived structure, analyzed to understand structure–property–application relationships. applications reviewed, such high‐strength structural utilizing properties nanofibers, energy conversion storage, bioelectronic interfaces, environmental remediation, thermal management ion transport 3D structures these materials. addition, authors offer their opinions potential future research directions for sustainably developing

Язык: Английский

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Planning in the brain

Neuron, Год журнала: 2022, Номер 110(6), С. 914 - 934

Опубликована: Янв. 17, 2022

Recent breakthroughs in artificial intelligence (AI) have enabled machines to plan tasks previously thought be uniquely human. Meanwhile, the planning algorithms implemented by brain itself remain largely unknown. Here, we review neural and behavioral data sequential decision-making that elucidate ways which does—and does not—plan. To systematically available biological data, create a taxonomy of summarizing relevant design choices for such AI. Across species, recording techniques, task paradigms, find converging evidence represents future states consistent with class within our taxonomy—focused, depth-limited, serial. However, argue current are insufficient addressing more detailed algorithmic questions. We propose new approach leveraging AI advances drive experiments can adjudicate between competing candidate algorithms.

Язык: Английский

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Translational opportunities and challenges of invasive electrodes for neural interfaces

Nature Biomedical Engineering, Год журнала: 2023, Номер 7(4), С. 424 - 442

Опубликована: Апрель 20, 2023

Язык: Английский

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