Neurobiology of Disease, Год журнала: 2022, Номер 175, С. 105918 - 105918
Опубликована: Ноя. 12, 2022
Язык: Английский
Neuroscience & Biobehavioral Reviews, Год журнала: 2020, Номер 120, С. 222 - 235
Опубликована: Ноя. 24, 2020
The ability to adapt dynamic environments requires tracking multiple signals with variable sensory salience and fluctuating behavioral relevance. This complex process integrative crosstalk between cognitive brain circuits. Functional interactions cortical thalamic regions are now considered essential for both perception cognition but a clear account of the functional link circuits is currently lacking. review aims document how nuclei may effectively act as bridge allowing fuse perceptual events into meaningful experiences. After highlighting key aspects thalamocortical such classic first-order/higher-order dichotomy, we consider role reticular nucleus from directed attention cognition. We next summarize research relying on Pavlovian learning paradigms, showing that first-order higher-order contribute associative learning. Finally, propose modulator inputs reaching all be critical purposes when environmental computed. Altogether, thalamus appears linking perception, possibly affect.
Язык: Английский
Процитировано
80
Communications Biology, Год журнала: 2021, Номер 4(1)
Опубликована: Сен. 6, 2021
Abstract Low-level states of consciousness are characterized by disruptions brain activity that sustain arousal and awareness. Yet, how structural, dynamical, local network properties interplay in the different levels is unknown. Here, we study fMRI dynamics from patients suffered injuries leading to a disorder healthy subjects undergoing propofol-induced sedation. We show pathological pharmacological low-level display less recurrent, connected more segregated synchronization patterns than conscious state. use whole-brain models built upon injured structural connectivity interpret these dynamical effects. found were associated with reduced interactions, together homogeneous structurally constrained dynamics. Notably, changes lead hub regions lose their stability during consciousness, thus attenuating differences between hubs non-hubs
Язык: Английский
Процитировано
79
Brain, Год журнала: 2019, Номер 142(12), С. 3991 - 4002
Опубликована: Окт. 8, 2019
See Vértes and Seidlitz (doi:10.1093/brain/awz353) for a scientific commentary on this article. Is schizophrenia by-product of human brain evolution? By comparing the chimpanzee connectomes, van den Heuvel et al. demonstrate that connections unique to show greater involvement in pathology. Modifications service higher-order functions may have rendered more vulnerable dysfunction.
Язык: Английский
Процитировано
78
Neuropsychopharmacology, Год журнала: 2021, Номер 47(1), С. 20 - 40
Опубликована: Сен. 28, 2021
Abstract The fundamental importance of prefrontal cortical connectivity to information processing and, therefore, disorders cognition, emotion, and behavior has been recognized for decades. Anatomic tracing studies in animals have formed the basis delineating direct monosynaptic connectivity, from cells origin, through axon trajectories, synaptic terminals. Advances neuroimaging combined with network science taken lead developing complex wiring diagrams or connectomes human brain. A key question is how well these magnetic resonance imaging (MRI)-derived networks hubs reflect anatomic “hard wiring” first proposed underlie distribution large-scale interactions. In this review, we address challenge by focusing on what known about connections non-human primates compares MRI-derived measurements organization humans. First, outline pathways each cortex (PFC) region. We then review available MRI-based techniques indirectly measuring structural functional introduce graph theoretical methods analysis hubs, modules, topologically integrative features connectome. Finally, bring two approaches together, using specific examples, demonstrate connections, demonstrated tract-tracing studies, can directly inform understanding composition PFC nodes edges that connect subcortical areas.
Язык: Английский
Процитировано
76
Neurobiology of Disease, Год журнала: 2022, Номер 175, С. 105918 - 105918
Опубликована: Ноя. 12, 2022
Язык: Английский
Процитировано
66