Frontiers in Computational Neuroscience,
Год журнала:
2024,
Номер
17
Опубликована: Янв. 18, 2024
We
study
how
stimulus
information
can
be
represented
in
the
dynamical
signatures
of
an
oscillatory
model
neural
activity—a
whose
activity
modulated
by
input
akin
to
signals
involved
working
memory
(WM).
developed
a
field
model,
tuned
near
instability,
which
WM-like
modulate
frequency
and
amplitude
oscillation.
Our
has
spatial-like
domain
that
preferentially
targets
point—a
feature—on
will
induce
feature-specific
changes.
These
changes
affect
both
mean
rate
spikes
relative
timing
spiking
global
oscillation—the
phase
activity.
From
these
two
signatures,
we
define
spike
code
code.
assess
performance
codes
discriminate
features
using
information-theoretic
analysis.
show
WM
modulations
enhance
discrimination
while
simultaneously
reducing
discrimination.
Moreover,
find
is
roughly
orders
magnitude
larger
than
defined
for
same
solutions.
The
results
our
have
applications
sensory
areas
brain,
prefrontal
send
inputs
reflecting
content
WM.
been
established
similar
model.
suggest
mechanism
may
beyond
comparatively
weak
representations
based
on
Journal of Neuroscience,
Год журнала:
2022,
Номер
42(38), С. 7201 - 7212
Опубликована: Авг. 22, 2022
Deficits
in
auditory
nerve
(AN)
function
for
older
adults
reduce
afferent
input
to
the
cortex.
The
extent
which
cortex
adapts
this
loss
of
and
mechanisms
underlying
adaptation
are
not
well
understood.
We
took
a
neural
systems
approach
measuring
AN
cortical
evoked
responses
within
50
27
younger
human
(59
female)
estimate
central
gain
or
increased
activity
despite
reduced
activity.
Relative
adults,
adults9
response
amplitudes
were
smaller,
but
not.
used
relationship
between
predict
from
their
responses.
Central
was
thus
defined
as
difference
observed
those
predicted
parameter
estimates
adults.
In
decreased
contributed
lower
GABA
levels,
greater
gain,
poorer
speech
recognition
noise
(SIN).
These
effects
on
SIN
occur
addition
to,
independent
from,
attributed
elevated
hearing
thresholds.
Our
results
consistent
with
animal
models
suggest
that
some
may
result
changes
encoding
inhibitory
neurotransmission,
contribute
SIN.
An
advancement
our
understanding
throughout
system
gradual
increasing
age
provide
potential
therapeutic
targets
intervention.
SIGNIFICANCE
STATEMENT
Age-related
is
one
most
common
chronic
conditions
aging,
yet
little
known
about
how
sensory
input.
measured
same
stimulus
we
found
hyperexcitability
relative
concomitant
declines
gain.
Lower
levels
GABA,
an
neurotransmitter,
associated
adapt
attenuated
by
reducing
inhibition
amplify
response,
amplification
lead
Cell Reports,
Год журнала:
2022,
Номер
38(13), С. 110568 - 110568
Опубликована: Март 1, 2022
GABAergic
signaling
provides
inhibitory
stabilization
and
spatiotemporally
coordinates
the
firing
of
recurrently
connected
excitatory
neurons
in
mature
cortical
circuits.
Inhibition
thus
enables
self-generated
neuronal
activity
patterns
that
underlie
various
aspects
sensation
cognition.
In
this
review,
we
aim
to
provide
a
conceptual
framework
describing
how
when
GABA-releasing
interneurons
acquire
their
network
functions
during
development.
Focusing
on
developing
visual
neocortex
hippocampus
mice
rats
vivo,
hypothesize
at
onset
patterned
activity,
glutamatergic
are
stable
by
themselves
is
not
yet
functional.
We
review
important
milestones
development
illustrate
cell-type-specific
strengthening
synaptic
inhibition
toward
eye
opening
shapes
dynamics
allows
cortex
progressively
disengage
from
extra-cortical
drive.
translate
human
discuss
clinical
implications
for
treatment
neonatal
seizures.
Cell Reports,
Год журнала:
2023,
Номер
42(9), С. 113088 - 113088
Опубликована: Сен. 1, 2023
Cortical
circuit
function
is
regulated
by
extensively
interconnected,
diverse
populations
of
GABAergic
interneurons
that
may
play
key
roles
in
shaping
operation
according
to
behavioral
context.
A
specialized
population
co-express
vasoactive
intestinal
peptides
(VIP-INs)
are
activated
during
arousal
and
innervate
other
INs
pyramidal
neurons
(PNs).
Although
state-dependent
modulation
VIP-INs
has
been
studied,
their
role
regulating
sensory
processing
less
well
understood.
We
examined
the
impact
primary
visual
cortex
awake
behaving
mice.
Loss
VIP-IN
activity
alters
somatostatin-expressing
(SST-INs)
but
not
PNs.
In
contrast,
reduced
globally
disrupts
feature
selectivity
for
stimulus
size.
Moreover,
on
perceptual
behavior
varies
with
context
more
acute
small
than
large
cues.
thus
contribute
both
cortical
context-dependent
performance.
Frontiers in Computational Neuroscience,
Год журнала:
2024,
Номер
17
Опубликована: Янв. 18, 2024
We
study
how
stimulus
information
can
be
represented
in
the
dynamical
signatures
of
an
oscillatory
model
neural
activity—a
whose
activity
modulated
by
input
akin
to
signals
involved
working
memory
(WM).
developed
a
field
model,
tuned
near
instability,
which
WM-like
modulate
frequency
and
amplitude
oscillation.
Our
has
spatial-like
domain
that
preferentially
targets
point—a
feature—on
will
induce
feature-specific
changes.
These
changes
affect
both
mean
rate
spikes
relative
timing
spiking
global
oscillation—the
phase
activity.
From
these
two
signatures,
we
define
spike
code
code.
assess
performance
codes
discriminate
features
using
information-theoretic
analysis.
show
WM
modulations
enhance
discrimination
while
simultaneously
reducing
discrimination.
Moreover,
find
is
roughly
orders
magnitude
larger
than
defined
for
same
solutions.
The
results
our
have
applications
sensory
areas
brain,
prefrontal
send
inputs
reflecting
content
WM.
been
established
similar
model.
suggest
mechanism
may
beyond
comparatively
weak
representations
based
on
