Alpha-2 receptor mediates the endogenous antagonistic regulation of itch and pain via descending noradrenaline pathway from the locus coeruleus

Brain Research Bulletin, Год журнала: 2025, Номер unknown, С. 111270 - 111270

Опубликована: Фев. 1, 2025

Язык: Английский

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Royal Jelly Enhances the Social Status of Submissive Rats by Restoring Balance to the Disturbed Gut–Brain Communication

Foods, Год журнала: 2025, Номер 14(5), С. 819 - 819

Опубликована: Фев. 27, 2025

Royal jelly (RJ) has long been considered a crucial dietary component in dictating caste differentiation honeybees. As nutritional additive, royal imparts broad range of benefits to mammals and humans; however, its precise impact on the social hierarchy these advanced animals is not yet fully understood. This study aims determine whether can be transferred rats alter their ranks uncover underlying mechanisms. A submissive model was established by inducing dysbiosis rats, via persistent exposure vancomycin. at dose 2.5 g/kg daily administered subject during postnatal weeks (PNW) 6 7. At end intervention, were subjected agonistic, water tube competition tests, order assess dominance status. revealed results, RJ treatment significantly improved rank dysbiotic demonstrating that elicit positive effect behaviors (caused dysbiosis) rats. All behavioral paradigms yielded consistent with no notable differences body weight or anxiety levels. Regarding gut microbiome, vancomycin caused which partially reversed jelly. Specifically, intestinal presence Proteobacteria profoundly attenuated supplementation, resulting comparable level intact/dominant genus level, both Escherichia Clostridium displayed similar dynamics relation Proteobacteria, implying involvement RJ-mediated switching. Transcriptomic analysis medial prefrontal context showed expression genes influenced intake, embodying various pathways related neuronal transmission such as neuroactive ligan-receptor interaction, synaptic vesicle cycle, etc. By virtue correlation analysis, Escherichia, Akkermansia strongly associated set gene modules around gastrin releasing peptide (Grp) signaling Rps6ka3, establishing an intrinsic gut-brain communication. Furthermore, infection trials degraded RJ-remedied while series cerebral like Grpr Grpel1, well spine density, concordantly altered, underscoring critical role link deciding outcomes dyadic contests. In summary, this intriguing example how influence mammals, emphasizing importance microbe-host interaction mediating species-spanning function shaping hierarchy.

Язык: Английский

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Deciphering Pain and Pruritus in Keloids from the Perspective of Neurological Dysfunction: Where Are We Now?

Biomedicines, Год журнала: 2025, Номер 13(3), С. 663 - 663

Опубликована: Март 8, 2025

Keloids are a typical skin fibroproliferative disease that can cause severe aesthetic and functional concerns. Pain pruritus the most common clinical symptoms of keloids, but mechanisms underlying these remain unclear. The peripheral nervous system plays pivotal role in transmission superficial sensation signals. Mounting evidence has shown potential correlations between disturbance pain keloids. Here, we summarize neurological dysfunction development pruritus, with specific focus on neuroanatomical alterations, sensory nerves, neurogenic inflammation.

Язык: Английский

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Astrocytic LCN2 drives uremic pruritus and morphine-induced pruritus via the GRP/GRPR pathway

Clinical and Experimental Nephrology, Год журнала: 2025, Номер unknown

Опубликована: Май 18, 2025

Язык: Английский

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The impact of cellular infiltration on pruritus in chronic spontaneous urticaria and the updated treatments: A narrative review

Dermatologica Sinica, Год журнала: 2025, Номер unknown

Опубликована: Май 20, 2025

Язык: Английский

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