Best Practice & Research Clinical Rheumatology, Год журнала: 2025, Номер unknown, С. 102055 - 102055
Опубликована: Март 1, 2025
Язык: Английский
Clinical Rheumatology, Год журнала: 2024, Номер 43(6), С. 1865 - 1870
Опубликована: Апрель 26, 2024
Язык: Английский
Процитировано
6
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 170, С. 116006 - 116006
Опубликована: Дек. 12, 2023
Rheumatoid arthritis (RA) is a chronic inflammatory condition known for its irreversible destructive impact on the joints. Chondrocytes play pivotal role in production and maintenance of cartilage matrix. However, presence cytokines can hinder chondrocyte proliferation promote apoptosis. Isoliquiritigenin (ISL), flavonoid, potentially exerts protective effects against various diseases. specific regulating nuclear factor E2-associated 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway chondrocytes RA remains unclear. To investigate this, this study used human Sprague-Dawley rats to construct vitro vivo models, respectively. The findings reveal that markedly induced oxidative stress, activation matrix metalloproteinases, apoptosis both vivo. Notably, ISL treatment significantly mitigated these effects. Moreover, Nrf2 or HO-1 inhibitors reversed ISL, attenuated expression Nrf2/HO-1 peroxisome proliferator-activated receptor gamma-coactivator-1α, promoted This finding indicates primarily targets chondrocytes. led improved behavior scores, reduced paw thickness, joint damage as well ameliorated stress skeletal muscles an rat model. In conclusion, highlights demonstrates potential option RA.
Язык: Английский
Процитировано
12
Scandinavian Journal of Rheumatology, Год журнала: 2024, Номер 53(3), С. 161 - 172
Опубликована: Фев. 15, 2024
Objectives Our aim was to conduct a population-based projection estimate the number of rheumatoid arthritis (RA) cases in Germany until 2040.
Язык: Английский
Процитировано
4
Frontiers in Medicine, Год журнала: 2024, Номер 11
Опубликована: Окт. 23, 2024
Objective To systematically evaluate the global burden and trends of low back pain(LBP) associated with high Body Mass Index (BMI) project future up to 2050 using Bayesian Age-Period-Cohort (BAPC) model, providing scientific evidence for prioritizing preventive actions. Methods Utilizing data from Global Burden Disease (GBD) 2021 study, this research analyzes disease pain linked BMI globally, Disability-Adjusted Life Years (DALYs) as primary metric. We examined by gender, age, exposure rate Estimated Annual Percentage Change (EAPC) projected BAPC model. Results In 2021, BMI-related accounted 8,363,759 DALYs, an age-standardized 97.66 per 100,000 population EAPC 1.14. The DALYs varied significantly country, United States, Australia, Eastern Europe experiencing highest rates, all exceeding 225 population. has increased notable rises in China, Southeast Asia, South Africa, where EAPCs surpassed 2.5. Regions medium Socio-Demographic (SDI) showed most substantial increases, DALY SDI areas rising 118.84 161.80 100,000, 41.92 79.10 100,000. Throughout period 1990 females consistently experienced a higher than males, their increasing 92.01 126.29 impact on intensified peaking 70–74 age group at 294.13 then declining 196.43 those aged 95 above. model projects that 2050, number will reach 15,558,278, increase 7,806,121 2021. Conclusion From attributable intensified, particularly affecting females, younger elderly, developed regions. With aging obesity is expected continue rapidly without sustained effective targeted interventions.
Язык: Английский
Процитировано
4
Medicine, Год журнала: 2025, Номер 104(3), С. e41248 - e41248
Опубликована: Янв. 17, 2025
Observational epidemiological studies indicate a higher fracture incidence in rheumatoid arthritis (RA) patients compared to the general population. However, causal relationship between RA and risk, particularly traumatic osteoporotic fractures, is not well established. We performed Mendelian randomization (MR) analysis evaluate risk. MR using summary statistics from genome-wide association investigate risk of fractures at 9 sites 3 types fractures. The primary used inverse-variance weighting, supplemented by MR-Egger regression other methods assess relationships sensitivity analyses, including heterogeneity pleiotropy assessments, R software with appropriate packages. weighting results demonstrated genetically predicted an elevated long bones shoulder upper arm (odds ratio [OR] = 1.041, 95% confidence interval [CI]: 1.020–1.062, P 9.06e-05), forearm (OR 1.026, CI: 1.007–1.044, .006), femur 1.036, 1.009–1.064, .009), lower leg, joint 1.031, 1.016–1.047, 6.38e-05), rib(s), sternum, thoracic vertebrae 1.018–1.064, 4.08e-04), pathological features 1.128, 1.071–1.188, 5.54e-06), postmenopausal 1.060, 1.002–1.123, .044), drug-induced 1.255, 1.124–1.400, 5.02e-05). This study highlights genetic link increased presenting new direction for future exploration mechanisms underlying RA-related
Язык: Английский
Процитировано
0
International Journal of Rheumatic Diseases, Год журнала: 2025, Номер 28(2)
Опубликована: Фев. 1, 2025
ABSTRACT Background Although chronic inflammatory arthropathies (CIA) are associated with sarcopenia, sarcopenia plays a role in their pathogenesis remains unknown. This study investigated the causal relationship between and CIA to identify potential mediating factors. Methods We examined data from 458 910 participants UK Biobank analyze association sarcopenia‐related traits CIA. Associations hand‐grip strength, muscle mass, walking pace, were analyzed using Cox regression models. Then, we performed mediation analysis explore underlying mechanisms. Results Individuals low strength exhibited 1.88‐fold (95% CI 1.73–2.05), 2.22‐fold 2.02–2.45), 1.36‐fold 1.32–1.41) increased risk of rheumatoid arthritis (RA), spondyloarthritis (SpA), osteoarthritis (OA), respectively. The HRs for 1.64 1.15–2.32) RA, 1.83 1.21–2.77) SpA, 1.26 1.09–1.45) OA. Additionally, individuals slow pace 1.83‐fold 1.66–2.02), 3.58‐fold 3.25–3.95), 1.82‐fold 1.77–1.88) OA, Furthermore, identified markers as possible mediators effects on development Conclusions Our findings suggest that is independently an CIA, which partially mediated by inflammation
Язык: Английский
Процитировано
0
Frontiers in Endocrinology, Год журнала: 2025, Номер 16
Опубликована: Фев. 4, 2025
Serum urate (SU) levels are significantly elevated in conditions such as gout, type 2 diabetes (T2D), obesity, and other metabolic syndromes. Recently, due to the high prevalence of hyperuricemia (HUA), numerous clinical connections between SU musculoskeletal disorders like sarcopenia, osteoarthritis (OA), rheumatoid arthritis (RA), intervertebral disc degeneration (IDD), osteoporosis (OP) have been identified. This review discusses mechanisms linking disorders, well associations with T2D McArdle disease, heart failure, OA, IDD, OP exercise-induced acute kidney injury (EIAKI), offering valuable insights for improved prevention treatment strategies. Mechanisms include oxidative stress, MSU (monosodium urate) crystal deposition, inflammation, factors. In adults, both age should be considered preventing while gender may directly impact muscle mass children adolescents. HUA gout risk factors OA progression, although some reports suggest otherwise. A U-shaped relationship IDD has reported, particularly Chinese men, indicating lower or higher level IDD. Maintaining within a certain range help prevent fractures. Future research, including epidemiological studies new pathogenesis findings, will further clarify diseases SU.
Язык: Английский
Процитировано
0
Dysphagia, Год журнала: 2025, Номер unknown
Опубликована: Фев. 5, 2025
Язык: Английский
Процитировано
0
Journal of Clinical Medicine, Год журнала: 2025, Номер 14(4), С. 1138 - 1138
Опубликована: Фев. 10, 2025
Osteoporosis is defined as a condition of increased risk fracture due to decreased bone strength. In developed countries, the number patients with osteoporosis and fragility fractures has been increasing in recent years growing elderly population, posing social challenge not only their families but also healthcare economy. can be divided into two categories: primary caused by aging or menopause secondary metabolic inflammatory diseases drugs such glucocorticoids. The majority have osteoporosis, pathogenesis postmenopausal factors associated elucidated. On other hand, rheumatoid arthritis (RA) one causes osteoporosis. RA chronic disease characterized joint swelling destruction. Most often, treatment focuses on suppressing these symptoms. However, physicians should aware patients, because (1) disease, which itself factor for osteoporosis; (2) glucocorticoids, are sometimes administered treat RA, (3) becoming older, an factor. A comprehensive understanding its requires elucidating mechanisms underlying osteoclast activation, drives development. Furthermore, identifying essential. This review summarizes fractures, associations between
Язык: Английский
Процитировано
0
Cells, Год журнала: 2025, Номер 14(5), С. 317 - 317
Опубликована: Фев. 20, 2025
Skeletal muscle wasting is commonly observed in aging, immobility, and chronic diseases. In pathological conditions, the impairment of skeletal immune system often occurs simultaneously. Recent studies have highlighted initiative role interactions with cells. However, impact on macrophage inflammatory responses remains poorly understood. To investigate effect atrophic myotubes response macrophages, we established two vitro models to induce myotube atrophy: one induced by D-galactose other starvation. Conditioned medium (CM) from normal were collected administered bone marrow-derived macrophages (BMDMs) mice. Subsequently, lipopolysaccharide (LPS) stimulation was applied, expression cytokines measured via RT-qPCR. Both starvation treatments reduced diameter upregulated atrophy-related gene expression. CM both augmented pro-inflammatory factors BMDMs following LPS stimulation, including Il6, Il1b, Nfkb1. Notably, starvation-induced also enhanced Il12b, Tnf, Nos2 after a not D-galactose-induced myotubes. These findings suggest that LPS-induced mediators macrophages.
Язык: Английский
Процитировано
0