Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 8, 2024
Due
to
the
vital
importance
of
lungs,
lung-related
diseases
and
their
control
are
very
important.
Severe
inflammatory
responses
mediated
by
immune
cells
were
among
leading
causes
lung
tissue
pathology
damage
during
COVID-19
pandemic.
In
addition,
uncontrolled
cell
can
lead
in
other
infectious
non-infectious
diseases.
It
is
essential
a
way
that
leads
homeostasis.
Immunosuppressive
drugs
only
suppress
do
not
affect
homeostasis
reactions.
The
therapeutic
application
mesenchymal
stem
(MSCs),
addition
restoring
homeostasis,
promote
regeneration
through
production
growth
factors
differentiation
into
cells.
However,
communication
between
MSCs
after
treatment
pulmonary
essential,
investigating
this
help
develop
clinical
perspective.
Different
studies
phase
showed
reverse
fibrosis,
increase
regeneration,
airway
remodeling,
reduce
tissue.
proliferation
potential
one
mechanisms
effects.
Furthermore,
they
secrete
exosomes
function
change
function.
Another
important
mechanism
harmful
with
innate
adaptive
cells,
which
shift
system
toward
regulatory
hemostatic
responses.
Biomaterials Research,
Год журнала:
2024,
Номер
28
Опубликована: Янв. 1, 2024
Cartilage
repair
is
the
key
to
treatment
of
joint-related
injury.
However,
because
cartilage
lacks
vessels
and
nerves,
its
self-repair
ability
extremely
low.
Extracellular
vesicles
(EVs)
are
bilayer
nanovesicles
with
membranes
mainly
composed
ceramides,
cholesterol,
phosphoglycerides,
long-chain
free
fatty
acids,
containing
DNA,
RNA,
proteins
(such
as
integrins
enzymes).
For
mediating
intercellular
communication
regulating
mechanisms,
EVs
have
been
shown
by
multiple
studies
be
effective
options
for
repair.
This
review
summarizes
recent
findings
different
sources
(mammals,
plants,
bacteria)
uses
in
repair,
mechanisms
captured
injured
chondrocytes,
quantification
storage
EVs,
which
may
provide
scientific
guidance
promoting
development
field
injury
treatment.
Clinical and Experimental Hypertension,
Год журнала:
2024,
Номер
46(1)
Опубликована: Июнь 12, 2024
To
elucidate
the
underlying
mechanism
by
which
proliferation
and
migration
abilities
of
human
umbilical
cord
mesenchymal
stem
cells
(hUC-MSCs)
determine
their
therapeutic
efficacy
in
rheumatoid
arthritis
treatment.
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
19(6), С. 100965 - 100965
Опубликована: Сен. 4, 2024
Ischemia/reperfusion
(I/R)
injury
is
marked
by
the
restriction
and
subsequent
restoration
of
blood
supply
to
an
organ.
This
process
can
exacerbate
initial
tissue
damage,
leading
further
disorders,
disability,
even
death.
Extracellular
vesicles
(EVs)
are
crucial
in
cell
communication
releasing
cargo
that
regulates
physiological
state
recipient
cells.
The
development
EVs
presents
a
novel
avenue
for
delivering
therapeutic
agents
I/R
therapy.
potential
derived
from
stem
cells,
endothelial
plasma
has
been
actively
investigated.
Therefore,
this
review
aims
provide
overview
pathological
biophysical
properties
EVs.
We
noted
serve
as
nontoxic,
flexible,
multifunctional
carriers
capable
intervening
progression.
efficacy
be
enhanced
through
various
engineering
strategies.
Improving
tropism
Although,
extracellular
vesicles
(EVs)
appear
as
future
promising
therapeutics,
their
in
vivo
instability
after
administration
remains
an
important
barrier
to
development.
While
many
groups
have
evaluated
EV
surface
modification
strategies
add
a
targeting
group
control
biodistribution,
far
fewer
focused
on
stabilization
obtain
"stealth"
allogenic
EVs.
This
aspect
is
fundamental
prerequisite
for
development
nano
therapeutics.
Here,
we
explored
lipid
anchorage
the
membrane
of
PEG
alternative,
polyoxazoline,
stabilize
EVs
plasma
and
biodistribution
while
preserving
native
properties.
We
determined
that
this
maintained
immunomodulatory
properties
derived
from
mesenchymal
stem/stromal
cells.
Interestingly,
POxylation
seemed
potentiate
effect.
Using
radiolabeling
protocol
track
therapeutically
relevant
number
vivo,
demonstrated
option
stabilizing
plasma,
increasing
half-life
by
6-fold
at
6
hours
injection,
surpassing
modified
tumor
accumulation.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 8, 2024
Due
to
the
vital
importance
of
lungs,
lung-related
diseases
and
their
control
are
very
important.
Severe
inflammatory
responses
mediated
by
immune
cells
were
among
leading
causes
lung
tissue
pathology
damage
during
COVID-19
pandemic.
In
addition,
uncontrolled
cell
can
lead
in
other
infectious
non-infectious
diseases.
It
is
essential
a
way
that
leads
homeostasis.
Immunosuppressive
drugs
only
suppress
do
not
affect
homeostasis
reactions.
The
therapeutic
application
mesenchymal
stem
(MSCs),
addition
restoring
homeostasis,
promote
regeneration
through
production
growth
factors
differentiation
into
cells.
However,
communication
between
MSCs
after
treatment
pulmonary
essential,
investigating
this
help
develop
clinical
perspective.
Different
studies
phase
showed
reverse
fibrosis,
increase
regeneration,
airway
remodeling,
reduce
tissue.
proliferation
potential
one
mechanisms
effects.
Furthermore,
they
secrete
exosomes
function
change
function.
Another
important
mechanism
harmful
with
innate
adaptive
cells,
which
shift
system
toward
regulatory
hemostatic
responses.
