Membrane biomimetic nanoenzyme-incorporated hybrid glycyrrhizic acid hydrogel for precise mitochondrial ROS scavenging for osteoarthritis treatment

Materials Today Bio, Год журнала: 2025, Номер 32, С. 101778 - 101778

Опубликована: Апрель 17, 2025

Osteoarthritis (OA) is a progressive degenerative disorder which severely threatens the quality of life older individuals. OA progression closely related to heightened levels mitochondrial reactive oxygen species (mtROS). Although nanozymes have good ROS-scavenging effect, they cannot precisely scavenge mtROS because immune rejection cell membranes, lysosomal escape, and inability conventional directly target mitochondria. Dual-target were engineered in chondrocytes. We used chondrocyte membrane-camouflaged TPP-modified hollow Prussian blue subsequently encapsulated these hybrid glycyrrhizic acid hydrogel. The therapeutic efficacy underlying mechanisms assessed vitro vivo. novel enhanced selectivity, evasion capabilities, targeting. dual-targeted exerted pronounced impact on inflammatory chondrocytes, mitigated mtDNA leakage by scavenging mtROS, dampened cGAS-STING-NF-κB signaling, function. hydrogels also exhibited improved outcomes. confirmed beneficial effects nanozyme-hydrogel combination mice. can reduce avoiding suppressing signaling pathway, thereby decreasing responses alleviate progression.

Язык: Английский

Adaptive hydrogel loaded with pre-coordinated stem cells for enhanced osteoarthritis therapy

Bioactive Materials, Год журнала: 2025, Номер 51, С. 613 - 633

Опубликована: Май 28, 2025

Язык: Английский