ACS Medicinal Chemistry Letters,
Год журнала:
2022,
Номер
13(7), С. 1052 - 1061
Опубликована: Июнь 21, 2022
Overactive
bladder
(OAB)
is
a
syndrome
causing
sudden
and
unstoppable
need
to
urinate
with
significant
global
prevalence.
Several
drugs
are
used
treat
OAB;
however,
they
have
various
side
effects.
Therefore,
new
treatment
options
for
OAB
required.
A
series
of
novel
5-oxo-N-phenyl-1-thioxo-4,5-dihydro-1H-thiazolo[3,4-a]quinazoline-3-carboxamide
derivatives
were
synthesized
evaluated
their
large-conductance
voltage-
Ca2+-activated
K+
channel
activation
through
cell-based
fluorescence
assay
electrophysiological
recordings.
compounds,
including
7-bromo
substituent
on
the
heterocyclic
system,
showed
increased
currents.
Among
derivatives,
compound
12h
exhibited
potent
in
vitro
activity
half-maximal
effective
concentration
(EC50)
2.89
μM,
good
oral
pharmacokinetic
properties
(area
under
curve
half-life),
vivo
efficacy
spontaneously
hypertensive
rat
model.
Continence,
Год журнала:
2022,
Номер
1, С. 100022 - 100022
Опубликована: Март 1, 2022
The
management
of
patients
with
neurogenic
lower
urinary
tract
dysfunction
has
been
well-described,
however
this
is
most
frequently
discussed
for
common
conditions
such
as
spinal
cord
injury
or
multiple
sclerosis.
Our
objective
was
to
review
uncommon
neurologic
disorders
and
summarize
both
the
underlying
disease
process,
relevant
disease-specific
research
on
impact
condition
tract.
Among
degenerative
traumatic
brain
disorders,
we
have
included
frontotemporal
dementia,
amyotrophic
lateral
sclerosis,
Huntington's
Disease,
progressive
supranuclear
palsy,
corticobasal
degeneration,
system
atrophy,
injury.
autoimmune
reviewed
transverse
myelitis,
neuromyelitis
optica
spectrum
Myelin
oligodendrocyte
glycoprotein
antibody-associated
disease,
glial
fibrillary
acidic
protein
astrocytopathy,
meningitis-retention
syndrome
(a
form
aseptic
meningitis
that
presents
retention).
Hereditary
spastic
paraplegia,
VACTERL
association,
several
peripheral
neuropathies
(Guillain
Barre
syndrome,
chronic
inflammatory
demyelinating
polyneuropathy,
autonomic
gangliopathy,
Wolfram
disorder
neuropathy
early
onset
diabetes,
optic
atrophy
megacystis
in
stage),
Charcot
Marie
Tooth
amyloid
are
included.
Practice
points
specific
where
appropriate.
Frontiers in Oncology,
Год журнала:
2023,
Номер
13
Опубликована: Май 2, 2023
To
evaluate
the
effects
of
mirabegron
in
treatment
overactive
bladder
syndrome
(OAB)
after
radical
prostatectomy
(RP).A
total
108
post-operative
RP
patients
were
randomly
assigned
to
either
(study)
or
placebo
(control)
group.
The
Overactive
Bladder
Syndrome
Self-Assessment
Scale
(OABSS)
was
selected
as
primary
endpoint,
and
International
Prostate
Symptom
Score
(IPSS)
Quality
Life
(QOL)
score
secondary
endpoints.
Statistical
analysis
performed
using
IBM
SPSS
Statistics
26,
compared
between
two
groups
independent
samples
t-test.In
total,
55
included
study
group
53
control
mean
age
was(70.08
±
7.54)years.
There
no
statistical
difference
baseline
data
groups.
OABSS
scores
decreased
significantly
during
drug
(6.67
1.06
vs.
9.14
1.83,
p
<
0.01)
better
than
follow-up
at
week
8
12.
In
addition,
decrease
IPSS
(11.29
3.89
15.34
3.54,
p<0.01)
increase
QOL
(2.40
0.81
3.20
1.00)
statistically
significant
And
had
improvement
voiding
symptoms
quality
life
period.Daily
administration
50
mg
surgery
improved
OAB
with
fewer
side
effects.
Additional
randomized
controlled
trials
should
be
conducted
future
further
efficacy
safety
mirabegron.
Urogynecology,
Год журнала:
2022,
Номер
29(5), С. 497 - 503
Опубликована: Ноя. 12, 2022
Importance
There
are
significant
associations
between
anticholinergic
medication
use
and
an
increased
risk
of
cognitive
impairment
dementia.
Many
experts
now
advocate
minimizing
the
medications
to
treat
overactive
bladder
(OAB)
in
elderly
women.
Objective
The
aim
this
study
was
describe
temporal
geographic
trends
pharmacologic
treatment
OAB
for
patients
65
years
or
older
across
United
States.
Study
Design
U.S.
Centers
Medicare
&
Medicaid
Services
publishes
annual
Provider
Utilization
Payment
Data.
data
set
includes
number
unique
Part
D
beneficiaries
with
at
least
1
claim
a
drug
30-day
fills
dispensed.
database
also
state
rural-urban
commuting
area
designation
prescriber.
Results
From
2013
2019,
received
47.7
million
OAB.
In
2013,
anticholinergics
represented
98%
total
(5.6
million)
β3
agonists
nearly
24
times
greater
2019
than
2013.
Geographic
variation
prescribing
practices
evident.
Conclusions
dispensed
remained
relatively
stable,
there
substantial
increase
agonists.
Percentages
varied
among
states.
More
being
treated
OAB;
however,
comprised
majority
prescriptions
2019.
ACS Medicinal Chemistry Letters,
Год журнала:
2022,
Номер
13(7), С. 1052 - 1061
Опубликована: Июнь 21, 2022
Overactive
bladder
(OAB)
is
a
syndrome
causing
sudden
and
unstoppable
need
to
urinate
with
significant
global
prevalence.
Several
drugs
are
used
treat
OAB;
however,
they
have
various
side
effects.
Therefore,
new
treatment
options
for
OAB
required.
A
series
of
novel
5-oxo-N-phenyl-1-thioxo-4,5-dihydro-1H-thiazolo[3,4-a]quinazoline-3-carboxamide
derivatives
were
synthesized
evaluated
their
large-conductance
voltage-
Ca2+-activated
K+
channel
activation
through
cell-based
fluorescence
assay
electrophysiological
recordings.
compounds,
including
7-bromo
substituent
on
the
heterocyclic
system,
showed
increased
currents.
Among
derivatives,
compound
12h
exhibited
potent
in
vitro
activity
half-maximal
effective
concentration
(EC50)
2.89
μM,
good
oral
pharmacokinetic
properties
(area
under
curve
half-life),
vivo
efficacy
spontaneously
hypertensive
rat
model.
