Annual Review of Immunology,
Год журнала:
2018,
Номер
37(1), С. 173 - 200
Опубликована: Дек. 14, 2018
Malignant
transformation
of
cells
depends
on
accumulation
DNA
damage.
Over
the
past
years
we
have
learned
that
T
cell-based
immune
system
frequently
responds
to
neoantigens
arise
as
a
consequence
this
Furthermore,
recognition
appears
an
important
driver
clinical
activity
both
cell
checkpoint
blockade
and
adoptive
therapy
cancer
immunotherapies.
Here
review
evidence
for
relevance
in
tumor
control
biological
properties
these
antigens.
We
discuss
recent
technological
advances
utilized
identify
neoantigens,
recognize
them,
individual
patients.
Finally,
strategies
can
be
employed
exploit
interventions.
Cellular and Molecular Immunology,
Год журнала:
2020,
Номер
17(8), С. 807 - 821
Опубликована: Июль 1, 2020
Abstract
Immunotherapy
has
revolutionized
cancer
treatment
and
rejuvenated
the
field
of
tumor
immunology.
Several
types
immunotherapy,
including
adoptive
cell
transfer
(ACT)
immune
checkpoint
inhibitors
(ICIs),
have
obtained
durable
clinical
responses,
but
their
efficacies
vary,
only
subsets
patients
can
benefit
from
them.
Immune
infiltrates
in
microenvironment
(TME)
been
shown
to
play
a
key
role
development
will
affect
outcomes
patients.
Comprehensive
profiling
tumor-infiltrating
cells
would
shed
light
on
mechanisms
cancer–immune
evasion,
thus
providing
opportunities
for
novel
therapeutic
strategies.
However,
highly
heterogeneous
dynamic
nature
TME
impedes
precise
dissection
intratumoral
cells.
With
recent
advances
single-cell
technologies
such
as
RNA
sequencing
(scRNA-seq)
mass
cytometry,
systematic
interrogation
is
feasible
provide
insights
into
functional
diversities
In
this
review,
we
outline
progress
particularly
by
focusing
landmark
studies
characterization
tumor-associated
cells,
summarize
phenotypic
connections
with
immunotherapy.
We
believe
review
could
strengthen
our
understanding
facilitate
elucidation
modulation
progression,
guide
immunotherapies
treatment.
Annual Review of Immunology,
Год журнала:
2019,
Номер
37(1), С. 457 - 495
Опубликована: Янв. 24, 2019
Exhausted
CD8
T
(Tex)
cells
are
a
distinct
cell
lineage
that
arise
during
chronic
infections
and
cancers
in
animal
models
humans.
Tex
characterized
by
progressive
loss
of
effector
functions,
high
sustained
inhibitory
receptor
expression,
metabolic
dysregulation,
poor
memory
recall
homeostatic
self-renewal,
transcriptional
epigenetic
programs.
The
ability
to
reinvigorate
through
blockade,
such
as
αPD-1,
highlights
the
therapeutic
potential
targeting
this
population.
Emerging
insights
into
mechanisms
exhaustion
informing
immunotherapies
for
cancer
infections.
However,
like
other
immune
cells,
heterogeneous
include
progenitor
terminal
subsets
with
unique
characteristics
responses
checkpoint
blockade.
Here,
we
review
our
current
understanding
biology,
including
developmental
paths,
features,
intrinsic
extrinsic
factors
contributing
how
knowledge
may
inform
infections,
autoimmunity,
cancer.
