Mitochondrion, Год журнала: 2023, Номер 70, С. 59 - 102
Опубликована: Март 1, 2023
Язык: Английский
Immunological Reviews, Год журнала: 2022, Номер 314(1), С. 357 - 375
Опубликована: Окт. 31, 2022
Over the past millennia, life expectancy has drastically increased. While a mere 25 years during Bronze and Iron ages, in many European countries Japan is currently above 80 years. Such an increase result of improved diet, style, medical care. Yet, increased span aging also represent most important non-modifiable risk factors for several pathologies including cardiovascular disease, neurodegenerative diseases, cancer. In recent years, neutrophils have been implicated all these pathologies. Hence, this review provides overview how impacts neutrophil production function conversely drive aging-associated Finally, we provide perspective on processes neutrophil-driven context can be targeted therapeutically.
Язык: Английский
Процитировано
63
Cancers, Год журнала: 2022, Номер 14(20), С. 5071 - 5071
Опубликована: Окт. 17, 2022
Living organisms present rhythmic fluctuations every 24 h in their behavior and metabolism to anticipate changes the environment. These are controlled by a very complex molecular mechanism, circadian clock, that regulates expression of multiple genes ensure right functioning body. An individual’s system is altered during aging, this related numerous age-associated pathologies other alterations could contribute development cancer. Nowadays, there an increasing interest understanding how rhythms be used treatment Chronotherapy aims understand impact biological have on response therapy optimize its action, maximize health benefits minimize possible adverse effects. Clinical trials so far confirmed optimal timing with chemo or immunotherapies decrease drug toxicity increase efficacy. Instead, chronoradiotherapy seems treatment-related symptoms rather than tumor progression patient survival. In addition, potential therapeutic targets within clock also been identified. Therefore, results application chronotherapy cancer until now challenging, feasible, applied clinical practice improve without additional costs. However, different limitations variables such as age, sex, chronotypes, among others, should overcome before can really put into practice.
Язык: Английский
Процитировано
48
Journal for ImmunoTherapy of Cancer, Год журнала: 2022, Номер 10(12), С. e005615 - e005615
Опубликована: Дек. 1, 2022
Cancer-related deaths are mainly caused by metastatic spread of tumor cells from the primary lesion to distant sites via blood circulation. Understanding mechanisms blood-borne cell dissemination detection and molecular characterization circulating (CTCs) in patients with cancer has opened a new avenue research. Recent technical advances have enabled comprehensive analysis CTCs at genome, transcriptome protein level as well first functional studies using patient-derived CTC lines. In this review, we describe discuss how research on yielded important insights into biology metastasis response therapies directed against cells. Future investigations will show whether leaving their site more vulnerable attacks immune effector might be 'Achilles heel' progression. Here, focus lessons learned particular emphasis interactions system. Moreover, briefly potential challenges for implementing clinical decision-making including minimal residual disease, monitoring efficacies systemic identification therapeutic targets resistance mechanisms.
Язык: Английский
Процитировано
42
Annual Review of Neuroscience, Год журнала: 2023, Номер 46(1), С. 123 - 143
Опубликована: Фев. 28, 2023
This review explores the interface between circadian timekeeping and regulation of brain function by astrocytes. Although astrocytes regulate neuronal activity across many time domains, their cell-autonomous clocks exert a particular role in controlling longer-term oscillations function: maintenance sleep states ordering wakefulness. is most evident central pacemaker, suprachiasmatic nucleus, where molecular clock suffices to drive daily cycles behavior. In Alzheimer's disease, impairments accompany cognitive decline. mouse models disturbances accelerate astroglial activation other pathologies, suggesting that functions protect homeostasis. cancer, treatment morning has been associated with prolonged survival, gliomas have rhythms gene expression drug sensitivity. Thus, fast becoming critical elucidating reciprocal astrocytic-neuronal interactions health disease.
Язык: Английский
Процитировано
33
Mitochondrion, Год журнала: 2023, Номер 70, С. 59 - 102
Опубликована: Март 1, 2023
Язык: Английский
Процитировано
31