International Immunopharmacology, Год журнала: 2024, Номер 132, С. 111995 - 111995
Опубликована: Апрель 5, 2024
Язык: Английский
Immunity, Год журнала: 2024, Номер 57(4), С. 649 - 673
Опубликована: Апрель 1, 2024
Язык: Английский
Процитировано
84
Nature Reviews Microbiology, Год журнала: 2024, Номер 22(11), С. 687 - 704
Опубликована: Июнь 25, 2024
Язык: Английский
Процитировано
25
Journal of Fungi, Год журнала: 2022, Номер 8(10), С. 1069 - 1069
Опубликована: Окт. 12, 2022
Cryptococcus neoformans (C. neoformans) is a pathogenic fungus with global distribution. Humans become infected by inhaling the from environment, and initially colonizes lungs. If immune system fails to contain C. in lungs, can disseminate blood invade central nervous system, resulting fatal meningoencephalitis particularly immunocompromised individuals including HIV/AIDS patients. Following brain invasion, will encounter host defenses involving resident as well recruited cells brain. To overcome defenses, possesses multiple virulence factors capable of modulating responses. The outcome interactions between determine disease progression. In this review, we describe current understanding how migrates across blood–brain barrier, responds invading organism We also discuss that uses modulate
Язык: Английский
Процитировано
48
Seminars in Immunology, Год журнала: 2023, Номер 66, С. 101728 - 101728
Опубликована: Фев. 24, 2023
Язык: Английский
Процитировано
39
Trends in Microbiology, Год журнала: 2023, Номер 32(3), С. 302 - 316
Опубликована: Сен. 29, 2023
Язык: Английский
Процитировано
34
Frontiers in Allergy, Год журнала: 2023, Номер 3
Опубликована: Янв. 10, 2023
Allergic diseases, including atopic dermatitis, allergic rhinitis, asthma, and food allergy, are caused by abnormal responses to relatively harmless foreign proteins called allergens found in pollen, fungal spores, house dust mites (HDM), animal dander, or certain foods. In particular, the activation of allergen-specific helper T cells towards a type 2 (Th2) phenotype during first encounters with allergen, also known as sensitization phase, is leading cause subsequent development disease. Infants children especially prone developing Th2 cell after initial contact allergens. But addition, rates diseases among increasing industrialized world have been associated living urban settings. Particularly for respiratory allergies, greater susceptibility has shown environments containing low levels microbial contaminants, principally bacterial endotoxins [lipopolysaccharide (LPS)], causative aeroallergens. This review highlights current understanding factors that balance immunity environmental allergens, particular focus on determinants program conventional dendritic (cDCs) toward away from stimulatory function. this context, it discusses transcription factor-guided functional specialization type-2 cDCs (cDC2s) how integration signals derived environment drives process. analyzes observational mechanistic studies supporting an essential role innate sensing microbial-derived products contained aeroallergens modulating immune responses. Finally, examines whether hyporesponsiveness stimulation, particularly LPS, risk factor induction infancy early childhood potential may affect early-age response LPS other components.
Язык: Английский
Процитировано
29
Immunity, Год журнала: 2023, Номер 56(7), С. 1548 - 1560.e5
Опубликована: Июнь 5, 2023
Cryptococcus neoformans is the leading cause of fungal meningitis and characterized by pathogenic eosinophil accumulation in context type-2 inflammation. The chemoattractant receptor GPR35 expressed granulocytes promotes their migration to inflammatory mediator 5-hydroxyindoleacetic acid (5-HIAA), a serotonin metabolite. Given nature cryptococcal infection, we examined role circuitry underlying cell recruitment lung. deficiency dampened growth, whereas overexpression promoted homing airways replication. Activated platelets mast cells were sources ligand activity pharmacological inhibition conversion 5-HIAA, or genetic 5-HIAA production resulted more efficient clearance Cryptococcus. Thus, 5-HIAA-GPR35 axis an system that modulates lethal pathogen, with implications for use metabolism inhibitors treatment infections.
Язык: Английский
Процитировано
24
Current Opinion in Microbiology, Год журнала: 2024, Номер 81, С. 102526 - 102526
Опубликована: Авг. 24, 2024
Fungal effector proteins function at the interfaces of diverse interactions between fungi and their plant animal hosts, facilitating that are pathogenic or mutualistic. Recent advancements in protein structure prediction have significantly accelerated identification functional predictions these rapidly evolving proteins. This development enables scientists to generate testable hypotheses for validation using experimental approaches. Research frontiers biology include understanding pathways through which secreted translocated into host cells, roles manipulating microbiomes, contribution interacting with immunity. Comparative repertoires among different fungal-host can highlight unique adaptations, providing insights novel antifungal therapies biocontrol strategies.
Язык: Английский
Процитировано
7
Nature Microbiology, Год журнала: 2024, Номер 9(9), С. 2216 - 2231
Опубликована: Авг. 26, 2024
Язык: Английский
Процитировано
5
iScience, Год журнала: 2023, Номер 26(5), С. 106717 - 106717
Опубликована: Апрель 23, 2023
How lung macrophages, especially interstitial macrophages (IMs), respond to invading pathogens remains elusive. Here, we show that mice exhibited a rapid and substantial expansion of CX3CR1
Язык: Английский
Процитировано
11