Biomarker Research,
Год журнала:
2025,
Номер
13(1)
Опубликована: Янв. 23, 2025
Neutrophil
extracellular
traps
(NETs)
are
intricate,
web-like
formations
composed
of
DNA,
histones,
and
antimicrobial
proteins,
released
by
neutrophils.
These
structures
participate
in
a
wide
array
physiological
pathological
activities,
including
immune
rheumatic
diseases
damage
to
target
organs.
Recently,
the
connection
between
NETs
cancer
has
garnered
significant
attention.
Within
tumor
microenvironment
metabolism,
exhibit
multifaceted
roles,
such
as
promoting
proliferation
migration
cells,
influencing
redox
balance,
triggering
angiogenesis,
driving
metabolic
reprogramming.
This
review
offers
comprehensive
analysis
link
emphasizing
areas
that
remain
underexplored.
include
interaction
with
mitochondria,
their
effect
on
states
within
tumors,
involvement
reprogramming,
contribution
angiogenesis
tumors.
Such
insights
lay
theoretical
foundation
for
deeper
understanding
role
development.
Moreover,
also
delves
into
potential
therapeutic
strategies
suggests
future
research
directions,
offering
new
perspectives
treatment
other
related
diseases.
Cell Death and Disease,
Год журнала:
2024,
Номер
15(1)
Опубликована: Янв. 13, 2024
Abstract
Amino
acid
metabolism
plays
important
roles
in
tumor
biology
and
therapy.
Accumulating
evidence
has
shown
that
amino
acids
contribute
to
tumorigenesis
immunity
by
acting
as
nutrients,
signaling
molecules,
could
also
regulate
gene
transcription
epigenetic
modification.
Therefore,
targeting
will
provide
new
ideas
for
treatment
become
an
therapeutic
approach
after
surgery,
radiotherapy,
chemotherapy.
In
this
review,
we
systematically
summarize
the
recent
progress
of
malignancy
their
interaction
with
signal
pathways
well
effect
on
microenvironment
Collectively,
highlight
potential
application
future
expectation.
Cell,
Год журнала:
2024,
Номер
187(9), С. 2052 - 2078
Опубликована: Апрель 1, 2024
Adaptive
immunity
provides
protection
against
infectious
and
malignant
diseases.
These
effects
are
mediated
by
lymphocytes
that
sense
respond
with
targeted
precision
to
perturbations
induced
pathogens
tissue
damage.
Here,
we
review
key
principles
underlying
adaptive
orchestrated
distinct
T
cell
B
populations
their
extensions
disease
therapies.
We
discuss
the
intracellular
intercellular
processes
shaping
antigen
specificity
recognition
in
immune
activation
lymphocyte
functions
mediating
effector
memory
responses.
also
describe
how
balance
protective
autoimmunity
immunopathology,
including
during
tolerance,
response
chronic
stimulation,
adaptation
non-lymphoid
tissues
coordinating
homeostasis.
Finally,
extracellular
signals
cell-intrinsic
programs
underpinning
conclude
summarizing
advances
vaccination
engineering
responses
for
therapeutic
interventions.
A
deeper
understanding
of
these
holds
promise
uncovering
new
means
improve
human
health.
The Journal of Experimental Medicine,
Год журнала:
2024,
Номер
221(3)
Опубликована: Фев. 27, 2024
T
cells
are
integral
in
mediating
adaptive
immunity
to
infection,
autoimmunity,
and
cancer.
Upon
immune
challenge,
exit
from
a
quiescent
state,
followed
by
clonal
expansion
effector
differentiation.
These
processes
shaped
three
established
signals,
namely
antigen
stimulation
(Signal
1),
costimulation
2),
cytokines
3).
Emerging
findings
reveal
that
nutrients,
including
glucose,
amino
acids,
lipids,
crucial
regulators
of
cell
responses
interplay
with
Signals
1-3,
highlighting
nutrients
as
Signal
4
license
immunity.
Here,
we
first
summarize
the
functional
importance
underlying
mechanisms
nutrient
transport,
sensing,
signaling
orchestrating
activation
quiescence
exit.
We
also
discuss
roles
programming
differentiation
fitness
how
can
be
targeted
improve
disease
therapy.
Understanding
respond
microenvironments
will
provide
insights
into
context-dependent
functions
therapeutic
interventions.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Окт. 9, 2024
Metabolism,
including
glycolysis,
oxidative
phosphorylation,
fatty
acid
oxidation,
and
other
metabolic
pathways,
impacts
the
phenotypes
functions
of
immune
cells.
The
regulation
system
is
important
in
pathogenesis
progression
numerous
diseases,
such
as
cancers,
autoimmune
diseases
diseases.
concept
immunometabolism
was
introduced
over
a
decade
ago
to
elucidate
intricate
interplay
between
metabolism
immunity.
definition
has
expanded
from
chronic
low-grade
inflammation
reprogramming
cells
various
With
being
proposed
developed,
can
be
gradually
summarized
becomes
more
clearer.
In
context
many
cancer,
disease,
occurs
inducing
proinflammatory
or
anti-inflammatory
effects.
phenotypic
functional
changes
caused
by
further
affect
development
Based
on
experimental
results,
targeting
cellular
promising
therapy.
this
review,
we
focus
introduce
their
pathways
reprogramming,
summarize
how
these
effects
We
thoroughly
explore
targets
treatments
based
existing
studies.
challenges
translating
results
into
clinical
applications
field
are
also
summarized.
believe
that
better
understanding
health
will
improve
management
most
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2024,
Номер
43(1)
Опубликована: Март 8, 2024
Abstract
Glutamine
metabolism
plays
a
pivotal
role
in
cancer
progression,
immune
cell
function,
and
the
modulation
of
tumor
microenvironment.
Dysregulated
glutamine
has
been
implicated
development
responses,
supported
by
mounting
evidence.
Cancer
cells
heavily
rely
on
as
critical
nutrient
for
survival
proliferation,
while
require
activation
proliferation
during
reactions.
This
metabolic
competition
creates
dynamic
tug-of-war
between
cells.
Targeting
transporters
downstream
enzymes
involved
holds
significant
promise
enhancing
anti-tumor
immunity.
A
comprehensive
understanding
intricate
molecular
mechanisms
underlying
this
interplay
is
crucial
developing
innovative
therapeutic
approaches
that
improve
immunity
patient
outcomes.
In
review,
we
provide
overview
recent
advances
unraveling
explore
potential
applications
basic
science
discoveries
clinical
setting.
Further
investigations
into
regulation
are
expected
to
yield
valuable
insights,
paving
way
future
interventions.
ACS Nano,
Год журнала:
2024,
Номер
18(3), С. 1846 - 1864
Опубликована: Янв. 5, 2024
Mutation
burden,
hypoxia,
and
immunoediting
contribute
to
altered
metabolic
profiles
in
tumor
cells,
resulting
a
microenvironment
(TME)
characterized
by
accumulation
of
toxic
metabolites
depletion
various
nutrients,
which
significantly
hinder
the
antitumor
immunity
via
multiple
mechanisms,
hindering
efficacy
immunotherapies.
In-depth
investigation
mechanisms
underlying
these
phenomena
are
vital
for
developing
effective
drugs
therapies,
while
therapeutic
effects
metabolism-targeting
restricted
off-target
toxicity
toward
effector
immune
cells
high
dosage-mediated
side
effects.
Nanotechnologies,
exhibit
versatility
plasticity
targeted
delivery
metabolism
modulation,
have
been
widely
applied
boost
immunometabolic
therapies
strategies,
including
targeting
pathways.
In
this
review,
recent
advances
understanding
roles
cell
both
immunoevasion
immunosuppression
reviewed,
nanotechnology-based
reprogramming
strategies
enhanced
immunotherapies
discussed.
