Netrin-1 blockade inhibits tumor associated Myeloid-derived suppressor cells, cancer stemness and alleviates resistance to chemotherapy and immune checkpoint inhibitor

Cell Death and Differentiation, Год журнала: 2023, Номер 30(10), С. 2201 - 2212

Опубликована: Авг. 26, 2023

Язык: Английский

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Spatial transcriptomics in cancer research and potential clinical impact: a narrative review

Journal of Cancer Research and Clinical Oncology, Год журнала: 2024, Номер 150(6)

Опубликована: Июнь 8, 2024

Spatial transcriptomics (ST) provides novel insights into the tumor microenvironment (TME). ST allows quantification and illustration of gene expression profiles in spatial context tissues, including both cancer cells which they are found. In research, has already provided metastasis, prognosis, immunotherapy responsiveness. The clinical precision oncology application next-generation sequencing (NGS) RNA profiling tumors relies on bulk methods that lack context. ability to preserve information is now possible, as it us capture heterogeneity multifocality. this narrative review, we summarize oncology, discuss clinic, review available research methods, seqFISH, MERFISH (Vizgen), CosMx SMI (NanoString), Xenium (10x), Visium Stereo-seq (STOmics), GeoMx DSP (NanoString). We then current literature with a focus solid organized by type. Finally, conclude addressing an important question: how will ultimately help patients cancer?

Язык: Английский

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Single-cell transcriptome profiles the heterogeneity of tumor cells and microenvironments for different pathological endometrial cancer and identifies specific sensitive drugs

Cell Death and Disease, Год журнала: 2024, Номер 15(8)

Опубликована: Авг. 7, 2024

Endometrial cancer (EC) is a highly heterogeneous malignancy characterized by varied pathology and prognoses, the heterogeneity of its cells tumor microenvironment (TME) remains poorly understood. We conducted single-cell RNA sequencing (scRNA-seq) on 18 EC samples, encompassing various pathological types to delineate their specific unique transcriptional landscapes. Cancer from diverse sources displayed distinct hallmarks labeled as immune-modulating, proliferation-modulating, metabolism-modulating in uterine clear cell carcinomas (UCCC), well-differentiated endometrioid endometrial (EEC-I), serous (USC), respectively. UCCC exhibited greatest heterogeneity. also identified potential effective drugs confirmed effectiveness using patient-derived organoids for each group. Regarding TME, we observed that prognostically favorable CD8

Язык: Английский

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Chronic inflammation and vascular cell plasticity in atherosclerosis

Nature Cardiovascular Research, Год журнала: 2024, Номер 3(12), С. 1408 - 1423

Опубликована: Дек. 9, 2024

Язык: Английский

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Reactivation of embryonic genetic programs in tissue regeneration and disease

Nature Genetics, Год журнала: 2023, Номер 55(11), С. 1792 - 1806

Опубликована: Окт. 30, 2023

Язык: Английский

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The role of stromal cells in epithelial–mesenchymal plasticity and its therapeutic potential

Discover Oncology, Год журнала: 2024, Номер 15(1)

Опубликована: Янв. 20, 2024

Язык: Английский

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Insights from the neural guidance factor Netrin-1 into neurodegeneration and other diseases

Frontiers in Molecular Neuroscience, Год журнала: 2024, Номер 17

Опубликована: Апрель 4, 2024

Netrin-1 was initially discovered as a neuronal growth cue for axonal guidance, and its functions have later been identified in inflammation, tumorigenesis, neurodegeneration, other disorders. We recently found alterations the brains with Alzheimer’s disease, which might provide important clues to mechanisms of some unique pathologies. To better understanding this promising molecule, we here summarize research progresses genetics, pathology, biochemistry, cell biology studies about mechanistic roles biomarker potentials an emphasis on clinical neurodegenerative disorders order expand molecular player human diseases.

Язык: Английский

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Multiplex Digital Spatial Profiling in Breast Cancer Research: State-of-the-Art Technologies and Applications across the Translational Science Spectrum

Cancers, Год журнала: 2024, Номер 16(9), С. 1615 - 1615

Опубликована: Апрель 23, 2024

While RNA sequencing and multi-omic approaches have significantly advanced cancer diagnosis treatment, their limitation in preserving critical spatial information has been a notable drawback. This context is essential for understanding cellular interactions tissue dynamics. Multiplex digital profiling (MDSP) technologies overcome this by enabling the simultaneous analysis of transcriptome proteome data within intact architecture tissues. In breast research, MDSP emerged as promising tool, revealing complex biological questions related to disease evolution, identifying biomarkers, discovering drug targets. review highlights potential revolutionize clinical applications, ranging from risk assessment diagnostics prognostics, patient monitoring, customization treatment strategies, including trial guidance. We discuss major techniques, applications integration practice, addressing both current limitations. Emphasizing strategic use stratification women with benign disease, we also highlight its transformative reshaping landscape research treatment.

Язык: Английский

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Neuronal mimicry in tumors: lessons from neuroscience to tackle cancer

Cancer and Metastasis Reviews, Год журнала: 2025, Номер 44(1)

Опубликована: Фев. 11, 2025

Язык: Английский

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Multiple anti-tumor programs are activated by blocking BAD phosphorylation

Oncogene, Год журнала: 2025, Номер unknown

Опубликована: Май 2, 2025

Язык: Английский

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