bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 1, 2024
ABSTRACT
Long-term
memories
are
consolidated
over
time,
progressively
becoming
more
stable
and
resistant
to
interference.
Memory
consolidation
occurs
offline
often
involves
transfer
of
from
one
brain
site
another.
For
many
motor
memories,
is
thought
involve
early
learning
in
cerebellar
cortex
that
subsequently
transferred
the
nuclei.
Here
we
report
mice,
engaging
locomotor
activity
during
training
a
classical
conditioning
task
shifts
critical
time
window
for
memory
consolidation,
just
after
sessions,
between
trials,
within
sessions.
This
temporal
shift
requires
natural
patterns
granule
cell
intertrial
intervals
accompanied
by
earlier
involvement
downstream
nucleus.
These
results
reveal
can
be
surprisingly
brief,
on
timescale
seconds
minutes,
it
dynamically
regulated
behavioral
state.
Science,
Год журнала:
2025,
Номер
387(6734), С. 682 - 688
Опубликована: Фев. 6, 2025
Fast
instinctive
responses
to
environmental
stimuli
can
be
crucial
for
survival
but
are
not
always
optimal.
Animals
adapt
their
behavior
and
suppress
reactions,
the
neural
pathways
mediating
such
ethologically
relevant
forms
of
learning
remain
unclear.
We
found
that
posterolateral
higher
visual
areas
(plHVAs)
escapes
from
innate
threats
through
a
top-down
pathway
ventrolateral
geniculate
nucleus
(vLGN).
plHVAs
no
longer
necessary
after
learning;
instead,
learned
relies
on
plasticity
within
vLGN
populations
exert
inhibitory
control
over
escape
responses.
neurons
receiving
input
enhance
threat
during
endocannabinoid-mediated
long-term
suppression
inputs.
thus
reveal
detailed
circuit,
cellular,
synaptic
mechanisms
underlying
experience-dependent
fear
Journal of Neuroscience,
Год журнала:
2024,
Номер
44(24), С. e0022242024 - e0022242024
Опубликована: Апрель 11, 2024
Memory
reactivation
during
sleep
is
thought
to
facilitate
memory
consolidation.
Most
research
has
examined
how
of
specific
facts,
objects,
and
associations
benefits
their
overall
retention.
However,
our
memories
are
not
unitary,
all
features
a
persist
in
tandem
over
time.
Instead,
transformed,
with
some
strengthened
others
weakened.
Does
drive
transformation?
We
leveraged
the
Targeted
Reactivation
technique
an
object
category
learning
paradigm
examine
this
question.
Participants
(20
female,
14
male)
learned
three
categories
novel
where
each
had
unique,
distinguishing
as
well
shared
other
members
its
category.
used
real-time
EEG
protocol
cue
these
objects
at
moments
optimized
generate
events.
found
that
improved
for
while
worsening
features,
suggesting
differentiation
process.
The
results
indicate
does
act
holistically
on
memories,
instead
supporting
transformation
enhanced
others.
Trends in Neurosciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Hippocampal
replay
is
widely
thought
to
support
two
key
cognitive
functions:
online
decision-making
and
offline
memory
consolidation.
In
this
review,
we
take
a
closer
look
at
the
hypothesized
link
between
awake
in
rodents,
find
only
marginal
evidence
of
role.
By
contrast,
consolidation
view
bolstered
by
new
computational
ideas
recent
data,
suggesting
that
(i)
performs
fictive
learning
for
later
goal-oriented
behavior;
(ii)
tags
memories
prior
sleep,
prioritizing
them
Based
on
these
advances,
favor
an
updated
refined
role
-
is,
supporting
prioritized
tagging
outside
hippocampus
rather
than
direct,
guiding
behavior.
Cell Reports,
Год журнала:
2025,
Номер
44(4), С. 115547 - 115547
Опубликована: Апрель 1, 2025
Neural
firing-rate
responses
to
sensory
stimuli
show
progressive
changes
both
within
and
across
sessions,
raising
the
question
of
how
brain
maintains
a
stable
code.
One
possibility
is
that
other
features
multi-neuron
spiking
patterns,
e.g.,
temporal
structure,
provide
coding
mechanism.
Here,
we
compared
spike-rate
spike-timing
codes
in
neural
ensembles
from
six
visual
areas
during
natural
video
presentations.
To
quantify
information
spike
sequences,
used
SpikeShip,
method
based
on
optimal
transport
theory
considers
relative
relations
among
all
neurons.
For
large
numbers
active
neurons,
sequences
conveyed
more
than
population
vectors.
Firing-rate
vectors
exhibited
substantial
drift
repetitions
between
blocks,
contrast
which
were
over
time.
These
findings
reveal
code
high-dimensional
ensembles.
