bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 17, 2024
Abstract
The
hippocampal
formation
is
central
for
the
learning
and
consolidation
of
spatial
memories.
While
it
known
that
high-frequency
oscillations,
called
sharp
wave
ripples,
play
a
critical
role
memory
processes,
unclear
if
they
interact
with
engram
cells.
Here
we
identify
effect
these
oscillations
on
cells
as
mice
explored
two
environments
over
several
days.
We
found
both
principal
interneurons
are
part
cfos-tagged
engram.
cells,
place
highly
reactivated
by
SWRs,
whereas
none
negatively
SWR-modulated
Together,
our
findings
reveal
link
between
cellular
network
mechanisms
imply
key
in
it.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 3, 2025
SUMMARY
Mental
exploration
enables
flexible
evaluation
of
potential
future
choices,
guiding
decision-making
without
requiring
direct
real-world
iterations.
Although
the
hippocampus
is
known
to
be
active
while
imagining
future,
precise
mechanisms
that
support
mental
choices
remain
unclear.
In
hippocampus,
theta
rhythm
(4-12
Hz)
prevalent
during
movement
and
supports
memory
coding
by
organizing
neuronal
activity
patterns
into
short
virtual
path
segments
(theta
sequences)
around
rat’s
location.
We
observed
these
theta-related
neural
in
a
hippocampus-dependent
working
task
also,
unexpectedly,
oscillations
immobility.
Compared
standard
sequences
movement,
immobility
differed
they
occurred
at
shifted
phase
preferentially
represented
remote
locations,
particular
next
choice
task.
Coding
for
locations
was
also
awake
sharp
wave
ripple,
but
short-lasting
events
rarely
were
biased
toward
frequently
visited
locations.
Therefore,
our
findings
suggest
recurring
bouts
immobility,
which
are
primates
humans,
cognitive
demands
hippocampal
network
facilitate
ongoing
predictions
choices.
Trends in Neurosciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Hippocampal
replay
is
widely
thought
to
support
two
key
cognitive
functions:
online
decision-making
and
offline
memory
consolidation.
In
this
review,
we
take
a
closer
look
at
the
hypothesized
link
between
awake
in
rodents,
find
only
marginal
evidence
of
role.
By
contrast,
consolidation
view
bolstered
by
new
computational
ideas
recent
data,
suggesting
that
(i)
performs
fictive
learning
for
later
goal-oriented
behavior;
(ii)
tags
memories
prior
sleep,
prioritizing
them
Based
on
these
advances,
favor
an
updated
refined
role
-
is,
supporting
prioritized
tagging
outside
hippocampus
rather
than
direct,
guiding
behavior.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 29, 2024
Summary
How
the
brain
reconciles
dynamism
with
stability
to
balance
learning
and
reliable
memory
storage
has
not
yet
been
fully
understood.
To
address
critical
question,
we
longitudinally
recorded
place
cells
in
hippocampal
dorsal
CA1
region
over
7
56
days,
utilizing
multiple
goal-oriented
navigation
paradigms
across
various
environments.
We
found
that
80%
of
displayed
fields,
undergoing
complex
evolution
events
including
field
disappearance,
formation,
retention.
Place
fields
from
same
neuron
showed
limited
coordination
(∼5%),
a
preference
for
synchronized
changes.
further
uncovered
single
rule:
longer
remains
active,
more
likely
it
is
continue
being
active;
conversely,
inactive,
less
recover
future
fate
depends
on
its
past
activity.
Mathematical
modeling
revealed
this
rule
sufficiently
demonstrates
growing
dCA1
spatial
representation
at
population
level.
