Protein‐Interference‐Free and Kidney‐Targeting NIR Fluorophores for Accurate in Vivo Imaging of H₂S₂ during Kidney Ferroptosis

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

High-fidelity kidney function imaging is important for assessing the nephrotoxicity of drugs and diagnosing renal diseases. However, current challenges in achieving accurate include unspecific signal enhancement due to albumin binding relatively low distribution agents kidneys. Here, first time, a side-chain engineering strategy that incorporates hydrophilic six-membered heterocycles into aza-hemicyanine generating high-performance with protein-interference-free kidney-targeting features proposed. Based on these unique dyes, albumin-insensitive H2S2 near-infrared (NIR) fluorescent probe NA-H2S2 designed, which demonstrates effective following intravenous injection specifically activated by H2S2. The designed presents highly rapid, selective sensitive response detection limit as 24.21 nm. Additionally, it successfully achieves real-time vivo NIR fluorescence during erastin/cisplatin induced ferroptosis. Moreover, also enables rapid through vitro optical urinalysis, offering significant diagnostic value Overall, this study not only practical increased accuracy but provides promising dyes further development disease-related probes.

Язык: Английский

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Ferroptosis spreads to neighboring cells via plasma membrane contacts

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Март 26, 2025

Abstract Ferroptosis is a lytic, iron-dependent form of regulated cell death characterized by excessive lipid peroxidation and associated with necrosis spread in diseased tissues through unknown mechanisms. Using novel optogenetic system for light-driven ferroptosis induction via degradation the anti-ferroptotic protein GPX4, we show that ferroptotic can to neighboring cells their closely adjacent plasma membranes. propagation dependent on distance completely abolished disruption α-catenin-dependent intercellular contacts or chelation extracellular iron. Remarkably, bridging bilayer increasing between enhances spread. Reconstitution pure lipid, contacting liposomes provides evidence physicochemical mechanism involved. Our findings support model which propagates across proximal membranes cells, thereby promoting transmission consequences pathological tissue

Язык: Английский

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OTULIN orchestrates NCOA4-FTH1 complex to alleviate APAP-induced hepatocyte Ferroptosis

International Immunopharmacology, Год журнала: 2025, Номер 154, С. 114490 - 114490

Опубликована: Март 31, 2025

Язык: Английский

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Targeting mitochondria-regulated ferroptosis: A new frontier in Parkinson’s Disease therapy

Neuropharmacology, Год журнала: 2025, Номер unknown, С. 110439 - 110439

Опубликована: Март 1, 2025

Язык: Английский

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Mechanisms of ferroptosis sensitization and resistance

Developmental Cell, Год журнала: 2025, Номер 60(7), С. 982 - 993

Опубликована: Апрель 1, 2025

Язык: Английский

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