Neuronal wiring diagram of an adult brain

Nature, Год журнала: 2024, Номер 634(8032), С. 124 - 138

Опубликована: Окт. 2, 2024

Язык: Английский

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The fly connectome reveals a path to the effectome

Nature, Год журнала: 2024, Номер 634(8032), С. 201 - 209

Опубликована: Окт. 2, 2024

Язык: Английский

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Statistical Mechanics of Directed Networks

Entropy, Год журнала: 2025, Номер 27(1), С. 86 - 86

Опубликована: Янв. 18, 2025

Directed networks are essential for representing complex systems, capturing the asymmetry of interactions in fields such as neuroscience, transportation, and social networks. Directionality reveals how influence, information, or resources flow within a network, fundamentally shaping behavior dynamical processes distinguishing directed from their undirected counterparts. Robust null models crucial identifying meaningful patterns these representations, yet designing that preserve key features remains significant challenge. One critical feature is reciprocity, which reflects balance bidirectional provides insights into underlying structural principles shape connectivity. This paper introduces statistical mechanics framework networks, modeling them ensembles interacting fermions. By controlling reciprocity other network properties, our formalism offers principled approach to analyzing structures dynamics, introducing new perspectives analytical tools empirical studies.

Язык: Английский

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Scale-free behavior of weight distributions of connectomes

Physical Review Research, Год журнала: 2025, Номер 7(1)

Опубликована: Фев. 5, 2025

To determine the precise link between anatomical structure and function, brain studies primarily concentrate on wiring of its topological properties. In this work, we investigate weighted degree connection length distributions KKI-113 KKI-18 human connectomes, fruit fly, mouse retina. We find that node strength (weighted degree) distribution behavior differs depending considered scale. On global scale, are found to follow a power-law behavior, with roughly universal exponent close 3. However, breaks at local scale as stretched exponential, fly retina log-normal distribution, respectively, which indicative underlying random multiplicative processes underpins nonlocality learning in critical state. for case H01 (1mm3) datasets, an exponentially truncated power law, may hint fact mechanism have manifested level too. Published by American Physical Society 2025

Язык: Английский

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Synaptic connectome of a neurosecretory network in the Drosophila brain

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 29, 2024

Abstract Hormones mediate inter-organ signaling which is crucial in orchestrating diverse behaviors and physiological processes including sleep activity, feeding, growth, metabolism reproduction. The pars intercerebralis lateralis insects represent major hubs contain neurosecretory cells (NSC) that produce various hormones. To obtain insight into how hormonal regulated, we have characterized the synaptic connectome of NSC adult Drosophila brain. Identification neurons providing inputs to multiple subtypes implicates diuretic hormone 44-expressing as a coordinator physiology behavior. Surprisingly, despite most having dendrites subesophageal zone (primary taste processing center), gustatory are largely indirect. We also deciphered pathways via olfactory relayed NSC. Further, our analyses revealed substantial from descending NSC, suggesting regulate both endocrine motor output synchronize changes with appropriate behaviors. In contrast inputs, sparse mostly mediated by corazonin Therefore, additionally determine putative paracrine interconnectivity between peripheral tissues analyzing single-cell transcriptomic datasets. Our comprehensive characterization network provides platform understand complex networks they orchestrate animal physiology.

Язык: Английский

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Evolution of neural circuitry and cognition

Biology Letters, Год журнала: 2024, Номер 20(5)

Опубликована: Май 1, 2024

Neural circuits govern the interface between external environment, internal cues and outwardly directed behaviours. To process multiple environmental stimuli integrate these with state requires considerable neural computation. Expansion in network size, most readily represented by whole brain has historically been linked to behavioural complexity, or predominance of cognitive Yet, it is largely unclear which aspects circuit variation impact performance. A key question field evolutionary neurobiology therefore how evolve allow improved performance innovation. We discuss this first exploring volumetric changes areas reflect actual change. explore three major axes evolution-replication, restructuring reconditioning cells circuits-and could relate broader phenotypes variation. This discussion touches on relevant uses limitations volumetrics, while advocating a more circuit-based view cognition. then use framework showcase an example from insect brain, multi-sensory integration processing that shared mushroom bodies central complex. end identifying future trends research area, promise advance neurobiology.

Язык: Английский

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Activity of a descending neuron associated with visually elicited flight saccades in Drosophila

Current Biology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Highlights•The descending neuron DNp03 in Drosophila responds to aversive looming stimuli•Its spiking activity is state dependent and correlated with flight saccades•DNp03 provides input other neurons involved controlling turns•Optogenetic activation of can initiate free-flight saccadesSummaryApproaching threats are perceived through visual looming, a rapid expansion an image on the retina. Visual triggers defensive responses such as freezing, flight, turning, or take-off wide variety organisms, from mice fish insects.1,2,3,4 In response flies perform evasive turns known saccades.5 Saccades also be initiated spontaneously change direction during flight.6,7,8,9 Two types (DNs), DNaX DNb01, were previously shown exhibit both spontaneous looming-elicited saccades Drosophila.10,11 As they do not receive direct system, it has remained unclear how visually elicited controlled by nervous system. receives looming-sensitive projection output wing motor neurons12,13 therefore promising candidate for saccades. Using whole-cell patch-clamp recordings head-fixed flying Drosophila, we showed that ipsilateral behavioral-state-dependent manner. We further explored relates variable behavioral output. Sustained activity, persisting after stimulus, was strongest predictor saccade execution. However, alone cannot fully explain variability responses. Combined optogenetic experiments free these results suggest important but exclusive role saccades, advancing our understanding information transformed into commands maneuvers insects.Graphical abstract

Язык: Английский

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Connectomic analysis of taste circuits in Drosophila

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 12, 2025

Abstract Our sense of taste is critical for regulating food consumption. The fruit fly Drosophila represents a highly tractable model to investigate mechanisms processing, but circuits beyond sensory neurons are largely unidentified. Here, we use whole-brain connectome the organization circuits. We trace pathways from four populations that detect different modalities and project subesophageal zone (SEZ), primary region brain. find second-order primarily located within SEZ segregated by modality, whereas third-order have more projections outside overlap between modalities. Taste out innervate regions implicated in feeding, olfactory learning. analyze interconnections pathways, characterize modality-dependent differences neuron properties, identify other types inputs onto computational simulations relate neuronal connectivity predicted activity. These studies provide insight into architecture

Язык: Английский

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LRRK2 in Drosophila Melanogaster Model: Insights into Cellular Dysfunction and Neuroinflammation in Parkinson’s Disease

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2093 - 2093

Опубликована: Фев. 27, 2025

Parkinson's disease (PD) is a fatal neurodegenerative for which there are no still effective treatments able to stop or slow down neurodegeneration. To date, pathological mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified as major genetic cause of PD, although molecular mechanism responsible loss dopaminergic neurons cryptic. In this review, we explore contribution Drosophila models elucidation LRRK2 function different cellular pathways either glial cells. Importantly, recent studies shown that highly expressed immunocompetent cells, including astrocytes and microglia brain, compared neuronal expression. also strongly associated with development inflammatory diseases production molecules. Using models, paper shows reduction response protects flies from neurodegeneration induced by mutant

Язык: Английский

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Network Structure Governs Drosophila Brain Functionality

Fundamental Research, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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