Obesity Pillars, Год журнала: 2025, Номер unknown, С. 100175 - 100175
Опубликована: Апрель 1, 2025
Язык: Английский
American Journal of Transplantation, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Янв. 22, 2025
People frequently experience cycles of weight gain and loss. This cycling has been demonstrated, in humans animal models, to increase cardiometabolic disease disrupt glucose homeostasis. Obesity itself - an even greater extent regain causes adipose tissue inflammation, resulting metabolic dysfunction. Studies show that after loss, increased numbers lipid associated macrophages memory T cells persist become more inflammatory upon regain. These findings suggest the immune system retains a "memory" obesity, which may contribute elevated inflammation dysfunction with cycling. Here, we blocking CD70-CD27 axis, critical for formation immunological memory, decreases number reduces cell clonality within loss Furthermore, while mice impaired ability create obesogenic have similar responses as wildtype stable they are protected from worsened tolerance Our data first target consequences through immunomodulatory mechanism. Thus, propose new avenue therapeutic intervention by targeting can be leveraged minimize adverse particularly timely given increasing use efficacious drugs, will likely lead instances human
Язык: Английский
Процитировано
0
Nutrients, Год журнала: 2025, Номер 17(3), С. 413 - 413
Опубликована: Янв. 23, 2025
Background: Metabolic syndrome (MetS) patients have impaired hypothalamic regulatory functions involved in food intake and energy expenditure suffer from a state of meta-inflammation. Pre-clinical studies demonstrated that ultramicronized palmitoylethanolamide (PEA) acts both on the adipose tissue central nervous system, while hydroxytyrosol (HTyr) counteracts several types dysmetabolism. Objectives: The aim our randomized crossover double-blind placebo-controlled pilot study was to evaluate potential effects supplement (FS) containing co-micronized formulation PEA rutin along with HTyr, combined tailored calorie-controlled Mediterranean diet, MetS. Methods: Nineteen were enrolled block-randomized an eight-week MD together FS or placebo. After two-week washout period, treatments reversed. Data laboratory parameters those detected by capillary sampling, anthropometry, body composition analysis, ultrasound examination, blood pressure monitoring, 36-Item Short-Form Health Survey questionnaire, handgrip strength test, physical performance tests collected at each time point (protocol code R.S. 262.22, registered 20 December 2022). Results: At end study, supplemented showed significant reduction weight, mass index, fat mass, inflammation biomarkers (CRP ESR), compared placebo-supplemented patients. In contrast, fat-free phase angle, cell increased placebo Conclusions: Although preliminary, results clinical suggest PEA–rutin HTyr may be help against adiposopathy
Язык: Английский
Процитировано
0
Acta Pharmaceutica Sinica B, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Cahiers de Nutrition et de Diététique, Год журнала: 2025, Номер 60(1), С. 1 - 2
Опубликована: Фев. 1, 2025
Процитировано
0
Nutrients, Год журнала: 2025, Номер 17(5), С. 827 - 827
Опубликована: Фев. 27, 2025
Milk is the principal nutrient of newborn humans and a diagnostic feature order Mammalia. Its release elicited as reflex by infant sucking under control hormone oxytocin. While it recognized that breast milk optimally promotes longitudinal growth development, this review explores facts controversies regarding extent to which milks several dairy animals formula (IF) approximate special properties bioactivities milk. It also provides evidence early exposure undernutrition during very rapid fetal infancy predominantly permanently stunts trajectory in both often followed later life obesity metabolic dysfunction, sometimes precocious timing sexual maturation. There knowledge gap whether there may be additional critical periods nutritional vulnerability human characterized relatively prolonged period slow childhood bracketed fetal-neonatal pubertal spurts. unclear any quantitative differences caloric intake supply neonatal influence developmental fatness programming. A further exists role microbiome composition development possible epigenetic programming or life. Extending research entire from conception end puberty, examining factors modulating favor obesity, gut developing infant's capacity process nutrients provide better understanding interaction between influences later-life obesity.
Язык: Английский
Процитировано
0
Epigenomics, Год журнала: 2025, Номер unknown, С. 1 - 12
Опубликована: Март 2, 2025
Dietary modification is a cornerstone and primary goal for weight loss, whose effects may be related to epigenetic phenomena. In this literature review, comprehensive search without time restriction was performed in PubMed/Medline, Cochrane, SciELO, Scopus databases identify signatures obesity outcomes upon dietary advice. context, experimental studies clinical trials have identified certain DNA methylation marks, miRNA expression profiles histone modifications putatively associated with adiposity after different nutritional interventions. These include traditional patterns, diets macronutrient compositions, supplementation fatty acids, amino acids derivatives, methyl donors, vitamins minerals, probiotics prebiotics, bioactive food compounds. Some of these been mapped genes involved intake control, adipogenesis, lipolysis, acid oxidation, body fat deposition, gut microbiota modulation. However, additional are still required address dosage follow-up variability, validation genome-wide approaches, appropriate statistical settings. Although more investigation required, insights contribute the characterization biomarkers regulation toward prescription tailored strategies targeting epigenome precise management control.
Язык: Английский
Процитировано
0
Trends in Endocrinology and Metabolism, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Fasting is a recurrent daily energy stress that benefits healthspan and lifespan. While ketones fuel fasting in vertebrates, the underlying transcriptional mechanism remains incompletely understood. Recently, Korenfeld et al. revealed peroxisome proliferator-activated receptor alpha (PPARα)-dependent enhancer priming as keystone for ketone production, increasing our understanding of mechanisms metabolic alternate-day (ADF).
Язык: Английский
Процитировано
0
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Март 11, 2025
Abstract Adaptive thermogenesis, or beiging, involves the conversion of energy-storing white adipocytes into energy-dissipating beige adipocytes, enabling physiological adaptation to environmental stressors such as hypothermia. While and share transcriptional similarity, this identity switch still requires epigenetic reprogramming. However, molecular mechanisms governing transition remain incompletely understood. Here, we identify SUMOylation a critical repressor adipocyte beiging. Using small-molecule inhibitor TAK-981, demonstrate that transient inhibition primes human express beiging genes including UCP1 inducing mitochondrial uncoupling in rosiglitazone-dependent manner. Furthermore, suppresses both de novo differentiation adipose stem cells transdifferentiation mature cells. Mechanistically, TAK-981 modulates cAMP-PKA-p38 signaling axis, ultimately affecting downstream programs under control PPARG PPARA enhancers. Our findings establish fundamental barrier white-to-beige reprogramming suggest pharmacological combination agonists with can promote metabolically beneficial tissue remodeling clinical settings.
Язык: Английский
Процитировано
0
Gynecological Endocrinology, Год журнала: 2025, Номер 41(1)
Опубликована: Март 20, 2025
Язык: Английский
Процитировано
0