Memory engram stability and flexibility
Neuropsychopharmacology,
Год журнала:
2024,
Номер
50(1), С. 285 - 293
Опубликована: Сен. 18, 2024
Язык: Английский
Hippocampal Ripple Diversity organises Neuronal Reactivation Dynamics in the Offline Brain
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Март 12, 2025
Summary
Hippocampal
ripples
are
highly
synchronized
neuronal
population
patterns
reactivating
past
waking
experiences
in
the
offline
brain.
Whether
level,
structure,
and
content
of
ripple-nested
activity
consistent
across
consecutive
events
or
tuned
each
event
remains
unclear.
By
profiling
individual
using
laminar
currents
mouse
hippocampus
during
sleep/rest,
we
identified
Rad
sink
LM
featuring
current
sinks
stratum
radiatum
versus
lacunosum-moleculare
,
respectively.
These
two
ripple
profiles
recruit
neurons
differently.
integrate
recent
motifs
coactivity,
combining
superficial
deep
CA1
principal
cells
into
denser,
higher-dimensional
that
undergo
hour-long
stable
reactivation.
In
contrast,
contain
core
prior
engaging
sparser,
lower-dimensional
a
reactivation
drift,
gradually
updating
their
pre-structured
for
wakefulness.
We
propose
ripple-by-ripple
diversity
instantiates
parallel
channels
integration
wakefulness
flexible
internal
representations.
Язык: Английский
Experience reorganizes content-specific memory traces in macaques
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 14, 2025
Abstract
Memory
formation
requires
neural
activity
reorganization
during
experience
that
persists
in
sleep.
How
these
processes
promote
learning
while
preserving
established
memories
remains
unclear.
We
recorded
ensemble
from
hippocampal
and
associated
regions
freely
moving
macaques
as
they
recalled
item
sequences
presented
day
(“new”),
one
prior
(“recent”),
or
over
two
weeks
(“old”).
Cell
assemblies
biased
for
old
showed
less
drift,
greater
network
connectivity,
stronger
sleep
reactivation
than
new-biased
assemblies.
Pairs
of
recent
formed
persistent
task-to-sleep
coupling
(“metassemblies”),
unlike
new
assembly
pairs.
In
the
hippocampus,
propensity
superficial
deep
CA1
pyramidal
cells
to
form
integrated
increased
with
memory
age.
These
findings
reveal
rapid
organization
stabilization
primate
brain,
suggesting
potential
mechanisms
balancing
linking
durability.
Язык: Английский
Aversive memory engrams in the hippocampus
Brain Organoid and Systems Neuroscience Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Stress warps fear memories in multiple ways
The Transmitter,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Chemotagging: a chemogenetic approach for identifying cell types with in vivo calcium imaging
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 27, 2024
Abstract
The
ability
to
monitor
the
activity
of
specific
cell
types
in
vivo
is
critical
for
understanding
complex
interplay
between
various
neuronal
populations
driving
freely
moving
behavior.
Existing
methods,
such
as
optogenetic
tagging
(i.e.,
Optotagging
1
),
have
proven
useful
identifying
electrophysiological
recordings
during
However,
are
limited
their
capacity
track
same
across
long
periods
time
(days
weeks).
Single-photon
miniscope
imaging
offers
advantage
tracking
cells
weeks
months;
however,
it
difficult
distinguish
different
within
recorded
population.
Here,
we
present
“chemotagging,”
a
technique
that
allows
identification
calcium
recordings.
This
protocol
method
with
chemogenetic
tools
like
Designer
Receptors
Exclusively
Activated
by
Drugs
(DREADDs)
2
,
while
simultaneously
recording
from
pan-neuronal
population
indicators.
We
highlight
key
advantages
and
limitations
chemotagging
its
potential
implications
neuroscience
research.
Язык: Английский
cfos principal cells and interneurons are strongly reactivated by sharp wave ripples
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 17, 2024
Abstract
The
hippocampal
formation
is
central
for
the
learning
and
consolidation
of
spatial
memories.
While
it
known
that
high-frequency
oscillations,
called
sharp
wave
ripples,
play
a
critical
role
memory
processes,
unclear
if
they
interact
with
engram
cells.
Here
we
identify
effect
these
oscillations
on
cells
as
mice
explored
two
environments
over
several
days.
We
found
both
principal
interneurons
are
part
cfos-tagged
engram.
cells,
place
highly
reactivated
by
SWRs,
whereas
none
negatively
SWR-modulated
Together,
our
findings
reveal
link
between
cellular
network
mechanisms
imply
key
in
it.
Язык: Английский