Aging activates escape of the silent X chromosome in the female mouse hippocampus

Science Advances, Год журнала: 2025, Номер 11(10)

Опубликована: Март 5, 2025

Women live longer than men and exhibit less cognitive aging. The X chromosome contributes to sex differences, as females harbor an inactive (Xi) active (Xa), in contrast males with only Xa. Thus, reactivation of silent Xi genes may contribute differences. We use allele-specific, single-nucleus RNA sequencing show that aging remodels transcription the Xa across hippocampal cell types. Aging preferentially changed gene expression on X's relative autosomes. Select underwent activation, new escape cells including dentate gyrus, critical learning memory. Expression escapee Plp1, a myelin component, was increased hippocampus female mice parahippocampus women. AAV-mediated Plp1 elevation gyrus male improved cognition. Understanding how confer advantage could lead novel targets counter brain disease both sexes.

Язык: Английский

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X chromosome passed from mother to daughter influences brain ageing

Nature, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Язык: Английский

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Strategies for studying sex differences in brain aging

Trends in Genetics, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Why women experience Alzheimer’s disease differently from men

Nature, Год журнала: 2025, Номер 640(8059), С. S14 - S17

Опубликована: Апрель 16, 2025

Язык: Английский

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