Cigarette smoking induces lung cancer tumorigenesis via upregulation of the WNT/β-catenin signaling pathway

Life Sciences, Год журнала: 2023, Номер 326, С. 121787 - 121787

Опубликована: Май 19, 2023

Язык: Английский

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Lung cancer in never smokers: Tumor immunology and challenges for immunotherapy

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Авг. 24, 2022

Lung cancer is the second most common and lethal malignancy worldwide. It estimated that lung in never smokers (LCINS) accounts for 10-25% of cases, its incidence increasing according to recent data, although reasons remain unclear. If considered alone, LCINS 7th cause death. These tumors occur more commonly younger patients females. tend have a better prognosis, possibly due higher chance bearing an actionable driver mutation, making them amenable targeted therapy. Notwithstanding, these respond poorly immune checkpoint inhibitors (ICI). There are several putative explanations poor response immunotherapy: low immunogenicity tumor mutation burden hence MANA (mutation-associated neo-antigen) load, constitutive PD-L1 expression mutated protein signaling, high immunosuppressive factors by cells (like CD39 TGF-beta), non-permissive TME (tumor microenvironment), abnormal metabolism amino acids glucose, impaired TLS (Tertiary Lymphoid Structures) organization. Finally, there concern offering ICI as first line therapy owing reports severe toxicity when TKIs (tyrosine kinase inhibitors) administered sequentially after ICI. Understanding biology behind against crucial development therapeutic strategies.

Язык: Английский

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Genetic differences between smokers and never-smokers with lung cancer

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Фев. 2, 2023

Smoking is a major risk factor for lung cancer, therefore cancer epidemiological trends reflect the past of cigarette smoking to great extent. The geographic patterns in mortality closely follow those incidence. Although strongly associated with smoking, only about 15% smokers get and also some never-smokers develop this malignancy. less frequent, never seventh leading cause deaths both sexes worldwide. Lung differs many aspects: histological types, environmental factors representing risk, genes disease. In review, we will focus on genetic differences between versus never-smokers: gene expression, germ-line polymorphisms, mutations, as well ethnic gender differences. Finally, treatment options be briefly reviewed.

Язык: Английский

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Gender Differences in Oxidative Stress in Relation to Cancer Susceptibility and Survival

Опубликована: Май 10, 2023

Genetic, developmental, biochemical, and environmental variables interact intricately to produce sex differences. The significance of differences in cancer susceptibility is being clarified by numerous studies. Epidemiological research registries have revealed over the past few years that there are definite variations incidence, progression, survival. However, oxidative stress mitochondrial dysfunction also a significant impact on response treatment neoplastic diseases. Young women may be more protected from than men because most proteins implicated regulation redox state function under control sexual hormones. In this review, we describe how hormones activity antioxidant enzymes mitochondria, as well they affect several molecular pathways underlie gender-related discrepancies been identified better understood, which lead effective precision medicine vital information options for both males females with illnesses.

Язык: Английский

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Lung Cancer in Never Smokers: Delving into Epidemiology, Genomic and Immune Landscape, Prognosis, Treatment, and Screening

Lung, Год журнала: 2023, Номер 201(6), С. 521 - 529

Опубликована: Ноя. 16, 2023

Язык: Английский

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