Therapeutic Reprogramming toward Regenerative Medicine

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Therapeutic reprogramming represents a transformative paradigm in regenerative medicine, developing new approaches cell therapy, small molecule drugs, biologics, and gene therapy to address unmet medical challenges. This encompasses the precise modulation of cellular fate function either generate safe functional cells ex vivo for cell-based therapies or directly reprogram endogenous situ tissue repair regeneration. Building on discovery induced pluripotent stem (iPSCs), advancements chemical CRISPR-based editing have propelled iterative medicine paradigm, focusing scalable, standardized products from universal starting materials enabling improvements more effective therapeutic profiles. Beyond therapies, non-cell-based strategies targeting may offer less invasive, convenient, accessible, cost-effective alternative treating broad range diseases, potentially rejuvenating tissues extending healthspan.

Язык: Английский

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Improving chemical reprogramming strategies

Nature Reviews Molecular Cell Biology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 17, 2025

Язык: Английский

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Decoding human chemical reprogramming: mechanisms and principles

Trends in Biochemical Sciences, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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A speedy cocktail

Nature Chemical Biology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 3, 2025

Язык: Английский

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Chemical-based epigenetic reprogramming to advance pluripotency and totipotency

Nature Chemical Biology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 18, 2025

Язык: Английский

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