Nature Immunology, Год журнала: 2024, Номер unknown
Опубликована: Окт. 4, 2024
Язык: Английский
Journal of Microbiology Immunology and Infection, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Respiratory virus infection is an important cause of both community acquired pneumonia and hospital-acquired pneumonia. Various respiratory viruses, including influenza virus, avian syncytial (RSV), SARS-CoV, MERS-CoV, SARS-CoV-2, result in severe fibrosis sequelae after the acute phase. Since COVID-19 pandemic, infection, as pulmonary fibrosis, has attracted increasing attention around world. usually triggers robust inflammation responses, leading to large amounts proinflammatory mediator production, such chemokine (C-C motif) ligand 2 (CCL2), a critical involved recruitment various inflammatory cells. Moreover, CCL2 plays pivotal role pathogenesis progression, through regulating bone marrow-derived monocytes expression extracellular matrix proteins. This review provided concise overview common infection. Then we discussed elevated levels underscoring its potent profibrotic role. Targeting CCL2/CCR2 axis holds promise for alleviating post-acute warrants further investigation.
Язык: Английский
Процитировано
0
Deleted Journal, Год журнала: 2025, Номер 3(1), С. 10004 - 10004
Опубликована: Янв. 1, 2025
Idiopathic pulmonary fibrosis (IPF) is marked by progressive alveolar destruction, impaired tissue regeneration, and relentless fibrogenesis, culminating in respiratory failure death. A diverse array of resident non-resident cells within the lung contribute to disease pathogenesis. Notably, immune cells, both recruited, respond cues from sites injury undergoing phenotypic transitions producing a wide range mediators that influence, initiate, or dictate function, dysfunction, key effector IPF pathology, such as epithelial fibroblasts, capillary endothelial cells. The role system has undergone an interesting evolution, oscillating initial enthusiasm skepticism, now renewed focus. This shift reflects past failures immune-targeting therapies for unprecedented insights into cell heterogeneity provided emerging technologies. In this article, we review historical evolution perspectives on system's pathogenesis examine lessons learned previous therapeutic targeting responses. We discuss major types implicated progression, highlighting their mechanisms action. Finally, identify knowledge gaps propose future directions research IPF.
Язык: Английский
Процитировано
0
Nature Immunology, Год журнала: 2025, Номер unknown
Опубликована: Март 26, 2025
Язык: Английский
Процитировано
0
Current Opinion in Lipidology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 3, 2025
Purpose of review As the primary guardians at air-surface interface, functional profile alveolar macrophages (AM) is wide-ranging from establishment niche, homeostatic maintenance surfactant levels, to pathogen clearance and resolution repair processes. Alveolar lipid homeostasis disturbed in chronic lung diseases contributes disease pathogenesis through extracellular localization lumen or intracellular accumulation AM. This aims provide a focused overview state knowledge AM, their ontogeny development during health disease, how dysregulated AM lipids play key role processes, initiation resolution. Recent findings While lipid-laden are observed across broad spectrum diseases, occurrence has largely been considered consequential. advances lipidomic profiling single cell types revealed that disturbances occur early tissue-resident cells. Comparisons between inflammatory fibrotic injury models reveal specific macrophage subsets with different utilization contribute process. Summary Understanding intricate web population seeding this niche perturbed by may help leverage for new interventions.
Язык: Английский
Процитировано
0
Опубликована: Апрель 18, 2025
Abstract We developed Standardised Minimum 3D Distance (SM3DD), an entirely cell segmentation/annotation-free approach to the analysis of spatial RNA datasets, using it compare lung tissue from 16 clinically normal individuals those 18 SARS-CoV-2 patients who died acute respiratory distress syndrome. coordinates were determined CosMx™ Spatial Molecular Imager (Bruker Biology, US). For each individual transcript location, we calculated three-dimensional distances nearest type, standardising type. Mean SM3DDs compared between and patients. Notably, hierarchical clustering directional log10(P) values organized genes by functionality, making easier interpret biological contexts for FKBP11, where a decrease in distance MZT2A was most significant difference, suggesting role interferon signaling. Using segmented principal components entire SM3DD dataset, identified multiple pathways, including ‘SARS-CoV-2 infection’, even though assay did not include any transcripts.
Язык: Английский
Процитировано
0
Pathogens, Год журнала: 2024, Номер 13(12), С. 1109 - 1109
Опубликована: Дек. 15, 2024
Antibody-dependent enhancement (ADE) is a phenomenon in which antibodies enhance subsequent viral infections rather than preventing them. Sub-optimal levels of neutralizing individuals infected with dengue virus are known to be associated severe disease upon reinfection different serotype. For Severe Acute Respiratory Syndrome Coronavirus type-2 infection, three types ADE have been proposed: (1) Fc receptor-dependent infection cells expressing receptors, such as macrophages by anti-spike antibodies, (2) receptor-independent epithelial and (3) cytokine production anti-nucleocapsid antibodies. This review focuses on the induced examining its potential role COVID-19 during contribution post-acute sequelae COVID-19, i.e., prolonged symptoms lasting at least months after acute phase disease. We also discuss protective effects recently identified that neutralize Omicron variants.
Язык: Английский
Процитировано
2
Nature Immunology, Год журнала: 2024, Номер unknown
Опубликована: Окт. 4, 2024
Язык: Английский
Процитировано
0