Tumor Microenvironment Lactate: Is It a Cancer Progression Marker, Immunosuppressant, and Therapeutic Target? DOI Creative Commons
Eugene Y. Kim,

Joyce Abides,

Chandler R. Keller

и другие.

Molecules, Год журнала: 2025, Номер 30(8), С. 1763 - 1763

Опубликована: Апрель 15, 2025

The “Warburg effect” is a term coined century ago for the preferential use of glycolysis over aerobic respiration in tumor cells energy production, even under conditions. Although this less efficient mechanism generating from glucose, glycolysis, addition to canonical anaerobic an effective means lactate production. abundant waste product, lactate, yielded by dual tumor, has been discovered be major biomolecule that drives cancer progression. Lactate metabolic source that, via cell membrane transporters, shuttles and out as well cell-associated stromal immune within microenvironment (TME). Additionally, serves pH tuner, signaling ligand transducer, epigenetic gene transcription regulator, TME modifier, suppressor, chemoresistance modulator, prognostic marker. With such broad functionalities, production–consumption–reproduction fuels growth dissemination. Here, we elaborate on sources contribute pool TME, functions influence function local tissue immunity, anticancer therapeutic approaches adopting manipulations their efficacies. By scrutinizing these properties others have addressed field, it expected better weighing development, progression, prognosis, efficacy can achieved.

Язык: Английский

Tumor Microenvironment Lactate: Is It a Cancer Progression Marker, Immunosuppressant, and Therapeutic Target? DOI Creative Commons
Eugene Y. Kim,

Joyce Abides,

Chandler R. Keller

и другие.

Molecules, Год журнала: 2025, Номер 30(8), С. 1763 - 1763

Опубликована: Апрель 15, 2025

The “Warburg effect” is a term coined century ago for the preferential use of glycolysis over aerobic respiration in tumor cells energy production, even under conditions. Although this less efficient mechanism generating from glucose, glycolysis, addition to canonical anaerobic an effective means lactate production. abundant waste product, lactate, yielded by dual tumor, has been discovered be major biomolecule that drives cancer progression. Lactate metabolic source that, via cell membrane transporters, shuttles and out as well cell-associated stromal immune within microenvironment (TME). Additionally, serves pH tuner, signaling ligand transducer, epigenetic gene transcription regulator, TME modifier, suppressor, chemoresistance modulator, prognostic marker. With such broad functionalities, production–consumption–reproduction fuels growth dissemination. Here, we elaborate on sources contribute pool TME, functions influence function local tissue immunity, anticancer therapeutic approaches adopting manipulations their efficacies. By scrutinizing these properties others have addressed field, it expected better weighing development, progression, prognosis, efficacy can achieved.

Язык: Английский

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