Why does COVID-19 disproportionately affect older people?

Aging, Год журнала: 2020, Номер 12(10), С. 9959 - 9981

Опубликована: Май 29, 2020

The severity and outcome of coronavirus disease 2019 (COVID-19) largely depends on a patient's age. Adults over 65 years age represent 80% hospitalizations have 23-fold greater risk death than those under 65. In the clinic, COVID-19 patients most commonly present with fever, cough dyspnea, from there can progress to acute respiratory distress syndrome, lung consolidation, cytokine release endotheliitis, coagulopathy, multiple organ failure death. Comorbidities such as cardiovascular disease, diabetes obesity increase chances fatal but they alone do not explain why is an independent factor. Here, we molecular differences between young, middle-aged older people that may mild illness in some life-threatening others. We also discuss several biological clocks could be used conjunction genetic tests identify both mechanisms individuals at risk. Finally, based these mechanisms, treatments survival people, simply by inhibiting virus, restoring patients' ability clear infection effectively regulate immune responses.

Язык: Английский

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Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

Nature Metabolism, Год журнала: 2020, Номер 2(10), С. 1135 - 1148

Опубликована: Окт. 16, 2020

Язык: Английский

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DunedinPACE, a DNA methylation biomarker of the pace of aging

eLife, Год журнала: 2022, Номер 11

Опубликована: Янв. 14, 2022

Measures to quantify changes in the pace of biological aging response intervention are needed evaluate geroprotective interventions for humans. Previously, we showed that quantification from a DNA-methylation blood test was possible (Belsky et al., 2020). Here, report next-generation biomarker Pace Aging, DunedinPACE (for Aging Calculated Epigenome).

Язык: Английский

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Ageing hallmarks exhibit organ-specific temporal signatures

Nature, Год журнала: 2020, Номер 583(7817), С. 596 - 602

Опубликована: Июль 15, 2020

Язык: Английский

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Individual variation of the SARS‐CoV‐2 receptor ACE2 gene expression and regulation

Aging Cell, Год журнала: 2020, Номер 19(7)

Опубликована: Июнь 19, 2020

The COVID-19 coronavirus is now spreading worldwide. Its pathogen, SARS-CoV-2, has been shown to use angiotensin-converting enzyme 2 (ACE2) as its host cell receptor, same the severe acute respiratory syndrome (SARS-CoV) in 2003. Epidemiology studies found males although only slightly more likely be infected than females account for majority of severely ill and fatality, which also bias people older 60 years or with metabolic cardiovascular diseases. Here by analyzing GTEx other public data 30 tissues across thousands individuals, we a significantly higher level Asian females, an age-dependent decrease all ethnic groups, highly significant type II diabetic patients ACE2 expression. Consistently, most expression quantitative loci (eQTLs) contributing high are close 100% East Asians, >30% groups. A shockingly common enrichment viral infection pathways was among anti-expressed genes, multiple binding sites virus related transcription factors sex hormone receptors locate at regulatory regions. Human mice analysis further revealed reduced T2D inflammatory cytokine treatment upregulated estrogen androgen (both age). Our findings negative correlation between fatality both population molecular levels. These results will instrumental when designing potential prevention strategies coronaviruses general.

Язык: Английский

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An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging

Nature Aging, Год журнала: 2021, Номер 1(7), С. 598 - 615

Опубликована: Июль 12, 2021

Язык: Английский

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Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?

Ageing Research Reviews, Год журнала: 2021, Номер 71, С. 101422 - 101422

Опубликована: Авг. 13, 2021

Язык: Английский

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Genetics meets proteomics: perspectives for large population-based studies

Nature Reviews Genetics, Год журнала: 2020, Номер 22(1), С. 19 - 37

Опубликована: Авг. 28, 2020

Язык: Английский

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Measuring biological age using omics data

Nature Reviews Genetics, Год журнала: 2022, Номер 23(12), С. 715 - 727

Опубликована: Июнь 17, 2022

Язык: Английский

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The aging lung: Physiology, disease, and immunity

Cell, Год журнала: 2021, Номер 184(8), С. 1990 - 2019

Опубликована: Апрель 1, 2021

Язык: Английский

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