Clinica Chimica Acta, Год журнала: 2024, Номер unknown, С. 120104 - 120104
Опубликована: Дек. 1, 2024
Язык: Английский
The Lancet, Год журнала: 2024, Номер 404(10448), С. 158 - 174
Опубликована: Июнь 20, 2024
Язык: Английский
Процитировано
40
Diabetology & Metabolic Syndrome, Год журнала: 2025, Номер 17(1)
Опубликована: Янв. 20, 2025
Язык: Английский
Процитировано
1
Placenta, Год журнала: 2025, Номер 164, С. 10 - 20
Опубликована: Март 12, 2025
Язык: Английский
Процитировано
0
Journal of Nutrition, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Advances in Clinical Medicine, Год журнала: 2025, Номер 15(04), С. 2255 - 2261
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Nutrients, Год журнала: 2025, Номер 17(9), С. 1519 - 1519
Опубликована: Апрель 30, 2025
During pregnancy, the maternal body adapts in several ways to create an optimal environment for embryonic growth. These changes include endocrine and metabolic shifts that can lead insulin resistance gestational diabetes mellitus (GDM), impacting both mother fetus short long term. Fetal macrosomia, a condition where is significantly larger than average, primary concern associated with GDM. Although underlying mechanism remains unclear, pregnancy-induced proinflammatory state, combined altered glucose homeostasis, plays critical role. Several cytokines hormones, such as interleukin 6 (IL-6), growth factor 1 (IGF-1), prolactin (PRL), or progesterone, are essential fetal growth, control of inflammatory response, regulation lipid carbohydrate metabolism meet energy demands during pregnancy. However, although role these adulthood has been extensively studied, their implication pathophysiology GDM macrosomia not well understood. Here, we review this pose hypothesis aberrant response cytokine receptor activation, particularly involving suppressor signaling 2 (SOCS2), contributes macrosomia. This novel perspective suggests unexplored by which SOCS2 dysregulation could impact pregnancy outcomes.
Язык: Английский
Процитировано
0
Frontiers in Endocrinology, Год журнала: 2025, Номер 16
Опубликована: Май 16, 2025
Gestational diabetes mellitus (GDM) is one of the most common endocrine-related complications during pregnancy, and its prevalence has increased over past three decades. GDM adversely affects maternal cardiovascular system, umbilical-placental blood perfusion, fetal flow. We conducted a comprehensive literature search systematically evaluated synthesized changes in mothers, circulation, progeny following exposure to GDM. Multiple pathophysiological mechanisms underlying alteration were investigated, including endothelial dysfunction, insulin resistance, oxidative stress, ion channel abnormalities, inflammation, angiogenic imbalance, epigenetic modifications. These findings provide valuable insights for developing early intervention strategies therapeutic approaches mitigating risks both mothers offspring exposure.
Язык: Английский
Процитировано
0
Diabetologia, Год журнала: 2024, Номер 67(12), С. 2726 - 2739
Опубликована: Авг. 24, 2024
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9361 - 9361
Опубликована: Авг. 29, 2024
Gestational diabetes mellitus (GDM) represents a prevalent complication during pregnancy, exerting both short-term and long-term impacts on maternal offspring health. This review offers comprehensive outline of DNA methylation modifications observed in various tissues affected by GDM, emphasizing the intricate interplay between dynamics, gene expression, pathogenesis GDM. Furthermore, it explores influence environmental pollutants, nutritional supplementation, prenatal gut microbiota GDM development through alterations profiles. Additionally, this summarizes recent advancements methylation-based diagnostics predictive models early detection risk assessment for subsequent type 2 diabetes. These insights contribute significantly to our understanding epigenetic mechanisms underlying development, thereby enhancing fetal health outcomes advocating further efforts field.
Язык: Английский
Процитировано
1
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Июль 10, 2024
Abstract One third of women in the United States are affected by obesity during pregnancy. Maternal (MO) is associated with an increased risk neurodevelopmental and metabolic disorders offspring. The placenta, located at maternal-fetal interface, a key organ determining fetal development likely contributes to programming long-term offspring health. We profiled term placental transcriptome humans (pre-pregnancy BMI 35+ [MO condition] or 18.5-25 [lean condition]) using single-nucleus RNA-seq compare expression profiles MO versus lean conditions, reveal potential mechanisms underlying disease risk. recovered 62,864 nuclei high quality from 10 samples each maternal-facing fetal-facing sides placenta. On both several cell types, was upregulation hypoxia response genes. side only, gene measures, Gen3G, independent pregnancy cohort bulk tissue RNA-seq. leveraged Gen3G determine genes that correlated impaired neurodevelopment found these be most highly expressed extravillous trophoblasts (EVTs). EVTs further showed strongest correlation between impairment scores (NDIGSs) score. reanalyzed cultured EVTs, NDIGSs exposure hypoxia. Among accounting for score attenuated 44% association NDIGSs. These data suggest may process MO.
Язык: Английский
Процитировано
0