Long COVID science, research and policy

Nature Medicine, Год журнала: 2024, Номер 30(8), С. 2148 - 2164

Опубликована: Авг. 1, 2024

Long COVID represents the constellation of post-acute and long-term health effects caused by SARS-CoV-2 infection; it is a complex, multisystem disorder that can affect nearly every organ system be severely disabling. The cumulative global incidence long around 400 million individuals, which estimated to have an annual economic impact approximately $1 trillion-equivalent about 1% economy. Several mechanistic pathways are implicated in COVID, including viral persistence, immune dysregulation, mitochondrial dysfunction, complement endothelial inflammation microbiome dysbiosis. devastating impacts on individual lives and, due its complexity prevalence, also has major ramifications for systems economies, even threatening progress toward achieving Sustainable Development Goals. Addressing challenge requires ambitious coordinated-but so far absent-global research policy response strategy. In this interdisciplinary review, we provide synthesis state scientific evidence assess human health, systems, economy metrics, forward-looking roadmap.

Язык: Английский

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Long COVID: a clinical update

The Lancet, Год журнала: 2024, Номер 404(10453), С. 707 - 724

Опубликована: Июль 31, 2024

Язык: Английский

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Mechanisms of long COVID and the path toward therapeutics

Cell, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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Mapping the effectiveness and risks of GLP-1 receptor agonists

Nature Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

Язык: Английский

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Interventions for the management of long covid (post-covid condition): living systematic review

BMJ, Год журнала: 2024, Номер unknown, С. e081318 - e081318

Опубликована: Ноя. 27, 2024

Abstract Objective To compare the effectiveness of interventions for management long covid (post-covid condition). Design Living systematic review. Data sources Medline, Embase, CINAHL, PsycInfo, Allied and Complementary Medicine Database, Cochrane Central Register Controlled Trials from inception to December 2023. Eligibility criteria that randomised adults (≥18 years) with drug or non-drug interventions, placebo sham, usual care. Results 24 trials 3695 patients were eligible. Four (n=708 patients) investigated eight (n=985) physical activity rehabilitation, three (n=314) behavioural, four (n=794) dietary, (n=309) medical devices technologies, one (n=585) a combination exercise mental health rehabilitation. Moderate certainty evidence suggested that, compared care, an online programme cognitive behavioural therapy (CBT) probably reduces fatigue (mean difference −8.4, 95% confidence interval (CI) −13.11 −3.69; Checklist Individual Strength subscale; range 8-56, higher scores indicate greater impairment) improves concentration −5.2, −7.97 −2.43; problems 4-28; impairment). online, supervised, combined rehabilitation leads improvement in overall health, estimated 161 more per 1000 (95% CI 61 292 more) experiencing meaningful recovery, symptoms depression −1.50, −2.41 −0.59; Hospital Anxiety Depression Scale 0-21; impairment), quality life (0.04, 0.00 0.08; Patient-Reported Outcomes Measurement Information System 29+2 Profile; −0.022-1; less intermittent aerobic 3-5 times weekly 4-6 weeks function continuous 3.8, 1.12 6.48; SF-36 component summary score; 0-100; No compelling was found support other including, among others, vortioxetine, leronlimab, probiotics-prebiotics, coenzyme Q10, amygdala insula retraining, L-arginine vitamin C, inspiratory muscle training, transcranial direct current stimulation, hyperbaric oxygen, mobile application providing education on covid. Conclusion suggests CBT improve Systematic review registration Open Science Framework https://osf.io/9h7zm/ . Readers’ note This article is living will be updated reflect emerging evidence. Updates may occur up two years date original publication.

Язык: Английский

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Deterministic optimal control compartmental model for COVID-19 infection

Modeling Earth Systems and Environment, Год журнала: 2025, Номер 11(2)

Опубликована: Янв. 20, 2025

Язык: Английский

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Health outcomes one year after Omicron infection among 12,789 adults: a community-based cross-sectional study

The Lancet Regional Health - Western Pacific, Год журнала: 2025, Номер unknown, С. 101507 - 101507

Опубликована: Март 1, 2025

Characterizing the paradigm and impact of long COVID is crucial for addressing this worldwide health challenge. This study aimed to investigate prevalence one year after primary Omicron infection characterize differences in long-term consequence between participants with persistent those who fully recovered. a community-based cross-sectional conducted from December 2023 March 2024 at China-Japan Friendship Hospital 16 administrative districts Beijing. 12,789 infected 2022 January were recruited through stratified multistage random sampling included final analysis. Of them, 376 229 without matched further physical examinations. The outcome was infection. Secondary outcomes muscle strength, exercise capacity, health-related quality life (HRQoL), mental health, work status, laboratory tests, Among (media [IQR] age, 48.4 [37.3 61.4] years; 7817 females [61.1%]), 995 them (7.8%) experienced within year, 651 (5.1%) having symptoms. Fatigue (598/995 [60.1%]) post-exertional malaise (367/995 [36.9%]) most common Brain fog had lowest resolution proportion as 4.2% year. odds increased reinfections (odds ratios reinfection 2.592 [95% CI: 2.188 3.061]; two or more: 6.171 [3.227 11.557]; all p < 0.001). Participants markedly lower strength (upper-limb: 26.9 ± 12.4 vs. 29.1 14.5 Kg; lower-limb: 40.0 [27.0 62.0] 43.0 [28.0 59.0] s), worse capacity poorer HRQoL, meaningful difference tests results compared COVID. They also exhibited significantly higher proportions abnormal lung function (FEV1 %pred<80%: 13.0% 2.0%; DLco 32.7% 19.9%) imaging abnormalities (23.5% 13.6%). considerable burden progression neurological symptoms following warrant close monitoring. Utilizing professional questionnaires developing reliable diagnostic tools are necessary improving diagnosis treatment supported by Beijing Research Center Respiratory Infectious Diseases (BJRID2024-012), Chinese Academy Medical Sciences Innovation Fund (2022-I2M-CoV19-005/CIFMS 2021-I2M-1-048), National Natural Science Foundation China (82241056/82200114/82200009), New Cornerstone Foundation.

Язык: Английский

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Cell-Autonomous and Non-Cell-Autonomous Antiviral Immunity via siRNA-Directed RNAi in Drosophila melanogaster

Immune discovery., Год журнала: 2025, Номер 1(1), С. 10001 - 10001

Опубликована: Янв. 1, 2025

In Drosophila melanogaster, the siRNA-directed RNAi pathway provides crucial antiviral defenses. Cell-autonomously, Dicer-2 (Dcr-2) recognizes and cleaves viral dsRNA into siRNAs, which are incorporated RNA-induced silencing complex (RISC). Argonaute 2 (Ago2) then targets RNA, preventing replication. Non-cell-autonomously, infected hemocytes secrete exosomes containing spreading signals to other cells. Additionally, tunneling nanotubes can transfer components between neighboring cells, further enhancing systemic immunity. These findings highlight sophisticated strategies in Drosophila, offering insights for broader research.

Язык: Английский

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Hyperthermia and targeting heat shock proteins: innovative approaches for neurodegenerative disorders and Long COVID

Frontiers in Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Фев. 4, 2025

Neurodegenerative diseases (NDs) and Long COVID represent critical growing global health challenges, characterized by complex pathophysiological mechanisms including neuronal deterioration, protein misfolding, persistent neuroinflammation. The emergence of innovative therapeutic approaches, such as whole-body hyperthermia (WBH), offers promising potential to modulate underlying in NDs related conditions like COVID. WBH, particularly fever-range, enhances mitochondrial function, induces heat shock proteins (HSPs), modulates neuroinflammation—benefits that pharmacological treatments often struggle replicate. HSPs HSP70 HSP90 play pivotal roles folding, aggregation prevention, cellular protection, directly targeting pathological processes seen Alzheimer's, Parkinson's, Huntington's disease. Preliminary findings also suggest WBH's alleviate neurological symptoms COVID, where neuroinflammation serotonin dysregulation are prominent. Despite the absence robust clinical trials, implications WBH extend immune modulation restoration disrupted physiological pathways. However, dual nature hyperthermia's effects—balancing pro-inflammatory anti-inflammatory responses—emphasizes need for dose-controlled applications stringent patient monitoring minimize risks vulnerable populations. While shows interest, significant challenges remain. These include individual variability response, limited accessibility advanced technologies, standardized protocols. Future research must focus on targeted biomarker identification, personalized treatment strategies optimize efficacy integration into paradigms could mark a transformative step addressing these conditions.

Язык: Английский

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Rates of infection with other pathogens after a positive COVID-19 test versus a negative test in US veterans (November, 2021, to December, 2023): a retrospective cohort study

The Lancet Infectious Diseases, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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