Impact of Dysbiosis on Intestinal Health in Young Adults with Chronic Inflammatory Diseases DOI
Emanuel Zenon Aviza Joaquín, Daniel Nestor Chiacchiara

Опубликована: Апрель 24, 2025

Introduction: Gut microbiota played an essential role in human health, especially functions such as digestion, vitamin synthesis and immune regulation. When this microbial balance was altered, dysbiosis emerged, a condition associated with chronic inflammatory diseases (CID) ulcerative colitis Crohn's disease. In Argentina, these pathologies significantly affected young adults, influenced by factors industrialized diets the excessive use of antibiotics. This study analyzed relationship between intestinal CID vulnerable population.Development: The investigation revealed that patients presented lower bacterial diversity increase proinflammatory species, adherent-invasive *Escherichia coli*. Environmental diet low fiber rich saturated fats, well early antibiotics, contributed to alterations. addition, found be increased biomarkers greater clinical severity. Genetic influences on predisposition develop were also identified. considered emerging treatments, probiotics, prebiotics fecal transplantation, which offered promising but still preliminary results.Conclusions: It concluded determinant development progression adults. need implement public health policies promote healthy eating habits control antibiotics highlighted, new research therapeutic interventions based microbiota.

Язык: Английский

Artificial intelligence and food flavor: How AI models are shaping the future and revolutionary technologies for flavor food development DOI Creative Commons
Zhiyong Cui, Chong Qi, Tianxing Zhou

и другие.

Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 1, 2025

Abstract The food flavor science, traditionally reliant on experimental methods, is now entering a promising era with the help of artificial intelligence (AI). By integrating existing technologies AI, researchers can explore and develop new substances in digital environment, saving time resources. More more research will use AI big data to enhance product flavor, improve quality, meet consumer needs, drive industry toward smarter sustainable future. In this review, we elaborate mechanisms recognition their potential impact nutritional regulation. With increase accumulation development internet information technology, databases ingredient have made great progress. These provide detailed content, molecules, chemical properties various compounds, providing valuable support for rapid evaluation components construction screening technology. popularization fields, field has also ushered opportunities. This review explores role enhancing analysis through high‐throughput omics technologies. algorithms offer pathway scientifically formulations, thereby customized meals. Furthermore, it discusses safety challenges into industry.

Язык: Английский

Процитировано

7
Cardiometabolic benefits of a non-industrialized-type diet are linked to gut microbiome modulation DOI Creative Commons
Fuyong Li, Anissa M. Armet, Katri Korpela

и другие.

Cell, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Industrialization adversely affects the gut microbiome and predisposes individuals to chronic non-communicable diseases. We tested a restoration strategy comprising diet that recapitulated key characteristics of non-industrialized dietary patterns (restore diet) bacterium rarely found in industrialized microbiomes (Limosilactobacillus reuteri) randomized controlled feeding trial healthy Canadian adults. The restore diet, despite reducing diversity, enhanced persistence L. reuteri strain from rural Papua New Guinea (PB-W1) redressed several features altered by industrialization. also beneficially microbiota-derived plasma metabolites implicated etiology Considerable cardiometabolic benefits were observed independently administration, which could be accurately predicted baseline diet-responsive features. findings suggest intervention targeted toward restoring can improve host-microbiome interactions likely underpin pathologies, guide recommendations development therapeutic nutritional strategies.

Язык: Английский

Процитировано

6
The Multifaceted Role of Endothelial Sirt1 in Vascular Aging: An Update DOI Creative Commons
Roberto Campagna, Laura Mazzanti, Veronica Pompei

и другие.

Cells, Год журнала: 2024, Номер 13(17), С. 1469 - 1469

Опубликована: Сен. 1, 2024

NAD+-dependent deacetylase sirtuin-1 (Sirt1) belongs to the sirtuins family, known be longevity regulators, and exerts a key role in prevention of vascular aging. By aging, expression levels Sirt1 decline with severe impact on function, such as rise endothelial dysfunction, which turn promotes development cardiovascular diseases. In this context, activity preventing senescence is particularly important. Given counteracting senescence, great efforts have been made deepen knowledge about intricate cross-talks interactions other molecules, order set up possible strategies boost prevent or treat The aim review provide proper background regulation function endothelium discuss recent advances regarding therapeutic targeting counteract

Язык: Английский

Процитировано

15
GLP-1 and the Neurobiology of Eating Control: Recent Advances DOI Creative Commons
Lauren A. Jones, Daniel I. Brierley

Endocrinology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Abstract Obesity is now considered a chronic relapsing progressive disease, associated with increased all-cause mortality that scales bodyweight, affecting more than 1 billion people worldwide. Excess body fat strongly excess energy intake, and most successful anti-obesity medications (AOMs) counter this positive balance through the suppression of eating to drive weight loss. Historically, AOMs have been characterised by modest loss side effects which are compliance-limiting, in some cases life-threatening. However, field obesity pharmacotherapy has entered new era based on analogues gut hormone neuropeptide glucagon-like peptide-1 (GLP-1). The latest versions these drugs elicit unprecedented levels clinical trials, starting be substantiated real-world usage. Notably, reduce primarily reducing via activation GLP-1 receptor multiple sites action CNS, although relevant action, neural circuits recruited remain contentious. Here we provide targeted synthesis recent developments neurobiology, highlighting studies advanced our understanding how signalling modulates eating, identify open questions future challenges believe still need addressed aid prevention and/or treatment obesity.

Язык: Английский

Процитировано

2
Inhibitory Effects of Lysophospholipids on Survival and Interleukin-8 Secretion of HT-29, a Human Colon Cancer-Derived Epithelial Cell DOI Open Access

Y Ohtsuki,

E. Nakamura,

Moe Asakami

и другие.

Biological and Pharmaceutical Bulletin, Год журнала: 2025, Номер 48(2), С. 119 - 125

Опубликована: Фев. 13, 2025

Lysophpsphospholipids (LPLs) are lipid mediators involved in various physiological functions. In daily diets, people consume large amounts of lipids, including LPLs. Exogenous dietary LPLs initially affect epithelial cells and, finally, the entire colon and may be linked to onset prevention colonic diseases, inflammatory bowel disease. However, effects exogenous on remain poorly understood. this study, we used HT-29, a human cancer-derived cell, evaluate under normal states. absence lipopolysaccharide (LPS), several decreased interleukin-8 (IL-8) secretion from HT-29 following order potency based reduction ratio at highest concentration: lysophosphatidylglycerol > lysophosphatidylcholine lysophosphatidyletanolamine lysophosphatidylserine. presence LPS, only lysophosphatidylinositol (LPI) IL-8 induced by LPS. Focusing G protein-coupled receptors (GPCRs) that LPI acts on, PSN375963 AS1269574, GPR119 agonists, It is speculated was reduced via signaling non-inflammatory conditions. Although detailed mechanism remains elucidated, findings LPLs, except for LPI, have inhibitory has an inhibitory/anti-inflammatory effect will help elucidate diseases planning treatment methods future.

Язык: Английский

Процитировано

1
The carotenoid torularhodin alleviates NAFLD by promoting Akkermanisa muniniphila-mediated adenosylcobalamin metabolism DOI Creative Commons

Chang Liu,

Xiaojiao Zheng, Jian Ji

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 8, 2025

Torularhodin, a unique carotenoid, confers beneficial effects on nonalcoholic fatty liver disease (NAFLD). However, the precise mechanism underlying its therapeutic remains unknown. Here, we report that torularhodin alleviates NAFLD in male mice by modulating gut microbiota. Additionally, transplanting fecal microbiota from torularhodin-treated to germ-free also improves NAFLD. Mechanistically, specifically enriches abundance of Akkermansia muciniphila, which promoting synthesis adenosylcobalamin. Utilizing human gastrointestinal system and colonic organoid model, further demonstrate adenosylcobalamin protective against through reducing ceramides, well-known damaging compound, this effect is mediated inhibition hypoxia-inducible factor 2α pathway. Notably, construct electrospun microsphere-encapsulated torularhodin, facilitates slow release colon. Together, our findings indicate potential microbial utilization carotenoids, such as for treating

Язык: Английский

Процитировано

1
Gut-lung Axis mediates asthma pathogenesis: Roles of dietary patterns and their impact on the gut microbiota DOI Creative Commons
Yanbo Liu, Ying Zhou, Haoyue Zhang

и другие.

Experimental and Molecular Pathology, Год журнала: 2025, Номер 142, С. 104964 - 104964

Опубликована: Апрель 8, 2025

The gut-lung axis, a vital signaling network linking the gastrointestinal and pulmonary systems, regulates immune responses progression of respiratory diseases. Nutritional components can modulate gut microbiome regulate synthesis critical intestinal microbial metabolites, which are essential for maintaining homeostasis supporting health. Conversely, poor dietary habits exacerbate asthma other conditions through modulation systemic inflammation responses. Dietary interventions, such as Mediterranean diet, reported to restore balance improve health by increasing production anti-inflammatory potentiating responses, preserving epithelial barrier integrity. In contrast, Western patterns, characterized high fat low fiber intake, disrupt diversity, resulting in increased levels pro-inflammatory metabolites that aggravate airway severity. This review aimed elucidate mechanisms underlying regulatory effects microbes their on asthma. Additionally, previous findings related axis have been summarized, providing insights into potential therapeutic strategies management.

Язык: Английский

Процитировано

1
Exploring the association between dietary indices and metabolic dysfunction-associated steatotic liver disease: Mediation analysis and evidence from NHANES DOI Creative Commons
Qiang Wang,

Rude Chen,

Shaohua Chen

и другие.

PLoS ONE, Год журнала: 2025, Номер 20(4), С. e0321251 - e0321251

Опубликована: Апрель 17, 2025

Background The association between dietary indices and metabolic dysfunction-associated steatotic liver disease (MASLD) has shown inconsistent results in previous studies. Additionally, the potential mediating variables linking quality to MASLD have not been adequately explored. Methods We analyzed data from 6,369 participants National Health Nutrition Examination Survey (NHANES) 2007–2018. Three indices—Healthy Eating Index (HEI), Energy-adjusted Dietary Inflammatory (EDII), Composite Antioxidant (CDAI)—were evaluated for their associations with using logistic regression models adjusted a comprehensive range of covariates. Mediation analysis was performed evaluate roles mediators four domains: insulin resistance (homeostatic model assessment resistance, HOMA-IR; score METS-IR), systemic inflammation (systemic inflammatory response index, SIRI; immune-inflammation SII), obesity or visceral fat distribution (a body shape ABSI; roundness BRI), oxidative stress (Gamma-Glutamyltransferase, GGT; Bilirubin; Uric Acid). Results After adjusting all covariates, only HEI showed consistent inverse MASLD, while EDII CDAI no significant associations. identified METS-IR, HOMA-IR, BRI, ABSI as relationship mediation proportion accounting 47.16%, 48.84%, 52.69%, 13.84%, respectively. Conclusion Higher is associated reduced risk MASLD. findings suggest that partially mediate providing insights into mechanisms diet health.

Язык: Английский

Процитировано

1
Associations between omega-3 fatty acid-derived lipid mediators and markers of inflammation in older subjects with low-grade chronic inflammation DOI
Stefania Lamon‐Fava

Prostaglandins & Other Lipid Mediators, Год журнала: 2025, Номер 176, С. 106948 - 106948

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Cross-Sectional Comparative Analysis of Gut Microbiota in Spanish Adolescents with Mediterranean and Western Diets DOI Open Access
Marina Redruello-Requejo,

María del Mar Blaya,

Daniel González-Reguero

и другие.

Nutrients, Год журнала: 2025, Номер 17(3), С. 388 - 388

Опубликована: Янв. 22, 2025

Dietary patterns, such as the Mediterranean diet (MD) and Western (WD), influence gut microbiota composition functionality, which play important roles in energy metabolism nutrient absorption. Objectives: A descriptive cross-sectional study was designed to evaluate of 19 Spanish adolescents investigate association MD ultra-processed food (UPF) intake with microbial diversity community structure. Methods: Functional evaluated using Biolog EcoPlates, taxonomic assessed 16S rRNA sequencing via MinION, phenotypic responses antibiotics were analyzed cenoantibiogram technique under aerobic anaerobic conditions. Results: Adolescents higher adherence exhibited greater functional diversity, per Shannon–Weaver index. In addition, this group showed abundance bacterial genera previously described beneficial, Paraclostridium, Anaerobutyricum, Romboutsia, Butyricicoccus. contrast, reporting UPF intakes had a similar those low MD, characterized by decreased beneficial genera. Regarding antibiotic resistance, significant differences only observed conditions, individuals showing more sensitivity for most tested. Conclusions: These results suggest that promotes healthier balanced environment, potentially improving metabolic functions adolescents. Despite lack α-diversity, comparisons structure between following high (characteristic WD) clear terms β-diversity. findings dietary patterns complex manner, beyond just richness. The outcomes exploratory highlight opportunities future research deepen understanding long-term health implications these well mechanisms regulating composition, communities.

Язык: Английский

Процитировано

0